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OPENSEQ.org
DGOR - Galactonate operon transcriptional repressor
UniProt: P31460 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11718
Length: 229 (222)
Sequences: 9937
Seq/Len: 44.76
DGOR
Paralog alert: 0.80 [within 20: 0.20] - ratio of genomes with paralogs
Cluster includes: CSIR DGOR EXUR FADR GLCC LLDR MCBR NANR PDHR UXUR YDFH YIEP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
126_E 203_R 4.426 1.00
111_R 211_E 3.484 1.00
206_D 209_A 3.255 1.00
23_V 26_S 3.234 1.00
133_I 196_K 3.144 1.00
16_Q 21_K 2.733 1.00
16_Q 37_E 2.713 1.00
97_A 160_P 2.65 1.00
104_L 108_A 2.412 1.00
31_E 42_R 2.39 1.00
10_V 51_S 2.323 1.00
9_I 40_T 2.233 1.00
9_I 38_F 2.12 1.00
118_T 121_D 2.083 1.00
14_G 55_K 2.076 1.00
201_A 209_A 2.075 1.00
103_N 219_A 2.066 1.00
124_Q 152_A 1.998 1.00
115_E 207_G 1.98 1.00
209_A 213_A 1.936 1.00
121_D 158_H 1.927 1.00
122_L 203_R 1.923 1.00
100_E 112_W 1.904 1.00
60_M 66_A 1.829 1.00
59_E 69_A 1.778 1.00
15_K 19_H 1.668 1.00
111_R 208_D 1.661 1.00
152_A 155_Q 1.652 1.00
12_T 16_Q 1.624 1.00
200_D 204_H 1.618 1.00
155_Q 163_Q 1.609 1.00
150_H 195_H 1.608 1.00
34_L 45_I 1.598 1.00
101_V 165_L 1.595 1.00
129_L 199_F 1.576 1.00
211_E 215_L 1.565 1.00
107_P 211_E 1.558 1.00
151_E 167_I 1.556 1.00
128_A 145_A 1.555 1.00
138_D 141_A 1.546 1.00
204_H 209_A 1.488 1.00
61_K 64_R 1.471 1.00
110_A 114_A 1.468 1.00
212_Q 216_T 1.466 1.00
196_K 200_D 1.461 1.00
107_P 215_L 1.44 1.00
10_V 55_K 1.439 1.00
111_R 207_G 1.422 1.00
108_A 111_R 1.405 0.99
110_A 214_A 1.401 0.99
194_E 217_M 1.398 0.99
97_A 161_V 1.39 0.99
131_E 148_R 1.384 0.99
117_A 122_L 1.374 0.99
209_A 212_Q 1.36 0.99
207_G 211_E 1.355 0.99
153_V 202_I 1.35 0.99
121_D 156_S 1.343 0.99
127_S 131_E 1.34 0.99
157_V 163_Q 1.325 0.99
33_E 37_E 1.323 0.99
117_A 205_Q 1.317 0.99
110_A 210_A 1.317 0.99
103_N 215_L 1.313 0.99
154_L 166_S 1.308 0.99
12_T 15_K 1.295 0.99
148_R 152_A 1.292 0.99
103_N 107_P 1.287 0.99
194_E 220_S 1.266 0.99
117_A 202_I 1.264 0.99
117_A 156_S 1.264 0.99
61_K 67_F 1.263 0.99
100_E 116_R 1.263 0.99
197_A 213_A 1.261 0.99
97_A 159_N 1.247 0.99
109_I 154_L 1.245 0.98
32_A 36_E 1.23 0.98
126_E 199_F 1.227 0.98
16_Q 38_F 1.225 0.98
164_Q 168_A 1.222 0.98
126_E 130_N 1.216 0.98
124_Q 155_Q 1.208 0.98
146_D 150_H 1.205 0.98
131_E 145_A 1.205 0.98
199_F 203_R 1.204 0.98
53_M 58_I 1.196 0.98
122_L 205_Q 1.187 0.98
12_T 38_F 1.185 0.98
107_P 111_R 1.183 0.98
102_R 106_E 1.179 0.98
49_F 58_I 1.173 0.98
152_A 156_S 1.17 0.97
198_L 214_A 1.164 0.97
53_M 60_M 1.163 0.97
17_I 68_V 1.154 0.97
100_E 159_N 1.143 0.97
197_A 209_A 1.142 0.97
122_L 199_F 1.14 0.97
117_A 121_D 1.125 0.97
128_A 152_A 1.125 0.97
149_Y 199_F 1.123 0.97
201_A 206_D 1.12 0.96
103_N 222_T 1.116 0.96
198_L 213_A 1.115 0.96
114_A 207_G 1.109 0.96
119_S 205_Q 1.098 0.96
47_E 50_R 1.093 0.96
30_A 33_E 1.09 0.96
151_E 155_Q 1.086 0.96
22_Y 68_V 1.085 0.96
130_N 133_I 1.085 0.96
208_D 212_Q 1.084 0.96
195_H 217_M 1.08 0.95
27_P 67_F 1.072 0.95
64_R 67_F 1.061 0.95
133_I 192_L 1.061 0.95
161_V 172_L 1.06 0.95
130_N 134_A 1.057 0.95
129_L 196_K 1.046 0.94
114_A 205_Q 1.041 0.94
58_I 66_A 1.037 0.94
215_L 219_A 1.036 0.94
59_E 67_F 1.036 0.94
197_A 216_T 1.034 0.94
144_E 148_R 1.031 0.94
14_G 57_L 1.031 0.94
8_R 12_T 1.023 0.93
10_V 14_G 1.022 0.93
124_Q 127_S 1.017 0.93
41_S 44_I 1.014 0.93
27_P 65_G 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3c7jA20.90391000.147Contact Map0.795
2di3A20.97381000.149Contact Map0.667
3sxyA20.88651000.158Contact Map0.772
2hs5A10.89961000.162Contact Map0.599
3ihuA20.89521000.169Contact Map0.649
1hw1A20.97821000.181Contact Map0.646
4hamA10.528499.90.522Contact Map0.719
3ic7A20.506699.90.537Contact Map0.673
3by6A50.519799.90.539Contact Map0.85
2ek5A40.55999.80.554Contact Map0.793
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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