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OPENSEQ.org
QOR2 - Quinone oxidoreductase 2
UniProt: P39315 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12507
Length: 286 (282)
Sequences: 24075
Seq/Len: 85.37
QOR2
Paralog alert: 0.91 [within 20: 0.51] - ratio of genomes with paralogs
Cluster includes: FCL GALE GM4D HLDD QOR2 RMLB1 RMLB2 RMLD YBJS YEEZ YFCH YRAR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
60_T 93_A 3.088 1.00
7_A 30_A 3.064 1.00
211_K 275_A 3.031 1.00
208_E 275_A 3.028 1.00
18_S 176_A 2.901 1.00
273_T 276_E 2.853 1.00
177_A 194_L 2.755 1.00
264_S 270_P 2.648 1.00
192_Y 266_L 2.632 1.00
55_D 58_A 2.527 1.00
51_A 58_A 2.399 1.00
68_K 182_I 2.371 1.00
261_K 265_K 2.346 1.00
3_A 66_V 2.294 1.00
4_I 16_I 2.294 1.00
190_K 262_T 2.259 1.00
31_I 51_A 2.209 1.00
22_T 183_S 2.066 1.00
98_F 131_V 2.066 1.00
203_T 207_A 2.011 1.00
204_Q 207_A 1.983 1.00
67_E 97_K 1.975 1.00
201_T 204_Q 1.956 1.00
1_M 27_Q 1.923 1.00
212_Q 279_S 1.914 1.00
172_A 280_H 1.878 1.00
18_S 22_T 1.876 1.00
18_S 179_A 1.872 1.00
29_V 47_T 1.864 1.00
208_E 211_K 1.842 1.00
15_V 175_A 1.841 1.00
208_E 212_Q 1.807 1.00
29_V 66_V 1.797 1.00
56_E 89_N 1.772 1.00
176_A 180_R 1.771 1.00
141_S 277_S 1.769 1.00
102_T 178_A 1.744 1.00
135_L 181_V 1.734 1.00
29_V 49_R 1.732 1.00
5_T 71_L 1.713 1.00
60_T 90_A 1.704 1.00
78_G 82_P 1.695 1.00
135_L 178_A 1.693 1.00
71_L 101_Y 1.686 1.00
170_T 280_H 1.682 1.00
85_R 124_M 1.657 1.00
176_A 272_T 1.656 1.00
98_F 133_T 1.644 1.00
15_V 70_L 1.64 1.00
18_S 21_K 1.631 1.00
85_R 89_N 1.625 1.00
22_T 26_S 1.612 1.00
15_V 72_I 1.611 1.00
70_L 182_I 1.6 1.00
69_L 91_A 1.559 1.00
223_S 226_D 1.545 1.00
89_N 92_K 1.527 1.00
27_Q 47_T 1.518 1.00
263_L 267_I 1.51 1.00
125_L 132_Y 1.493 1.00
84_H 121_T 1.487 1.00
56_E 60_T 1.484 1.00
56_E 86_N 1.479 1.00
16_I 30_A 1.465 1.00
276_E 279_S 1.464 1.00
2_I 26_S 1.451 1.00
11_L 140_Y 1.449 1.00
137_N 178_A 1.448 1.00
119_I 123_K 1.445 1.00
108_D 193_E 1.441 1.00
54_G 78_G 1.439 1.00
60_T 94_A 1.414 1.00
61_S 64_Q 1.409 1.00
158_I 220_Q 1.386 0.99
58_A 61_S 1.386 0.99
203_T 221_N 1.383 0.99
82_P 85_R 1.38 0.99
26_S 183_S 1.375 0.99
19_L 179_A 1.368 0.99
122_E 136_R 1.331 0.99
210_T 216_Q 1.331 0.99
197_D 264_S 1.315 0.99
179_A 183_S 1.313 0.99
7_A 16_I 1.308 0.99
123_K 126_A 1.307 0.99
180_R 184_E 1.305 0.99
126_A 134_L 1.302 0.99
70_L 178_A 1.301 0.99
165_K 199_A 1.293 0.99
103_S 107_A 1.289 0.99
18_S 175_A 1.282 0.99
63_L 69_L 1.273 0.99
64_Q 94_A 1.265 0.99
14_Y 172_A 1.263 0.99
131_V 188_E 1.254 0.99
3_A 31_I 1.252 0.99
92_K 128_S 1.247 0.99
89_N 93_A 1.246 0.98
275_A 279_S 1.233 0.98
136_R 191_V 1.231 0.98
163_D 201_T 1.218 0.98
2_I 68_K 1.215 0.98
87_V 99_I 1.213 0.98
71_L 84_H 1.209 0.98
276_E 280_H 1.208 0.98
90_A 94_A 1.208 0.98
22_T 179_A 1.205 0.98
260_S 264_S 1.196 0.98
91_A 99_I 1.187 0.98
200_W 274_L 1.182 0.98
116_D 120_E 1.17 0.97
169_A 174_Y 1.164 0.97
101_Y 121_T 1.144 0.97
17_E 144_Y 1.128 0.97
260_S 271_T 1.125 0.97
18_S 172_A 1.124 0.97
58_A 62_A 1.122 0.97
137_N 174_Y 1.121 0.97
279_S 283_N 1.121 0.97
17_E 21_K 1.12 0.96
56_E 93_A 1.117 0.96
167_A 197_D 1.112 0.96
171_R 175_A 1.108 0.96
163_D 203_T 1.103 0.96
53_Y 73_S 1.1 0.96
170_T 277_S 1.099 0.96
53_Y 83_Q 1.099 0.96
190_K 266_L 1.096 0.96
99_I 125_L 1.095 0.96
34_N 48_V 1.09 0.96
39_Q 42_A 1.089 0.96
97_K 131_V 1.088 0.96
262_T 266_L 1.085 0.96
176_A 269_H 1.084 0.96
57_A 60_T 1.082 0.96
91_A 96_V 1.082 0.96
30_A 46_I 1.075 0.95
126_A 132_Y 1.047 0.94
31_I 58_A 1.046 0.94
23_V 26_S 1.043 0.94
207_A 210_T 1.039 0.94
90_A 93_A 1.038 0.94
10_Q 142_E 1.033 0.94
138_G 258_D 1.032 0.94
20_M 46_I 1.027 0.94
57_A 61_S 1.025 0.93
60_T 64_Q 1.024 0.93
212_Q 275_A 1.023 0.93
198_S 273_T 1.021 0.93
200_W 204_Q 1.02 0.93
212_Q 278_V 1.019 0.93
88_I 99_I 1.017 0.93
29_V 65_G 1.016 0.93
192_Y 262_T 1.015 0.93
103_S 122_E 1.014 0.93
34_N 37_K 1.011 0.93
5_T 73_S 1.004 0.93
102_T 137_N 1.004 0.93
114_L 118_H 1.001 0.92
13_H 144_Y 1 0.92
187_H 192_Y 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2zcuA10.9931000.154Contact Map0.702
2jl1A10.98951000.171Contact Map0.718
3e48A20.97551000.239Contact Map0.704
2x4gA10.96851000.258Contact Map0.689
2wm3A10.9651000.26Contact Map0.695
2gasA20.9581000.268Contact Map0.791
1qydA40.96851000.273Contact Map0.854
1qycA20.9581000.274Contact Map0.824
3slgA60.9581000.274Contact Map0.781
3m2pA60.89511000.277Contact Map0.82
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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