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OPENSEQ.org
RMLD - dTDP-4-dehydrorhamnose reductase
UniProt: P37760 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12411
Length: 299 (289)
Sequences: 25267
Seq/Len: 87.43
RMLD
Paralog alert: 0.91 [within 20: 0.59] - ratio of genomes with paralogs
Cluster includes: FCL GALE GM4D HLDD QOR2 RMLB1 RMLB2 RMLD YBJS YEEZ YFCH YRAR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
8_K 28_A 3.186 1.00
229_L 283_Q 3.102 1.00
19_A 194_D 2.856 1.00
213_Y 274_N 2.855 1.00
195_C 215_L 2.82 1.00
47_A 94_E 2.714 1.00
281_D 284_V 2.703 1.00
269_E 273_Q 2.7 1.00
2_N 25_N 2.618 1.00
232_E 283_Q 2.491 1.00
79_L 83_T 2.446 1.00
272_Q 278_V 2.372 1.00
211_G 270_K 2.365 1.00
57_I 200_I 2.32 1.00
42_N 45_G 2.27 1.00
73_E 76_F 2.245 1.00
38_G 45_G 2.231 1.00
5_L 17_Q 2.102 1.00
233_E 287_K 2.05 1.00
229_L 232_E 2.037 1.00
29_F 38_G 2.006 1.00
224_Y 228_A 1.986 1.00
23_L 201_R 1.982 1.00
19_A 197_A 1.972 1.00
4_L 55_P 1.925 1.00
102_Y 196_T 1.924 1.00
117_L 120_D 1.924 1.00
222_T 225_D 1.924 1.00
60_N 101_H 1.91 1.00
190_E 288_R 1.906 1.00
149_F 199_A 1.886 1.00
225_D 228_A 1.847 1.00
19_A 23_L 1.823 1.00
155_Y 285_G 1.794 1.00
27_I 55_P 1.775 1.00
218_S 272_Q 1.763 1.00
16_L 59_V 1.761 1.00
194_D 198_H 1.753 1.00
41_S 79_L 1.753 1.00
48_E 52_S 1.742 1.00
6_F 60_N 1.729 1.00
2_N 27_I 1.727 1.00
188_G 288_R 1.726 1.00
229_L 233_E 1.707 1.00
27_I 36_Y 1.695 1.00
16_L 193_A 1.692 1.00
59_V 200_I 1.634 1.00
47_A 91_A 1.631 1.00
19_A 22_P 1.614 1.00
43_P 90_K 1.606 1.00
149_F 196_T 1.58 1.00
86_E 138_A 1.579 1.00
17_Q 28_A 1.565 1.00
151_T 196_T 1.561 1.00
27_I 53_I 1.554 1.00
139_L 146_H 1.552 1.00
122_T 133_L 1.53 1.00
197_A 201_R 1.511 1.00
175_E 247_N 1.504 1.00
86_E 90_K 1.5 1.00
287_K 291_N 1.496 1.00
16_L 61_A 1.489 1.00
108_F 214_H 1.473 1.00
271_F 275_F 1.465 1.00
3_I 24_G 1.449 1.00
168_R 172_E 1.436 1.00
58_I 92_A 1.435 1.00
133_L 137_K 1.432 1.00
12_V 154_V 1.423 1.00
103_S 107_V 1.422 1.00
59_V 196_T 1.42 1.00
98_W 145_K 1.408 1.00
75_E 79_L 1.4 0.99
284_V 287_K 1.393 0.99
83_T 86_E 1.391 0.99
268_T 272_Q 1.368 0.99
151_T 192_L 1.36 0.99
85_V 135_G 1.346 0.99
90_K 93_N 1.334 0.99
20_L 197_A 1.334 0.99
78_Q 134_A 1.316 0.99
118_E 270_K 1.31 0.99
19_A 193_A 1.298 0.99
43_P 47_A 1.29 0.99
188_G 285_G 1.289 0.99
8_K 17_Q 1.289 0.99
48_E 51_R 1.283 0.99
18_R 158_K 1.283 0.99
198_H 202_V 1.282 0.99
60_N 85_V 1.28 0.99
43_P 87_A 1.266 0.99
50_V 58_I 1.261 0.99
92_A 99_V 1.255 0.99
117_L 267_N 1.249 0.99
194_D 277_L 1.247 0.99
211_G 274_N 1.245 0.98
130_E 134_A 1.239 0.98
45_G 48_E 1.238 0.98
195_C 271_F 1.227 0.98
19_A 190_E 1.224 0.98
140_Q 148_I 1.223 0.98
137_K 140_Q 1.219 0.98
194_D 280_P 1.217 0.98
250_P 253_A 1.204 0.98
23_L 197_A 1.202 0.98
189_A 193_A 1.201 0.98
47_A 95_V 1.193 0.98
88_I 99_V 1.19 0.98
2_N 56_D 1.183 0.98
270_K 274_N 1.174 0.98
14_W 158_K 1.171 0.98
11_Q 156_A 1.166 0.97
169_L 174_E 1.166 0.97
183_F 220_T 1.16 0.97
15_E 190_E 1.16 0.97
128_Y 132_K 1.156 0.97
116_W 120_D 1.152 0.97
283_Q 287_K 1.147 0.97
140_Q 146_H 1.145 0.97
51_R 95_V 1.139 0.97
81_N 131_T 1.138 0.97
187_T 192_L 1.136 0.97
175_E 245_K 1.134 0.97
24_G 201_R 1.13 0.97
90_K 94_E 1.129 0.97
102_Y 151_T 1.128 0.97
40_F 84_S 1.128 0.97
98_W 147_L 1.123 0.97
270_K 273_Q 1.119 0.96
213_Y 270_K 1.116 0.96
228_A 231_F 1.114 0.96
91_A 95_V 1.113 0.96
89_A 142_Y 1.107 0.96
221_T 282_W 1.107 0.96
3_I 57_I 1.101 0.96
284_V 288_R 1.097 0.96
113_D 117_L 1.097 0.96
152_S 266_L 1.088 0.96
101_H 135_G 1.086 0.96
136_E 150_R 1.082 0.96
4_L 29_F 1.074 0.95
140_Q 212_L 1.068 0.95
18_R 22_P 1.057 0.95
280_P 284_V 1.047 0.94
47_A 51_R 1.043 0.94
280_P 288_R 1.042 0.94
99_V 139_L 1.039 0.94
44_E 48_E 1.038 0.94
61_A 102_Y 1.037 0.94
185_A 218_S 1.035 0.94
119_T 270_K 1.034 0.94
150_R 212_L 1.025 0.93
198_H 275_F 1.022 0.93
148_I 212_L 1.017 0.93
21_A 26_L 1.014 0.93
80_I 84_S 1.013 0.93
29_F 46_V 1.011 0.93
138_A 141_E 1.01 0.93
113_D 120_D 1.009 0.93
40_F 62_A 1.004 0.93
101_H 139_L 1.002 0.92
233_E 283_Q 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1n2sA111000.121Contact Map0.712
3sc6A60.93651000.143Contact Map0.81
1vl0A30.92981000.162Contact Map0.761
1sb8A10.96321000.164Contact Map0.713
1rkxA40.96661000.173Contact Map0.806
2pzmA20.94311000.174Contact Map0.734
3rufA40.96661000.177Contact Map0.767
2ydyA10.97321000.186Contact Map0.721
1rpnA40.95991000.188Contact Map0.794
3slgA60.96321000.19Contact Map0.805
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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