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OPENSEQ.org
GLCC - Glc operon transcriptional activator
UniProt: P0ACL5 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12998
Length: 254 (231)
Sequences: 9472
Seq/Len: 41.00
GLCC
Paralog alert: 0.78 [within 20: 0.19] - ratio of genomes with paralogs
Cluster includes: CSIR DGOR EXUR FADR GLCC LLDR MCBR NANR PDHR UXUR YDFH YIEP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
125_T 210_L 4.55 1.00
110_R 218_Q 3.516 1.00
26_K 29_Q 3.304 1.00
213_L 216_V 3.293 1.00
132_L 203_A 3.141 1.00
19_L 40_K 2.744 1.00
96_D 164_Q 2.738 1.00
19_L 24_V 2.691 1.00
34_E 45_R 2.44 1.00
13_A 54_V 2.357 1.00
103_L 107_E 2.348 1.00
12_V 43_F 2.256 1.00
17_E 58_R 2.211 1.00
12_V 41_L 2.199 1.00
208_A 216_V 2.118 1.00
117_T 120_D 2.108 1.00
102_A 226_R 2.052 1.00
142_S 145_E 1.984 1.00
120_D 162_H 1.981 1.00
114_T 214_P 1.967 1.00
216_V 220_A 1.913 1.00
121_F 210_L 1.906 1.00
123_V 156_A 1.872 1.00
63_T 69_S 1.859 1.00
99_D 111_L 1.824 1.00
110_R 215_H 1.695 1.00
18_R 22_D 1.683 1.00
154_H 202_H 1.681 1.00
62_E 72_A 1.664 1.00
156_A 159_Q 1.652 1.00
207_N 211_Q 1.613 1.00
128_Y 206_Y 1.607 1.00
155_L 171_Q 1.603 1.00
218_Q 222_R 1.59 1.00
37_L 48_L 1.563 1.00
201_Q 224_H 1.562 1.00
15_S 19_L 1.559 1.00
159_Q 167_V 1.558 1.00
100_V 169_T 1.553 1.00
106_G 218_Q 1.551 1.00
127_C 149_L 1.548 1.00
219_R 223_D 1.494 1.00
109_A 113_A 1.491 1.00
211_Q 216_V 1.482 1.00
6_R 14_E 1.448 1.00
96_D 165_V 1.438 1.00
64_A 67_R 1.425 1.00
203_A 207_N 1.419 1.00
109_A 221_A 1.414 1.00
130_K 152_A 1.412 1.00
13_A 58_R 1.399 0.99
110_R 214_P 1.395 0.99
157_I 209_V 1.371 0.99
107_E 110_R 1.366 0.99
161_S 167_V 1.365 0.99
106_G 222_R 1.36 0.99
116_G 121_F 1.354 0.99
214_P 218_Q 1.354 0.99
216_V 219_R 1.352 0.99
15_S 18_R 1.351 0.99
109_A 217_A 1.344 0.99
116_G 212_R 1.341 0.99
36_R 40_K 1.337 0.99
120_D 160_A 1.331 0.99
116_G 209_V 1.324 0.99
99_D 115_L 1.291 0.99
102_A 106_G 1.287 0.99
158_C 170_L 1.281 0.99
126_R 130_K 1.279 0.99
201_Q 227_T 1.271 0.99
96_D 163_N 1.261 0.99
116_G 160_A 1.258 0.99
64_A 70_R 1.255 0.99
101_R 105_E 1.251 0.99
168_F 172_S 1.241 0.98
102_A 222_R 1.24 0.98
204_R 220_A 1.24 0.98
35_R 39_E 1.235 0.98
121_F 212_R 1.235 0.98
125_T 206_Y 1.229 0.98
108_S 158_C 1.227 0.98
118_Q 212_R 1.225 0.98
123_V 159_Q 1.221 0.98
15_S 41_L 1.217 0.98
11_V 15_S 1.213 0.98
52_L 61_I 1.213 0.98
19_L 41_L 1.206 0.98
121_F 206_Y 1.204 0.98
205_I 220_A 1.197 0.98
125_T 129_E 1.196 0.98
99_D 163_N 1.183 0.98
152_A 156_A 1.176 0.98
56_R 61_I 1.174 0.98
205_I 221_A 1.172 0.98
106_G 110_R 1.168 0.97
150_D 154_H 1.162 0.97
156_A 160_A 1.161 0.97
130_K 149_L 1.155 0.97
102_A 229_K 1.15 0.97
206_Y 210_L 1.148 0.97
204_R 216_V 1.137 0.97
113_A 214_P 1.135 0.97
116_G 120_D 1.133 0.97
153_F 206_Y 1.131 0.97
61_I 69_S 1.13 0.97
127_C 156_A 1.124 0.97
20_I 71_V 1.124 0.97
129_E 132_L 1.112 0.96
56_R 63_T 1.109 0.96
202_H 224_H 1.103 0.96
208_A 213_L 1.092 0.96
129_E 133_A 1.092 0.96
50_E 53_T 1.083 0.96
155_L 159_Q 1.083 0.96
133_A 137_N 1.077 0.95
25_L 71_V 1.076 0.95
154_H 224_H 1.073 0.95
148_Q 152_A 1.07 0.95
67_R 70_R 1.07 0.95
204_R 223_D 1.069 0.95
30_P 70_R 1.067 0.95
13_A 17_E 1.067 0.95
215_H 219_R 1.059 0.95
165_V 176_L 1.055 0.95
132_L 199_D 1.052 0.95
17_E 60_I 1.044 0.94
33_S 36_R 1.041 0.94
124_I 156_A 1.038 0.94
62_E 70_R 1.028 0.94
222_R 226_R 1.024 0.93
43_F 48_L 1.022 0.93
113_A 212_R 1.018 0.93
128_Y 203_A 1.011 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2di3A20.92521000.264Contact Map0.659
3c7jA20.85831000.27Contact Map0.797
3ihuA20.83461000.274Contact Map0.649
3sxyA20.83461000.277Contact Map0.78
2hs5A10.85831000.285Contact Map0.594
1hw1A20.89371000.3Contact Map0.639
4hamA10.488299.90.583Contact Map0.708
3ic7A20.468599.90.598Contact Map0.654
3by6A50.476499.90.599Contact Map0.848
3neuA10.468599.80.618Contact Map0.67
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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