| UniProt: | P15082 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10974 | ||
| Length: | 257 (250) | ||
| Sequences: | 3474 | ||
| Seq/Len: | 13.90 |
| SRLR
Paralog alert: 0.83 [within 20: 0.11] - ratio of genomes with paralogs Cluster includes: AGAR DEOR FUCR GATR GLPR SGCR SRLR ULAR YCIT YDJF YGBI YIHW |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 106_M | 205_M | 3.564 | 1.00 | |
| 93_D | 168_K | 3.245 | 1.00 | |
| 84_A | 87_S | 3.058 | 1.00 | |
| 169_L | 199_A | 2.763 | 1.00 | |
| 98_D | 192_S | 2.744 | 1.00 | |
| 136_Q | 144_T | 2.563 | 1.00 | |
| 13_Y | 28_Y | 2.206 | 1.00 | |
| 168_K | 203_I | 2.191 | 1.00 | |
| 108_P | 128_A | 2.117 | 1.00 | |
| 196_C | 220_C | 2.089 | 1.00 | |
| 96_I | 166_F | 1.998 | 1.00 | |
| 203_I | 227_K | 1.988 | 1.00 | |
| 168_K | 201_E | 1.93 | 1.00 | |
| 85_A | 205_M | 1.913 | 1.00 | |
| 218_V | 221_S | 1.893 | 1.00 | |
| 85_A | 170_F | 1.879 | 1.00 | |
| 227_K | 250_I | 1.87 | 1.00 | |
| 234_I | 239_R | 1.864 | 1.00 | |
| 119_M | 166_F | 1.852 | 1.00 | |
| 13_Y | 17_Q | 1.839 | 1.00 | |
| 166_F | 195_M | 1.833 | 1.00 | |
| 96_I | 195_M | 1.825 | 1.00 | |
| 196_C | 202_V | 1.786 | 1.00 | |
| 208_S | 231_D | 1.784 | 1.00 | |
| 89_I | 110_L | 1.784 | 1.00 | |
| 25_L | 36_I | 1.78 | 1.00 | |
| 201_E | 227_K | 1.773 | 1.00 | |
| 106_M | 170_F | 1.756 | 1.00 | |
| 90_H | 93_D | 1.754 | 1.00 | |
| 91_D | 113_F | 1.735 | 1.00 | |
| 79_E | 105_Q | 1.735 | 1.00 | |
| 97_L | 103_V | 1.732 | 1.00 | |
| 83_E | 109_L | 1.73 | 1.00 | |
| 9_A | 12_E | 1.73 | 1.00 | |
| 221_S | 224_S | 1.715 | 1.00 | |
| 239_R | 243_E | 1.713 | 1.00 | |
| 140_M | 157_A | 1.699 | 1.00 | |
| 118_V | 135_E | 1.68 | 1.00 | |
| 93_D | 167_D | 1.68 | 1.00 | |
| 86_V | 109_L | 1.656 | 1.00 | |
| 74_N | 209_S | 1.653 | 1.00 | |
| 91_D | 114_N | 1.65 | 1.00 | |
| 159_N | 162_E | 1.649 | 1.00 | |
| 31_T | 36_I | 1.645 | 1.00 | |
| 167_D | 200_R | 1.62 | 1.00 | |
| 82_A | 109_L | 1.62 | 1.00 | |
| 162_E | 194_A | 1.599 | 1.00 | |
| 105_Q | 108_P | 1.587 | 1.00 | |
| 74_N | 77_K | 1.584 | 1.00 | |
| 99_A | 151_S | 1.574 | 1.00 | |
| 126_V | 139_L | 1.559 | 1.00 | |
| 139_L | 152_F | 1.552 | 1.00 | |
| 182_V | 204_L | 1.538 | 1.00 | |
| 40_L | 56_V | 1.519 | 1.00 | |
| 11_L | 48_T | 1.507 | 1.00 | |
| 11_L | 14_L | 1.499 | 1.00 | |
| 7_Q | 46_A | 1.492 | 1.00 | |
| 9_A | 13_Y | 1.482 | 1.00 | |
| 140_M | 160_A | 1.474 | 1.00 | |
| 145_F | 152_F | 1.466 | 1.00 | |
| 118_V | 129_L | 1.466 | 1.00 | |
| 84_A | 250_I | 1.445 | 1.00 | |
| 159_N | 163_H | 1.443 | 1.00 | |
| 170_F | 203_I | 1.424 | 1.00 | |
| 19_K | 57_V | 1.415 | 1.00 | |
| 34_T | 38_K | 1.395 | 0.99 | |
| 88_F | 203_I | 1.391 | 0.99 | |
| 17_Q | 24_E | 1.374 | 0.99 | |
| 92_G | 115_N | 1.371 | 0.99 | |
| 202_V | 225_V | 1.355 | 0.99 | |
| 204_L | 225_V | 1.354 | 0.99 | |
| 140_M | 152_F | 1.347 | 0.99 | |
| 8_A | 12_E | 1.338 | 0.99 | |
| 194_A | 198_A | 1.338 | 0.99 | |
| 13_Y | 20_C | 1.337 | 0.99 | |
| 86_V | 106_M | 1.333 | 0.99 | |
| 88_F | 229_I | 1.324 | 0.99 | |
| 162_E | 197_N | 1.312 | 0.99 | |
| 211_F | 228_L | 1.306 | 0.99 | |
| 158_E | 190_T | 1.303 | 0.99 | |
| 194_A | 197_N | 1.298 | 0.99 | |
| 240_Q | 244_E | 1.293 | 0.99 | |
| 235_D | 238_F | 1.286 | 0.99 | |
| 117_T | 138_I | 1.259 | 0.99 | |
| 10_I | 25_L | 1.253 | 0.99 | |
| 82_A | 86_V | 1.25 | 0.99 | |
| 182_V | 225_V | 1.247 | 0.99 | |
| 9_A | 29_F | 1.242 | 0.98 | |
| 67_I | 101_S | 1.237 | 0.98 | |
| 211_F | 234_I | 1.233 | 0.98 | |
| 157_A | 191_V | 1.219 | 0.98 | |
| 201_E | 226_D | 1.215 | 0.98 | |
| 79_E | 109_L | 1.212 | 0.98 | |
| 176_I | 211_F | 1.205 | 0.98 | |
| 86_V | 89_I | 1.199 | 0.98 | |
| 78_K | 101_S | 1.178 | 0.98 | |
| 20_C | 25_L | 1.167 | 0.97 | |
| 173_T | 219_V | 1.167 | 0.97 | |
| 144_T | 187_E | 1.166 | 0.97 | |
| 175_G | 183_T | 1.165 | 0.97 | |
| 49_V | 56_V | 1.165 | 0.97 | |
| 22_V | 40_L | 1.162 | 0.97 | |
| 173_T | 204_L | 1.161 | 0.97 | |
| 100_G | 103_V | 1.16 | 0.97 | |
| 173_T | 206_A | 1.157 | 0.97 | |
| 75_T | 105_Q | 1.144 | 0.97 | |
| 21_S | 24_E | 1.141 | 0.97 | |
| 52_T | 55_G | 1.132 | 0.97 | |
| 14_L | 49_V | 1.13 | 0.97 | |
| 176_I | 206_A | 1.119 | 0.96 | |
| 107_V | 129_L | 1.113 | 0.96 | |
| 77_K | 231_D | 1.11 | 0.96 | |
| 85_A | 229_I | 1.108 | 0.96 | |
| 103_V | 106_M | 1.104 | 0.96 | |
| 220_C | 224_S | 1.096 | 0.96 | |
| 88_F | 250_I | 1.094 | 0.96 | |
| 23_E | 33_G | 1.091 | 0.96 | |
| 9_A | 28_Y | 1.088 | 0.96 | |
| 117_T | 136_Q | 1.074 | 0.95 | |
| 13_Y | 16_K | 1.07 | 0.95 | |
| 102_T | 207_D | 1.055 | 0.95 | |
| 12_E | 16_K | 1.041 | 0.94 | |
| 85_A | 106_M | 1.038 | 0.94 | |
| 107_V | 128_A | 1.033 | 0.94 | |
| 203_I | 229_I | 1.026 | 0.94 | |
| 197_N | 224_S | 1.025 | 0.93 | |
| 7_Q | 42_I | 1.023 | 0.93 | |
| 96_I | 198_A | 1.02 | 0.93 | |
| 78_K | 210_K | 1.019 | 0.93 | |
| 193_K | 197_N | 1.017 | 0.93 | |
| 77_K | 208_S | 1.016 | 0.93 | |
| 161_F | 194_A | 1.015 | 0.93 | |
| 240_Q | 243_E | 1.01 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1stzA | 3 | 0.9377 | 100 | 0.511 | Contact Map | 0.278 |
| 3rrlB | 2 | 0.6732 | 100 | 0.52 | Contact Map | 0.576 |
| 2w48A | 4 | 0.9183 | 100 | 0.56 | Contact Map | 0.6 |
| 4io1A | 2 | 0.642 | 100 | 0.603 | Contact Map | 0.698 |
| 4gmkA | 2 | 0.6226 | 100 | 0.608 | Contact Map | 0.738 |
| 3l7oA | 2 | 0.6109 | 100 | 0.609 | Contact Map | 0.737 |
| 2o0mA | 1 | 0.9377 | 100 | 0.611 | Contact Map | 0.531 |
| 1o8bA | 2 | 0.6187 | 100 | 0.616 | Contact Map | 0.596 |
| 1m0sA | 2 | 0.6148 | 100 | 0.619 | Contact Map | 0.717 |
| 1lk5A | 4 | 0.6187 | 100 | 0.622 | Contact Map | 0.755 |
Sequence Conservation (Image Generated using WebLogo v3)