| UniProt: | P37338 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12386 | ||
| Length: | 220 (208) | ||
| Sequences: | 9960 | ||
| Seq/Len: | 47.88 |
| CSIR
Paralog alert: 0.80 [within 20: 0.20] - ratio of genomes with paralogs Cluster includes: CSIR DGOR EXUR FADR GLCC LLDR MCBR NANR PDHR UXUR YDFH YIEP |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 105_L | 191_L | 4.189 | 1.00 | |
| 90_S | 199_S | 3.323 | 1.00 | |
| 22_Q | 25_E | 3.149 | 1.00 | |
| 194_D | 197_R | 3.147 | 1.00 | |
| 112_S | 184_Q | 2.929 | 1.00 | |
| 15_D | 35_R | 2.627 | 1.00 | |
| 15_D | 20_N | 2.612 | 1.00 | |
| 76_D | 145_H | 2.534 | 1.00 | |
| 83_N | 87_M | 2.33 | 1.00 | |
| 9_Y | 49_Q | 2.302 | 1.00 | |
| 29_M | 40_V | 2.227 | 1.00 | |
| 13_K | 53_E | 2.126 | 1.00 | |
| 8_G | 38_L | 2.085 | 1.00 | |
| 97_G | 100_W | 2.067 | 1.00 | |
| 8_G | 36_Y | 2.046 | 1.00 | |
| 82_A | 207_L | 2.037 | 1.00 | |
| 189_A | 197_R | 1.988 | 1.00 | |
| 94_A | 195_T | 1.903 | 1.00 | |
| 100_W | 143_G | 1.866 | 1.00 | |
| 197_R | 201_L | 1.864 | 1.00 | |
| 103_D | 137_A | 1.815 | 1.00 | |
| 123_M | 126_E | 1.799 | 1.00 | |
| 79_D | 91_L | 1.797 | 1.00 | |
| 101_E | 191_L | 1.779 | 1.00 | |
| 58_V | 64_Y | 1.768 | 1.00 | |
| 57_T | 67_A | 1.7 | 1.00 | |
| 137_A | 140_A | 1.619 | 1.00 | |
| 11_W | 15_D | 1.605 | 1.00 | |
| 135_H | 183_H | 1.597 | 1.00 | |
| 14_N | 18_R | 1.594 | 1.00 | |
| 140_A | 148_L | 1.58 | 1.00 | |
| 188_A | 192_A | 1.573 | 1.00 | |
| 90_S | 196_A | 1.557 | 1.00 | |
| 199_S | 203_R | 1.544 | 1.00 | |
| 80_A | 150_M | 1.516 | 1.00 | |
| 136_T | 152_E | 1.513 | 1.00 | |
| 32_L | 43_L | 1.507 | 1.00 | |
| 86_A | 199_S | 1.506 | 1.00 | |
| 108_A | 187_T | 1.486 | 1.00 | |
| 9_Y | 53_E | 1.466 | 1.00 | |
| 200_E | 204_Q | 1.435 | 1.00 | |
| 192_A | 197_R | 1.416 | 1.00 | |
| 107_K | 130_R | 1.409 | 1.00 | |
| 59_V | 62_K | 1.401 | 0.99 | |
| 86_A | 203_R | 1.383 | 0.99 | |
| 184_Q | 188_A | 1.38 | 0.99 | |
| 182_Q | 205_H | 1.373 | 0.99 | |
| 89_V | 202_M | 1.37 | 0.99 | |
| 87_M | 90_S | 1.352 | 0.99 | |
| 90_S | 195_T | 1.35 | 0.99 | |
| 89_V | 93_I | 1.349 | 0.99 | |
| 138_I | 190_V | 1.328 | 0.99 | |
| 76_D | 146_Y | 1.317 | 0.99 | |
| 31_L | 35_R | 1.315 | 0.99 | |
| 100_W | 141_G | 1.31 | 0.99 | |
| 11_W | 14_N | 1.298 | 0.99 | |
| 197_R | 200_E | 1.295 | 0.99 | |
| 195_T | 199_S | 1.292 | 0.99 | |
| 110_L | 133_A | 1.29 | 0.99 | |
| 149_Q | 153_R | 1.274 | 0.99 | |
| 81_R | 85_E | 1.273 | 0.99 | |
| 96_G | 101_E | 1.27 | 0.99 | |
| 28_R | 31_L | 1.265 | 0.99 | |
| 96_G | 193_R | 1.263 | 0.99 | |
| 139_V | 151_R | 1.26 | 0.99 | |
| 82_A | 203_R | 1.251 | 0.99 | |
| 82_A | 86_A | 1.24 | 0.98 | |
| 142_C | 148_L | 1.237 | 0.98 | |
| 185_T | 201_L | 1.235 | 0.98 | |
| 89_V | 198_A | 1.228 | 0.98 | |
| 182_Q | 208_T | 1.226 | 0.98 | |
| 131_H | 135_H | 1.224 | 0.98 | |
| 106_A | 110_L | 1.215 | 0.98 | |
| 76_D | 144_S | 1.188 | 0.98 | |
| 30_S | 34_S | 1.182 | 0.98 | |
| 133_A | 137_A | 1.177 | 0.98 | |
| 105_L | 109_H | 1.176 | 0.98 | |
| 103_D | 140_A | 1.174 | 0.98 | |
| 96_G | 190_V | 1.171 | 0.98 | |
| 96_G | 141_G | 1.164 | 0.97 | |
| 15_D | 36_Y | 1.163 | 0.97 | |
| 88_L | 139_V | 1.161 | 0.97 | |
| 79_D | 95_R | 1.158 | 0.97 | |
| 51_V | 56_V | 1.149 | 0.97 | |
| 86_A | 90_S | 1.14 | 0.97 | |
| 187_T | 191_L | 1.139 | 0.97 | |
| 59_V | 65_R | 1.134 | 0.97 | |
| 186_L | 201_L | 1.131 | 0.97 | |
| 11_W | 36_Y | 1.128 | 0.97 | |
| 47_L | 56_V | 1.124 | 0.97 | |
| 7_D | 11_W | 1.118 | 0.96 | |
| 186_L | 202_M | 1.114 | 0.96 | |
| 16_I | 66_V | 1.111 | 0.96 | |
| 189_A | 194_D | 1.109 | 0.96 | |
| 79_D | 144_S | 1.106 | 0.96 | |
| 137_A | 141_G | 1.104 | 0.96 | |
| 96_G | 100_W | 1.099 | 0.96 | |
| 51_V | 58_V | 1.099 | 0.96 | |
| 110_L | 130_R | 1.095 | 0.96 | |
| 109_H | 113_K | 1.093 | 0.96 | |
| 105_L | 187_T | 1.079 | 0.95 | |
| 101_E | 187_T | 1.079 | 0.95 | |
| 82_A | 210_I | 1.079 | 0.95 | |
| 185_T | 197_R | 1.079 | 0.95 | |
| 146_Y | 157_L | 1.066 | 0.95 | |
| 98_D | 193_R | 1.05 | 0.94 | |
| 101_E | 193_R | 1.049 | 0.94 | |
| 136_T | 140_A | 1.039 | 0.94 | |
| 45_E | 48_S | 1.033 | 0.94 | |
| 185_T | 204_Q | 1.029 | 0.94 | |
| 56_V | 64_Y | 1.028 | 0.94 | |
| 93_I | 195_T | 1.027 | 0.94 | |
| 129_L | 133_A | 1.027 | 0.94 | |
| 109_H | 112_S | 1.022 | 0.93 | |
| 134_F | 187_T | 1.019 | 0.93 | |
| 183_H | 205_H | 1.017 | 0.93 | |
| 107_K | 137_A | 1.016 | 0.93 | |
| 62_K | 65_R | 1.014 | 0.93 | |
| 196_A | 200_E | 1.007 | 0.93 | |
| 203_R | 207_L | 1.003 | 0.93 | |
| 26_K | 65_R | 1.003 | 0.93 | |
| 13_K | 55_L | 1.002 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3c7jA | 2 | 0.95 | 100 | 0.128 | Contact Map | 0.792 |
| 2hs5A | 1 | 0.9545 | 100 | 0.129 | Contact Map | 0.592 |
| 3sxyA | 2 | 0.9318 | 100 | 0.135 | Contact Map | 0.769 |
| 3ihuA | 2 | 0.9455 | 100 | 0.137 | Contact Map | 0.645 |
| 2di3A | 2 | 0.9636 | 100 | 0.163 | Contact Map | 0.654 |
| 1hw1A | 2 | 0.9364 | 100 | 0.2 | Contact Map | 0.648 |
| 4hamA | 1 | 0.5409 | 99.9 | 0.528 | Contact Map | 0.702 |
| 3ic7A | 2 | 0.5182 | 99.8 | 0.547 | Contact Map | 0.647 |
| 3by6A | 5 | 0.5273 | 99.8 | 0.55 | Contact Map | 0.837 |
| 3neuA | 1 | 0.5091 | 99.8 | 0.567 | Contact Map | 0.662 |
Sequence Conservation (Image Generated using WebLogo v3)