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OPENSEQ.org
EXUR - Exu regulon transcriptional regulator
UniProt: P0ACL2 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12739
Length: 258 (224)
Sequences: 9065
Seq/Len: 40.47
EXUR
Paralog alert: 0.78 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: CSIR DGOR EXUR FADR GLCC LLDR MCBR NANR PDHR UXUR YDFH YIEP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
125_M 203_I 4.462 1.00
110_E 211_K 3.494 1.00
206_D 209_A 3.351 1.00
27_L 30_D 3.29 1.00
132_R 196_D 3.19 1.00
20_R 25_V 2.764 1.00
96_E 157_S 2.705 1.00
20_R 41_E 2.696 1.00
35_E 46_R 2.375 1.00
14_A 55_M 2.333 1.00
103_L 107_N 2.31 1.00
18_K 59_E 2.248 1.00
13_L 44_V 2.234 1.00
13_L 42_K 2.133 1.00
117_T 120_D 2.088 1.00
201_A 209_A 2.077 1.00
102_Q 219_E 2.046 1.00
114_T 207_P 2.038 1.00
120_D 155_Q 1.991 1.00
121_I 203_I 1.913 1.00
123_K 149_Q 1.899 1.00
209_A 213_A 1.877 1.00
64_V 70_I 1.816 1.00
99_Q 111_F 1.794 1.00
110_E 208_H 1.682 1.00
149_Q 152_L 1.67 1.00
63_E 73_V 1.668 1.00
19_E 23_Q 1.663 1.00
200_K 204_R 1.649 1.00
211_K 215_W 1.616 1.00
128_Q 199_L 1.604 1.00
152_L 160_A 1.599 1.00
148_I 164_E 1.591 1.00
38_I 49_V 1.583 1.00
147_H 195_H 1.566 1.00
16_D 20_R 1.563 1.00
106_S 211_K 1.563 1.00
127_I 142_W 1.502 1.00
100_A 162_I 1.47 1.00
204_R 209_A 1.469 1.00
212_L 216_Q 1.451 1.00
196_D 200_K 1.446 1.00
96_E 158_A 1.442 1.00
109_A 113_A 1.437 1.00
194_D 217_H 1.434 1.00
109_A 214_M 1.428 1.00
116_V 121_I 1.406 0.99
110_E 207_P 1.4 0.99
14_A 59_E 1.398 0.99
16_D 19_E 1.394 0.99
109_A 210_A 1.392 0.99
7_R 15_A 1.392 0.99
130_Q 145_Q 1.379 0.99
106_S 215_W 1.367 0.99
99_Q 115_Q 1.366 0.99
116_V 205_K 1.365 0.99
209_A 212_L 1.359 0.99
150_V 202_L 1.35 0.99
120_D 153_A 1.33 0.99
154_T 160_A 1.329 0.99
107_N 110_E 1.323 0.99
65_R 68_S 1.32 0.99
37_F 41_E 1.317 0.99
116_V 202_L 1.312 0.99
126_A 130_Q 1.301 0.99
53_I 62_V 1.298 0.99
198_I 214_M 1.292 0.99
207_P 211_K 1.289 0.99
151_A 163_V 1.276 0.99
96_E 156_N 1.266 0.99
197_Q 213_A 1.264 0.99
102_Q 106_S 1.26 0.99
123_K 152_L 1.255 0.99
116_V 153_A 1.238 0.98
194_D 220_N 1.238 0.98
108_I 151_A 1.228 0.98
36_R 40_D 1.227 0.98
102_Q 215_W 1.225 0.98
125_M 199_L 1.225 0.98
145_Q 149_Q 1.221 0.98
161_A 165_K 1.214 0.98
118_K 205_K 1.211 0.98
65_R 71_H 1.208 0.98
20_R 42_K 1.204 0.98
102_Q 222_K 1.198 0.98
143_D 147_H 1.195 0.98
99_Q 156_N 1.193 0.98
12_Q 16_D 1.181 0.98
16_D 42_K 1.18 0.98
121_I 199_L 1.172 0.98
130_Q 142_W 1.167 0.97
101_R 105_E 1.167 0.97
121_I 205_K 1.165 0.97
21_I 72_V 1.163 0.97
57_E 62_V 1.163 0.97
106_S 110_E 1.158 0.97
146_F 199_L 1.157 0.97
125_M 129_E 1.147 0.97
62_V 70_I 1.146 0.97
149_Q 153_A 1.138 0.97
201_A 206_D 1.128 0.97
198_I 213_A 1.124 0.97
197_Q 216_Q 1.121 0.97
195_H 217_H 1.12 0.96
57_E 64_V 1.118 0.96
208_H 212_L 1.114 0.96
197_Q 209_A 1.114 0.96
199_L 203_I 1.109 0.96
116_V 120_D 1.109 0.96
127_I 149_Q 1.108 0.96
113_A 207_P 1.101 0.96
68_S 71_H 1.095 0.96
132_R 192_C 1.087 0.96
128_Q 196_D 1.063 0.95
51_E 54_I 1.061 0.95
129_E 133_G 1.046 0.94
148_I 152_L 1.046 0.94
18_K 61_Y 1.044 0.94
158_A 169_Q 1.044 0.94
26_Y 72_V 1.038 0.94
129_E 132_R 1.038 0.94
44_V 49_V 1.036 0.94
147_H 217_H 1.035 0.94
95_F 222_K 1.029 0.94
215_W 219_E 1.026 0.94
14_A 18_K 1.024 0.93
124_L 149_Q 1.021 0.93
160_A 164_E 1.02 0.93
200_K 203_I 1.015 0.93
113_A 205_K 1.012 0.93
31_K 71_H 1.01 0.93
113_A 210_A 1.004 0.93
45_S 48_V 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3sxyA20.82171000.32Contact Map0.782
2hs5A10.83331000.326Contact Map0.589
3c7jA20.8451000.329Contact Map0.797
3ihuA20.81011000.33Contact Map0.657
2di3A20.89531000.338Contact Map0.655
1hw1A20.9071000.361Contact Map0.624
4hamA10.488499.90.611Contact Map0.703
3by6A50.476799.90.622Contact Map0.843
3ic7A20.465199.90.622Contact Map0.644
3neuA10.457499.80.638Contact Map0.665
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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