| UniProt: | P32144 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11849 | ||
| Length: | 261 (251) | ||
| Sequences: | 3479 | ||
| Seq/Len: | 13.86 |
| YIHW
Paralog alert: 0.83 [within 20: 0.11] - ratio of genomes with paralogs Cluster includes: AGAR DEOR FUCR GATR GLPR SGCR SRLR ULAR YCIT YDJF YGBI YIHW |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 111_V | 210_V | 3.582 | 1.00 | |
| 98_S | 172_Y | 3.255 | 1.00 | |
| 89_A | 92_D | 3.071 | 1.00 | |
| 173_L | 204_A | 2.757 | 1.00 | |
| 103_T | 197_V | 2.739 | 1.00 | |
| 141_E | 148_T | 2.573 | 1.00 | |
| 18_L | 33_L | 2.195 | 1.00 | |
| 172_Y | 208_L | 2.183 | 1.00 | |
| 113_R | 133_I | 2.142 | 1.00 | |
| 201_M | 225_G | 2.062 | 1.00 | |
| 208_L | 232_A | 1.991 | 1.00 | |
| 101_F | 170_A | 1.988 | 1.00 | |
| 223_E | 226_N | 1.931 | 1.00 | |
| 172_Y | 206_N | 1.908 | 1.00 | |
| 90_V | 210_V | 1.879 | 1.00 | |
| 90_V | 174_V | 1.875 | 1.00 | |
| 18_L | 22_R | 1.867 | 1.00 | |
| 232_A | 255_I | 1.866 | 1.00 | |
| 170_A | 200_M | 1.865 | 1.00 | |
| 124_I | 170_A | 1.851 | 1.00 | |
| 101_F | 200_M | 1.805 | 1.00 | |
| 201_M | 207_I | 1.797 | 1.00 | |
| 94_I | 115_L | 1.791 | 1.00 | |
| 213_H | 236_D | 1.788 | 1.00 | |
| 30_L | 41_V | 1.781 | 1.00 | |
| 244_K | 248_Q | 1.767 | 1.00 | |
| 88_E | 114_A | 1.757 | 1.00 | |
| 14_Q | 17_M | 1.743 | 1.00 | |
| 95_P | 98_S | 1.742 | 1.00 | |
| 102_I | 108_V | 1.734 | 1.00 | |
| 206_N | 232_A | 1.731 | 1.00 | |
| 123_I | 140_F | 1.728 | 1.00 | |
| 111_V | 174_V | 1.722 | 1.00 | |
| 84_K | 110_H | 1.71 | 1.00 | |
| 98_S | 171_D | 1.707 | 1.00 | |
| 239_P | 244_K | 1.7 | 1.00 | |
| 145_P | 161_A | 1.679 | 1.00 | |
| 96_D | 118_H | 1.666 | 1.00 | |
| 226_N | 229_Q | 1.662 | 1.00 | |
| 163_S | 166_A | 1.657 | 1.00 | |
| 91_A | 114_A | 1.634 | 1.00 | |
| 79_Q | 214_T | 1.633 | 1.00 | |
| 87_A | 114_A | 1.617 | 1.00 | |
| 36_V | 41_V | 1.606 | 1.00 | |
| 96_D | 119_N | 1.605 | 1.00 | |
| 171_D | 205_R | 1.594 | 1.00 | |
| 104_I | 155_G | 1.59 | 1.00 | |
| 110_H | 113_R | 1.589 | 1.00 | |
| 166_A | 199_T | 1.578 | 1.00 | |
| 144_V | 156_I | 1.568 | 1.00 | |
| 79_Q | 82_E | 1.566 | 1.00 | |
| 186_L | 209_L | 1.545 | 1.00 | |
| 131_A | 144_V | 1.535 | 1.00 | |
| 16_L | 53_L | 1.512 | 1.00 | |
| 16_L | 19_I | 1.5 | 1.00 | |
| 45_I | 61_A | 1.5 | 1.00 | |
| 149_L | 156_I | 1.483 | 1.00 | |
| 12_H | 51_Q | 1.483 | 1.00 | |
| 14_Q | 18_L | 1.478 | 1.00 | |
| 163_S | 167_D | 1.46 | 1.00 | |
| 89_A | 255_I | 1.457 | 1.00 | |
| 145_P | 164_F | 1.431 | 1.00 | |
| 123_I | 134_L | 1.421 | 1.00 | |
| 162_A | 195_N | 1.419 | 1.00 | |
| 97_G | 120_H | 1.399 | 0.99 | |
| 24_Y | 62_G | 1.397 | 0.99 | |
| 22_R | 29_E | 1.387 | 0.99 | |
| 209_L | 230_V | 1.387 | 0.99 | |
| 174_V | 208_L | 1.378 | 0.99 | |
| 207_I | 230_V | 1.374 | 0.99 | |
| 93_Y | 234_F | 1.372 | 0.99 | |
| 39_Q | 43_R | 1.37 | 0.99 | |
| 91_A | 111_V | 1.36 | 0.99 | |
| 216_Y | 233_L | 1.357 | 0.99 | |
| 93_Y | 208_L | 1.353 | 0.99 | |
| 13_D | 17_M | 1.348 | 0.99 | |
| 199_T | 203_H | 1.348 | 0.99 | |
| 166_A | 202_A | 1.338 | 0.99 | |
| 199_T | 202_A | 1.338 | 0.99 | |
| 145_P | 156_I | 1.337 | 0.99 | |
| 245_S | 249_D | 1.31 | 0.99 | |
| 18_L | 25_M | 1.307 | 0.99 | |
| 186_L | 230_V | 1.26 | 0.99 | |
| 122_R | 143_M | 1.252 | 0.99 | |
| 240_P | 243_L | 1.247 | 0.99 | |
| 15_L | 30_L | 1.246 | 0.98 | |
| 216_Y | 239_P | 1.244 | 0.98 | |
| 84_K | 114_A | 1.242 | 0.98 | |
| 87_A | 91_A | 1.239 | 0.98 | |
| 206_N | 231_T | 1.236 | 0.98 | |
| 161_A | 196_V | 1.219 | 0.98 | |
| 14_Q | 34_L | 1.219 | 0.98 | |
| 148_T | 192_N | 1.21 | 0.98 | |
| 19_I | 63_R | 1.201 | 0.98 | |
| 91_A | 94_I | 1.2 | 0.98 | |
| 179_A | 187_M | 1.193 | 0.98 | |
| 177_V | 224_I | 1.189 | 0.98 | |
| 19_I | 54_I | 1.187 | 0.98 | |
| 27_I | 45_I | 1.176 | 0.98 | |
| 83_K | 106_T | 1.173 | 0.98 | |
| 180_I | 216_Y | 1.166 | 0.97 | |
| 105_G | 108_V | 1.165 | 0.97 | |
| 26_N | 29_E | 1.158 | 0.97 | |
| 72_F | 106_T | 1.156 | 0.97 | |
| 54_I | 61_A | 1.151 | 0.97 | |
| 177_V | 209_L | 1.149 | 0.97 | |
| 25_M | 30_L | 1.141 | 0.97 | |
| 82_E | 236_D | 1.137 | 0.97 | |
| 177_V | 211_A | 1.136 | 0.97 | |
| 80_T | 110_H | 1.122 | 0.97 | |
| 28_D | 38_T | 1.121 | 0.97 | |
| 112_A | 134_L | 1.116 | 0.96 | |
| 14_Q | 33_L | 1.114 | 0.96 | |
| 108_V | 111_V | 1.112 | 0.96 | |
| 90_V | 234_F | 1.104 | 0.96 | |
| 225_G | 229_Q | 1.102 | 0.96 | |
| 180_I | 211_A | 1.095 | 0.96 | |
| 18_L | 21_E | 1.09 | 0.96 | |
| 57_H | 60_G | 1.085 | 0.96 | |
| 122_R | 141_E | 1.079 | 0.95 | |
| 208_L | 234_F | 1.061 | 0.95 | |
| 198_K | 202_A | 1.055 | 0.95 | |
| 93_Y | 255_I | 1.053 | 0.95 | |
| 107_T | 212_D | 1.047 | 0.94 | |
| 112_A | 133_I | 1.045 | 0.94 | |
| 82_E | 213_H | 1.041 | 0.94 | |
| 90_V | 111_V | 1.038 | 0.94 | |
| 17_M | 21_E | 1.038 | 0.94 | |
| 245_S | 248_Q | 1.035 | 0.94 | |
| 83_K | 215_K | 1.031 | 0.94 | |
| 150_R | 193_E | 1.026 | 0.94 | |
| 12_H | 47_K | 1.011 | 0.93 | |
| 86_I | 107_T | 1 | 0.92 | |
| 145_P | 165_V | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1stzA | 3 | 0.9425 | 100 | 0.52 | Contact Map | 0.273 |
| 3rrlB | 2 | 0.6628 | 100 | 0.53 | Contact Map | 0.568 |
| 2w48A | 4 | 0.908 | 100 | 0.585 | Contact Map | 0.599 |
| 4io1A | 2 | 0.6513 | 100 | 0.616 | Contact Map | 0.683 |
| 3l7oA | 2 | 0.5977 | 100 | 0.618 | Contact Map | 0.74 |
| 4gmkA | 2 | 0.6092 | 100 | 0.619 | Contact Map | 0.745 |
| 1o8bA | 2 | 0.6054 | 100 | 0.627 | Contact Map | 0.603 |
| 1lk5A | 4 | 0.6015 | 100 | 0.631 | Contact Map | 0.759 |
| 1m0sA | 2 | 0.6054 | 100 | 0.632 | Contact Map | 0.728 |
| 1uj6A | 1 | 0.6092 | 100 | 0.633 | Contact Map | 0.669 |
Sequence Conservation (Image Generated using WebLogo v3)