| UniProt: | P45469 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12783 | ||
| Length: | 211 (205) | ||
| Sequences: | 27964 | ||
| Seq/Len: | 136.41 |
| YRAR
Paralog alert: 0.91 [within 20: 0.62] - ratio of genomes with paralogs Cluster includes: FCL GALE GM4D HLDD QOR2 RMLB1 RMLB2 RMLD YBJS YEEZ YFCH YRAR |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 9_A | 32_A | 3.078 | 1.00 | |
| 20_M | 184_R | 2.891 | 1.00 | |
| 56_L | 100_R | 2.707 | 1.00 | |
| 3_Q | 29_A | 2.61 | 1.00 | |
| 85_H | 89_T | 2.519 | 1.00 | |
| 65_I | 190_S | 2.311 | 1.00 | |
| 6_I | 18_L | 2.184 | 1.00 | |
| 20_M | 187_L | 2.063 | 1.00 | |
| 109_V | 186_M | 2.035 | 1.00 | |
| 5_L | 63_I | 2.006 | 1.00 | |
| 79_S | 82_A | 1.996 | 1.00 | |
| 31_A | 63_I | 1.983 | 1.00 | |
| 105_H | 139_P | 1.976 | 1.00 | |
| 33_P | 50_P | 1.965 | 1.00 | |
| 20_M | 24_E | 1.944 | 1.00 | |
| 24_E | 191_M | 1.92 | 1.00 | |
| 3_Q | 31_A | 1.913 | 1.00 | |
| 68_C | 108_V | 1.881 | 1.00 | |
| 17_L | 183_A | 1.86 | 1.00 | |
| 144_A | 189_E | 1.824 | 1.00 | |
| 64_D | 104_Q | 1.805 | 1.00 | |
| 92_V | 96_L | 1.785 | 1.00 | |
| 50_P | 54_D | 1.769 | 1.00 | |
| 56_L | 97_T | 1.74 | 1.00 | |
| 7_T | 68_C | 1.733 | 1.00 | |
| 92_V | 132_A | 1.704 | 1.00 | |
| 17_L | 67_F | 1.668 | 1.00 | |
| 105_H | 142_T | 1.648 | 1.00 | |
| 67_F | 190_S | 1.632 | 1.00 | |
| 133_L | 141_L | 1.63 | 1.00 | |
| 31_A | 46_N | 1.611 | 1.00 | |
| 144_A | 186_M | 1.59 | 1.00 | |
| 31_A | 48_H | 1.584 | 1.00 | |
| 184_R | 188_A | 1.583 | 1.00 | |
| 127_G | 131_E | 1.581 | 1.00 | |
| 146_P | 186_M | 1.548 | 1.00 | |
| 20_M | 23_N | 1.544 | 1.00 | |
| 66_V | 98_G | 1.534 | 1.00 | |
| 187_L | 191_M | 1.533 | 1.00 | |
| 21_L | 187_L | 1.524 | 1.00 | |
| 188_A | 192_R | 1.52 | 1.00 | |
| 204_S | 208_K | 1.516 | 1.00 | |
| 17_L | 69_C | 1.491 | 1.00 | |
| 84_I | 128_E | 1.491 | 1.00 | |
| 134_I | 143_I | 1.483 | 1.00 | |
| 110_S | 114_A | 1.479 | 1.00 | |
| 56_L | 101_L | 1.439 | 1.00 | |
| 13_V | 149_L | 1.436 | 1.00 | |
| 18_L | 32_A | 1.435 | 1.00 | |
| 67_F | 186_M | 1.43 | 1.00 | |
| 4_V | 26_K | 1.416 | 1.00 | |
| 91_V | 129_M | 1.411 | 1.00 | |
| 89_T | 92_V | 1.39 | 0.99 | |
| 96_L | 99_R | 1.378 | 0.99 | |
| 131_E | 134_I | 1.371 | 0.99 | |
| 16_H | 180_R | 1.365 | 0.99 | |
| 108_V | 129_M | 1.364 | 0.99 | |
| 146_P | 182_V | 1.337 | 0.99 | |
| 95_A | 136_Q | 1.331 | 0.99 | |
| 177_I | 182_V | 1.322 | 0.99 | |
| 20_M | 183_A | 1.318 | 0.99 | |
| 59_V | 66_V | 1.316 | 0.99 | |
| 5_L | 33_P | 1.315 | 0.99 | |
| 12_L | 151_G | 1.306 | 0.99 | |
| 29_A | 46_N | 1.306 | 0.99 | |
| 9_A | 18_L | 1.306 | 0.99 | |
| 81_E | 85_H | 1.285 | 0.99 | |
| 24_E | 187_L | 1.285 | 0.99 | |
| 87_D | 125_V | 1.279 | 0.99 | |
| 98_G | 103_A | 1.263 | 0.99 | |
| 4_V | 65_I | 1.261 | 0.99 | |
| 69_C | 109_V | 1.259 | 0.99 | |
| 109_V | 146_P | 1.256 | 0.99 | |
| 134_I | 141_L | 1.256 | 0.99 | |
| 205_E | 208_K | 1.253 | 0.99 | |
| 98_G | 106_M | 1.251 | 0.99 | |
| 68_C | 91_V | 1.25 | 0.99 | |
| 150_L | 178_D | 1.247 | 0.99 | |
| 202_S | 205_E | 1.242 | 0.98 | |
| 26_K | 191_M | 1.24 | 0.98 | |
| 54_D | 57_A | 1.24 | 0.98 | |
| 20_M | 180_R | 1.232 | 0.98 | |
| 7_T | 94_T | 1.217 | 0.98 | |
| 94_T | 106_M | 1.215 | 0.98 | |
| 179_A | 183_A | 1.209 | 0.98 | |
| 124_R | 128_E | 1.203 | 0.98 | |
| 3_Q | 64_D | 1.2 | 0.98 | |
| 36_R | 47_P | 1.193 | 0.98 | |
| 95_A | 106_M | 1.166 | 0.97 | |
| 130_E | 145_R | 1.163 | 0.97 | |
| 4_V | 21_L | 1.148 | 0.97 | |
| 16_H | 179_A | 1.144 | 0.97 | |
| 99_R | 137_N | 1.14 | 0.97 | |
| 178_D | 181_D | 1.137 | 0.97 | |
| 19_R | 23_N | 1.135 | 0.97 | |
| 97_T | 101_L | 1.134 | 0.97 | |
| 96_L | 100_R | 1.129 | 0.97 | |
| 86_A | 90_L | 1.127 | 0.97 | |
| 19_R | 153_R | 1.113 | 0.96 | |
| 122_Y | 126_K | 1.104 | 0.96 | |
| 10_T | 34_T | 1.101 | 0.96 | |
| 149_L | 182_V | 1.099 | 0.96 | |
| 88_Y | 128_E | 1.095 | 0.96 | |
| 12_L | 179_A | 1.092 | 0.96 | |
| 16_H | 19_R | 1.09 | 0.96 | |
| 36_R | 39_G | 1.087 | 0.96 | |
| 89_T | 93_D | 1.086 | 0.96 | |
| 97_T | 100_R | 1.083 | 0.96 | |
| 139_P | 142_T | 1.079 | 0.95 | |
| 132_A | 135_A | 1.077 | 0.95 | |
| 106_M | 133_L | 1.066 | 0.95 | |
| 108_V | 143_I | 1.055 | 0.95 | |
| 107_L | 144_A | 1.038 | 0.94 | |
| 110_S | 130_E | 1.031 | 0.94 | |
| 17_L | 21_L | 1.026 | 0.94 | |
| 66_V | 94_T | 1.021 | 0.93 | |
| 7_T | 70_L | 1.013 | 0.93 | |
| 104_Q | 139_P | 1.012 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2x4gA | 1 | 0.981 | 100 | 0.163 | Contact Map | 0.665 |
| 3m2pA | 6 | 0.9716 | 100 | 0.172 | Contact Map | 0.845 |
| 2pzmA | 2 | 0.9763 | 100 | 0.174 | Contact Map | 0.778 |
| 1sb8A | 1 | 0.981 | 100 | 0.179 | Contact Map | 0.77 |
| 2yy7A | 2 | 0.981 | 100 | 0.191 | Contact Map | 0.846 |
| 3rufA | 4 | 0.981 | 100 | 0.193 | Contact Map | 0.78 |
| 3slgA | 6 | 0.9763 | 100 | 0.195 | Contact Map | 0.823 |
| 2c5aA | 2 | 0.981 | 100 | 0.196 | Contact Map | 0.824 |
| 1orrA | 4 | 0.981 | 100 | 0.196 | Contact Map | 0.771 |
| 2c20A | 6 | 0.981 | 100 | 0.203 | Contact Map | 0.884 |
Sequence Conservation (Image Generated using WebLogo v3)