| UniProt: | P77509 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13466 | ||
| Length: | 503 (489) | ||
| Sequences: | 13957 | ||
| Seq/Len: | 28.54 |
| YPHE
Paralog alert: 0.93 [within 20: 0.28] - ratio of genomes with paralogs Cluster includes: ALSA ARAG GSIA LSRA MGLA MODF RBSA UUP XYLG YBHF YBIT YEJF YHES YJJK YPHE YTFR |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 37_E | 218_C | 4.501 | 1.00 | |
| 271_A | 280_D | 4.364 | 1.00 | |
| 15_A | 28_N | 4.354 | 1.00 | |
| 268_E | 284_T | 4.156 | 1.00 | |
| 27_D | 226_Q | 3.977 | 1.00 | |
| 270_R | 318_E | 3.923 | 1.00 | |
| 289_E | 473_R | 3.747 | 1.00 | |
| 14_V | 66_D | 3.625 | 1.00 | |
| 305_L | 460_I | 3.535 | 1.00 | |
| 269_V | 272_L | 3.436 | 1.00 | |
| 39_R | 220_T | 3.348 | 1.00 | |
| 66_D | 73_R | 3.344 | 1.00 | |
| 12_K | 32_T | 3.234 | 1.00 | |
| 13_V | 16_G | 3.2 | 1.00 | |
| 268_E | 320_V | 3.185 | 1.00 | |
| 318_E | 325_K | 2.963 | 1.00 | |
| 24_V | 27_D | 2.945 | 1.00 | |
| 306_K | 312_E | 2.884 | 1.00 | |
| 279_E | 481_T | 2.783 | 1.00 | |
| 291_L | 475_L | 2.644 | 1.00 | |
| 12_K | 68_W | 2.629 | 1.00 | |
| 40_A | 216_A | 2.595 | 1.00 | |
| 292_G | 471_C | 2.575 | 1.00 | |
| 129_D | 132_R | 2.549 | 1.00 | |
| 269_V | 283_F | 2.546 | 1.00 | |
| 338_G | 424_Q | 2.503 | 1.00 | |
| 70_G | 169_R | 2.496 | 1.00 | |
| 388_M | 398_S | 2.48 | 1.00 | |
| 322_N | 424_Q | 2.479 | 1.00 | |
| 122_D | 125_Q | 2.468 | 1.00 | |
| 232_M | 235_N | 2.445 | 1.00 | |
| 17_N | 28_N | 2.408 | 1.00 | |
| 193_K | 214_R | 2.357 | 1.00 | |
| 53_I | 205_V | 2.354 | 1.00 | |
| 271_A | 282_S | 2.342 | 1.00 | |
| 127_A | 144_E | 2.305 | 1.00 | |
| 270_R | 320_V | 2.3 | 1.00 | |
| 136_A | 198_L | 2.259 | 1.00 | |
| 15_A | 30_N | 2.246 | 1.00 | |
| 145_Q | 149_T | 2.225 | 1.00 | |
| 265_A | 268_E | 2.214 | 1.00 | |
| 19_R | 24_V | 2.201 | 1.00 | |
| 461_S | 467_L | 2.19 | 1.00 | |
| 287_R | 424_Q | 2.123 | 1.00 | |
| 89_G | 169_R | 2.083 | 1.00 | |
| 125_Q | 129_D | 2.075 | 1.00 | |
| 307_A | 314_Y | 2.068 | 1.00 | |
| 354_W | 403_G | 2.025 | 1.00 | |
| 305_L | 427_L | 2.022 | 1.00 | |
| 20_Y | 60_E | 2.018 | 1.00 | |
| 273_R | 280_D | 1.997 | 1.00 | |
| 449_E | 453_E | 1.979 | 1.00 | |
| 304_L | 477_L | 1.975 | 1.00 | |
| 17_N | 24_V | 1.95 | 1.00 | |
| 129_D | 167_E | 1.936 | 1.00 | |
| 13_V | 31_F | 1.922 | 1.00 | |
| 273_R | 316_Q | 1.888 | 1.00 | |
| 34_N | 37_E | 1.847 | 1.00 | |
| 264_Q | 287_R | 1.841 | 1.00 | |
| 79_A | 88_L | 1.837 | 1.00 | |
| 104_T | 107_E | 1.831 | 1.00 | |
| 131_Q | 135_Q | 1.819 | 1.00 | |
| 91_R | 163_V | 1.805 | 1.00 | |
| 286_R | 289_E | 1.792 | 1.00 | |
| 13_V | 56_L | 1.786 | 1.00 | |
| 216_A | 233_L | 1.779 | 1.00 | |
| 220_T | 227_V | 1.764 | 1.00 | |
| 459_F | 470_V | 1.759 | 1.00 | |
| 14_V | 68_W | 1.716 | 1.00 | |
| 285_L | 291_L | 1.715 | 1.00 | |
| 142_S | 145_Q | 1.702 | 1.00 | |
| 283_F | 475_L | 1.701 | 1.00 | |
| 270_R | 282_S | 1.7 | 1.00 | |
| 81_L | 84_R | 1.698 | 1.00 | |
| 128_Q | 132_R | 1.69 | 1.00 | |
| 386_E | 390_R | 1.681 | 1.00 | |
| 35_K | 169_R | 1.677 | 1.00 | |
| 387_V | 420_Y | 1.676 | 1.00 | |
| 309_V | 427_L | 1.663 | 1.00 | |
| 292_G | 467_L | 1.658 | 1.00 | |
| 192_V | 202_V | 1.653 | 1.00 | |
| 17_N | 64_S | 1.652 | 1.00 | |
| 475_L | 485_E | 1.65 | 1.00 | |
| 102_G | 148_S | 1.647 | 1.00 | |
| 33_L | 170_V | 1.629 | 1.00 | |
| 109_L | 165_K | 1.622 | 1.00 | |
| 93_V | 173_L | 1.609 | 1.00 | |
| 424_Q | 455_K | 1.596 | 1.00 | |
| 285_L | 456_S | 1.594 | 1.00 | |
| 240_H | 243_S | 1.589 | 1.00 | |
| 74_L | 79_A | 1.563 | 1.00 | |
| 38_V | 192_V | 1.56 | 1.00 | |
| 265_A | 284_T | 1.557 | 1.00 | |
| 484_Q | 498_A | 1.544 | 1.00 | |
| 146_L | 149_T | 1.543 | 1.00 | |
| 405_L | 413_V | 1.539 | 1.00 | |
| 229_G | 244_L | 1.535 | 1.00 | |
| 387_V | 416_G | 1.528 | 1.00 | |
| 388_M | 395_A | 1.528 | 1.00 | |
| 390_R | 449_E | 1.525 | 1.00 | |
| 269_V | 308_I | 1.519 | 1.00 | |
| 231_V | 236_T | 1.514 | 1.00 | |
| 14_V | 30_N | 1.512 | 1.00 | |
| 358_D | 399_E | 1.511 | 1.00 | |
| 136_A | 194_K | 1.508 | 1.00 | |
| 475_L | 482_F | 1.507 | 1.00 | |
| 10_V | 201_A | 1.507 | 1.00 | |
| 15_A | 64_S | 1.506 | 1.00 | |
| 435_V | 443_I | 1.497 | 1.00 | |
| 125_Q | 128_Q | 1.496 | 1.00 | |
| 18_K | 55_M | 1.494 | 1.00 | |
| 14_V | 32_T | 1.49 | 1.00 | |
| 169_R | 200_V | 1.483 | 1.00 | |
| 265_A | 286_R | 1.481 | 1.00 | |
| 402_I | 413_V | 1.477 | 1.00 | |
| 213_R | 234_E | 1.476 | 1.00 | |
| 397_S | 400_T | 1.45 | 1.00 | |
| 272_L | 314_Y | 1.449 | 1.00 | |
| 80_T | 84_R | 1.438 | 1.00 | |
| 271_A | 316_Q | 1.435 | 1.00 | |
| 16_G | 55_M | 1.43 | 1.00 | |
| 133_C | 165_K | 1.429 | 1.00 | |
| 31_F | 220_T | 1.427 | 1.00 | |
| 287_R | 456_S | 1.424 | 1.00 | |
| 33_L | 39_R | 1.415 | 1.00 | |
| 376_Q | 379_T | 1.413 | 1.00 | |
| 270_R | 284_T | 1.408 | 1.00 | |
| 218_C | 230_D | 1.379 | 0.99 | |
| 57_T | 92_A | 1.373 | 0.99 | |
| 352_I | 363_L | 1.371 | 0.99 | |
| 190_S | 194_K | 1.347 | 0.99 | |
| 342_T | 428_L | 1.347 | 0.99 | |
| 196_S | 217_S | 1.344 | 0.99 | |
| 290_V | 447_V | 1.343 | 0.99 | |
| 269_V | 319_I | 1.339 | 0.99 | |
| 355_L | 359_E | 1.336 | 0.99 | |
| 151_S | 154_Q | 1.336 | 0.99 | |
| 194_K | 198_L | 1.336 | 0.99 | |
| 186_E | 214_R | 1.334 | 0.99 | |
| 356_G | 359_E | 1.332 | 0.99 | |
| 59_S | 94_Y | 1.326 | 0.99 | |
| 18_K | 51_T | 1.322 | 0.99 | |
| 285_L | 425_I | 1.321 | 0.99 | |
| 490_V | 494_E | 1.315 | 0.99 | |
| 206_S | 212_I | 1.314 | 0.99 | |
| 99_L | 147_V | 1.309 | 0.99 | |
| 383_L | 386_E | 1.307 | 0.99 | |
| 278_L | 281_I | 1.306 | 0.99 | |
| 385_E | 398_S | 1.304 | 0.99 | |
| 132_R | 136_A | 1.303 | 0.99 | |
| 487_H | 490_V | 1.302 | 0.99 | |
| 69_I | 170_V | 1.295 | 0.99 | |
| 53_I | 172_I | 1.288 | 0.99 | |
| 73_R | 79_A | 1.28 | 0.99 | |
| 357_V | 413_V | 1.275 | 0.99 | |
| 496_M | 499_I | 1.269 | 0.99 | |
| 276_P | 279_E | 1.268 | 0.99 | |
| 289_E | 472_D | 1.265 | 0.99 | |
| 447_V | 457_V | 1.259 | 0.99 | |
| 11_A | 69_I | 1.257 | 0.99 | |
| 400_T | 404_T | 1.248 | 0.99 | |
| 272_L | 307_A | 1.247 | 0.99 | |
| 385_E | 389_Q | 1.244 | 0.98 | |
| 321_I | 326_I | 1.243 | 0.98 | |
| 362_V | 380_I | 1.243 | 0.98 | |
| 194_K | 197_A | 1.236 | 0.98 | |
| 358_D | 398_S | 1.232 | 0.98 | |
| 68_W | 73_R | 1.23 | 0.98 | |
| 193_K | 196_S | 1.211 | 0.98 | |
| 401_P | 404_T | 1.197 | 0.98 | |
| 110_C | 130_A | 1.197 | 0.98 | |
| 19_R | 64_S | 1.196 | 0.98 | |
| 274_H | 315_E | 1.195 | 0.98 | |
| 9_P | 34_N | 1.193 | 0.98 | |
| 428_L | 447_V | 1.186 | 0.98 | |
| 382_R | 386_E | 1.185 | 0.98 | |
| 339_I | 425_I | 1.181 | 0.98 | |
| 55_M | 67_I | 1.178 | 0.98 | |
| 321_I | 425_I | 1.169 | 0.97 | |
| 237_S | 240_H | 1.165 | 0.97 | |
| 352_I | 355_L | 1.164 | 0.97 | |
| 186_E | 190_S | 1.164 | 0.97 | |
| 486_F | 498_A | 1.162 | 0.97 | |
| 53_I | 92_A | 1.159 | 0.97 | |
| 280_D | 481_T | 1.155 | 0.97 | |
| 265_A | 287_R | 1.155 | 0.97 | |
| 20_Y | 51_T | 1.153 | 0.97 | |
| 491_N | 494_E | 1.143 | 0.97 | |
| 106_A | 130_A | 1.142 | 0.97 | |
| 106_A | 127_A | 1.13 | 0.97 | |
| 37_E | 217_S | 1.127 | 0.97 | |
| 474_I | 490_V | 1.123 | 0.97 | |
| 360_N | 417_R | 1.118 | 0.96 | |
| 134_L | 143_P | 1.115 | 0.96 | |
| 291_L | 458_V | 1.113 | 0.96 | |
| 26_L | 29_V | 1.113 | 0.96 | |
| 137_L | 161_A | 1.109 | 0.96 | |
| 283_F | 304_L | 1.109 | 0.96 | |
| 17_N | 27_D | 1.109 | 0.96 | |
| 110_C | 126_M | 1.109 | 0.96 | |
| 55_M | 62_P | 1.108 | 0.96 | |
| 381_R | 385_E | 1.108 | 0.96 | |
| 150_L | 158_V | 1.097 | 0.96 | |
| 50_S | 54_R | 1.095 | 0.96 | |
| 155_K | 345_N | 1.094 | 0.96 | |
| 340_G | 423_S | 1.094 | 0.96 | |
| 293_I | 475_L | 1.094 | 0.96 | |
| 273_R | 279_E | 1.092 | 0.96 | |
| 18_K | 60_E | 1.092 | 0.96 | |
| 91_R | 168_P | 1.091 | 0.96 | |
| 100_V | 111_L | 1.089 | 0.96 | |
| 69_I | 90_V | 1.088 | 0.96 | |
| 131_Q | 143_P | 1.088 | 0.96 | |
| 16_G | 62_P | 1.084 | 0.96 | |
| 266_V | 456_S | 1.084 | 0.96 | |
| 195_M | 200_V | 1.08 | 0.95 | |
| 93_V | 163_V | 1.078 | 0.95 | |
| 379_T | 382_R | 1.071 | 0.95 | |
| 28_N | 226_Q | 1.064 | 0.95 | |
| 351_I | 402_I | 1.061 | 0.95 | |
| 274_H | 307_A | 1.057 | 0.95 | |
| 20_Y | 25_A | 1.054 | 0.95 | |
| 101_E | 155_K | 1.051 | 0.94 | |
| 135_Q | 140_D | 1.051 | 0.94 | |
| 35_K | 201_A | 1.05 | 0.94 | |
| 278_L | 307_A | 1.05 | 0.94 | |
| 216_A | 219_A | 1.047 | 0.94 | |
| 320_V | 325_K | 1.041 | 0.94 | |
| 127_A | 131_Q | 1.032 | 0.94 | |
| 307_A | 319_I | 1.032 | 0.94 | |
| 265_A | 320_V | 1.031 | 0.94 | |
| 294_A | 467_L | 1.03 | 0.94 | |
| 450_L | 455_K | 1.023 | 0.93 | |
| 189_I | 214_R | 1.018 | 0.93 | |
| 13_V | 67_I | 1.015 | 0.93 | |
| 167_E | 198_L | 1.013 | 0.93 | |
| 40_A | 212_I | 1.013 | 0.93 | |
| 72_T | 84_R | 1.004 | 0.93 | |
| 18_K | 63_D | 1.001 | 0.92 | |
| 11_A | 56_L | 1.001 | 0.92 | |
| 147_V | 158_V | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4finA | 2 | 0.9046 | 100 | 0.219 | Contact Map | 0.756 |
| 3g5uA | 2 | 0.9702 | 100 | 0.24 | Contact Map | 0.643 |
| 4f4cA | 1 | 0.9702 | 100 | 0.243 | Contact Map | 0.713 |
| 1yqtA | 1 | 0.9225 | 100 | 0.281 | Contact Map | 0.651 |
| 2iw3A | 2 | 0.8847 | 100 | 0.285 | Contact Map | 0.72 |
| 3bk7A | 1 | 0.9205 | 100 | 0.286 | Contact Map | 0.619 |
| 3ozxA | 2 | 0.8946 | 100 | 0.294 | Contact Map | 0.677 |
| 3j16B | 1 | 0.9165 | 100 | 0.305 | Contact Map | 0.481 |
| 3ux8A | 1 | 0.9443 | 100 | 0.31 | Contact Map | 0.589 |
| 2vf7A | 3 | 0.9523 | 100 | 0.424 | Contact Map | 0.561 |
Sequence Conservation (Image Generated using WebLogo v3)