May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
NANR - Transcriptional regulator NanR
UniProt: P0A8W0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12817
Length: 263 (227)
Sequences: 8435
Seq/Len: 37.16
NANR
Paralog alert: 0.78 [within 20: 0.17] - ratio of genomes with paralogs
Cluster includes: CSIR DGOR EXUR FADR GLCC LLDR MCBR NANR PDHR UXUR YDFH YIEP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
152_A 230_R 4.636 1.00
137_R 238_D 3.462 1.00
233_D 236_E 3.364 1.00
50_G 53_E 3.359 1.00
159_S 223_I 3.231 1.00
123_H 186_P 2.736 1.00
43_M 48_E 2.7 1.00
43_M 64_F 2.66 1.00
58_E 69_R 2.508 1.00
37_E 78_A 2.224 1.00
41_E 82_K 2.206 1.00
130_F 134_S 2.203 1.00
36_V 67_V 2.202 1.00
36_V 65_F 2.193 1.00
228_A 236_E 2.145 1.00
144_T 147_Q 2.083 1.00
147_Q 184_G 2.046 1.00
129_L 246_N 2.023 1.00
141_E 234_P 1.99 1.00
236_E 240_A 1.861 1.00
148_I 230_R 1.842 1.00
150_L 178_V 1.83 1.00
87_I 93_A 1.797 1.00
137_R 235_D 1.746 1.00
164_N 167_A 1.742 1.00
126_Q 138_Y 1.736 1.00
227_D 231_R 1.663 1.00
86_Q 96_S 1.658 1.00
155_L 226_V 1.655 1.00
61_L 72_V 1.633 1.00
176_H 222_H 1.621 1.00
178_V 181_E 1.595 1.00
177_R 193_V 1.592 1.00
42_Q 46_R 1.59 1.00
154_A 171_S 1.575 1.00
136_V 140_A 1.553 1.00
30_K 38_E 1.533 1.00
181_E 189_M 1.533 1.00
238_D 242_Q 1.528 1.00
221_Q 244_H 1.492 1.00
239_R 243_S 1.485 1.00
223_I 227_D 1.477 1.00
39_E 43_M 1.466 1.00
133_S 238_D 1.456 1.00
126_Q 142_H 1.436 1.00
157_I 174_D 1.432 1.00
136_V 241_L 1.426 1.00
143_A 148_I 1.426 1.00
143_A 232_H 1.425 1.00
231_R 236_E 1.423 1.00
137_R 234_P 1.413 1.00
37_E 82_K 1.408 1.00
127_L 191_I 1.402 0.99
236_E 239_R 1.393 0.99
179_L 229_I 1.372 0.99
123_H 187_I 1.362 0.99
143_A 229_I 1.36 0.99
88_N 91_E 1.358 0.99
183_P 189_M 1.343 0.99
136_V 237_A 1.331 0.99
39_E 42_Q 1.327 0.99
234_P 238_D 1.321 0.99
76_L 85_V 1.312 0.99
221_Q 247_S 1.308 0.99
225_I 241_L 1.307 0.99
134_S 137_R 1.302 0.99
143_A 182_I 1.299 0.99
135_L 180_A 1.293 0.99
60_E 64_F 1.293 0.99
133_S 242_Q 1.292 0.99
153_K 157_I 1.289 0.99
172_D 176_H 1.289 0.99
128_R 132_E 1.287 0.99
148_I 232_H 1.282 0.99
129_L 133_S 1.257 0.99
147_Q 182_I 1.251 0.99
145_D 232_H 1.243 0.98
123_H 185_N 1.239 0.98
150_L 181_E 1.239 0.98
180_A 192_H 1.236 0.98
225_I 240_A 1.226 0.98
224_A 240_A 1.223 0.98
190_A 194_A 1.221 0.98
43_M 65_F 1.218 0.98
157_I 171_S 1.206 0.98
148_I 226_V 1.202 0.98
129_L 242_Q 1.199 0.98
59_R 63_A 1.196 0.98
152_A 226_V 1.195 0.98
88_N 94_R 1.193 0.98
222_H 244_H 1.182 0.98
152_A 156_E 1.175 0.98
91_E 94_R 1.174 0.98
174_D 178_V 1.16 0.97
175_F 226_V 1.158 0.97
85_V 93_A 1.155 0.97
224_A 243_S 1.144 0.97
39_E 65_F 1.143 0.97
126_Q 185_N 1.136 0.97
80_K 87_I 1.123 0.97
226_V 230_R 1.12 0.96
80_K 85_V 1.119 0.96
151_L 178_V 1.114 0.96
129_L 249_S 1.114 0.96
44_I 95_V 1.114 0.96
224_A 236_E 1.113 0.96
74_E 77_A 1.104 0.96
178_V 182_I 1.104 0.96
143_A 147_Q 1.1 0.96
61_L 76_L 1.091 0.96
35_M 39_E 1.089 0.96
228_A 233_D 1.087 0.96
133_S 137_R 1.085 0.96
235_D 239_R 1.081 0.95
170_R 174_D 1.074 0.95
67_V 72_V 1.07 0.95
176_H 244_H 1.064 0.95
156_E 159_S 1.064 0.95
154_A 178_V 1.051 0.94
156_E 160_Q 1.05 0.94
140_A 234_P 1.046 0.94
159_S 219_Y 1.036 0.94
49_F 95_V 1.035 0.94
140_A 237_A 1.033 0.94
155_L 223_I 1.033 0.94
187_I 198_W 1.029 0.94
140_A 232_H 1.028 0.94
41_E 84_L 1.023 0.93
122_A 249_S 1.02 0.93
150_L 153_K 1.008 0.93
177_R 181_E 1.007 0.93
189_M 193_V 1.007 0.93
37_E 41_E 1.007 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3c7jA20.88971000.318Contact Map0.799
2di3A20.87831000.322Contact Map0.648
3sxyA20.82511000.327Contact Map0.774
2hs5A10.89351000.328Contact Map0.595
3ihuA20.83271000.33Contact Map0.656
1hw1A20.88591000.359Contact Map0.632
4hamA10.505799.90.625Contact Map0.706
3ic7A20.467799.90.625Contact Map0.637
3by6A50.479199.90.631Contact Map0.844
3neuA10.475399.80.652Contact Map0.669
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0648 seconds.