| UniProt: | P0AAF3 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10058 | ||
| Length: | 504 (492) | ||
| Sequences: | 13966 | ||
| Seq/Len: | 28.39 |
| ARAG
Paralog alert: 0.93 [within 20: 0.27] - ratio of genomes with paralogs Cluster includes: ALSA ARAG GSIA LSRA MGLA MODF RBSA UUP XYLG YBHF YBIT YEJF YHES YJJK YPHE YTFR |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 34_Q | 212_A | 4.458 | 1.00 | |
| 12_G | 25_D | 4.349 | 1.00 | |
| 265_A | 274_P | 4.344 | 1.00 | |
| 262_R | 278_A | 4.128 | 1.00 | |
| 24_T | 220_R | 3.946 | 1.00 | |
| 264_D | 312_Q | 3.908 | 1.00 | |
| 283_E | 468_R | 3.736 | 1.00 | |
| 11_R | 63_S | 3.668 | 1.00 | |
| 299_M | 455_A | 3.578 | 1.00 | |
| 263_L | 266_V | 3.377 | 1.00 | |
| 63_S | 70_E | 3.333 | 1.00 | |
| 36_H | 214_T | 3.316 | 1.00 | |
| 9_S | 29_D | 3.21 | 1.00 | |
| 262_R | 314_Y | 3.202 | 1.00 | |
| 10_F | 13_I | 3.192 | 1.00 | |
| 21_K | 24_T | 2.963 | 1.00 | |
| 312_Q | 319_P | 2.924 | 1.00 | |
| 300_K | 306_T | 2.861 | 1.00 | |
| 273_T | 476_E | 2.718 | 1.00 | |
| 37_A | 210_S | 2.7 | 1.00 | |
| 9_S | 65_V | 2.612 | 1.00 | |
| 286_G | 466_A | 2.612 | 1.00 | |
| 285_V | 470_V | 2.6 | 1.00 | |
| 123_E | 126_L | 2.562 | 1.00 | |
| 116_N | 119_L | 2.55 | 1.00 | |
| 383_I | 393_A | 2.509 | 1.00 | |
| 263_L | 277_L | 2.506 | 1.00 | |
| 67_N | 163_K | 2.496 | 1.00 | |
| 316_D | 419_K | 2.477 | 1.00 | |
| 332_G | 419_K | 2.463 | 1.00 | |
| 227_D | 230_Q | 2.46 | 1.00 | |
| 14_G | 25_D | 2.436 | 1.00 | |
| 50_L | 199_V | 2.389 | 1.00 | |
| 265_A | 276_S | 2.324 | 1.00 | |
| 268_A | 301_G | 2.318 | 1.00 | |
| 187_R | 208_A | 2.296 | 1.00 | |
| 268_A | 309_T | 2.262 | 1.00 | |
| 121_N | 138_D | 2.257 | 1.00 | |
| 139_T | 143_Y | 2.253 | 1.00 | |
| 264_D | 314_Y | 2.245 | 1.00 | |
| 130_H | 192_E | 2.243 | 1.00 | |
| 12_G | 27_S | 2.222 | 1.00 | |
| 259_E | 262_R | 2.214 | 1.00 | |
| 456_S | 462_V | 2.211 | 1.00 | |
| 16_T | 21_K | 2.206 | 1.00 | |
| 301_G | 308_I | 2.096 | 1.00 | |
| 83_G | 163_K | 2.089 | 1.00 | |
| 281_S | 419_K | 2.074 | 1.00 | |
| 17_F | 57_Y | 2.06 | 1.00 | |
| 119_L | 123_E | 2.055 | 1.00 | |
| 298_L | 472_M | 1.996 | 1.00 | |
| 348_V | 398_M | 1.983 | 1.00 | |
| 299_M | 422_L | 1.97 | 1.00 | |
| 267_K | 274_P | 1.953 | 1.00 | |
| 10_F | 28_F | 1.941 | 1.00 | |
| 14_G | 21_K | 1.938 | 1.00 | |
| 123_E | 161_N | 1.933 | 1.00 | |
| 267_K | 310_A | 1.923 | 1.00 | |
| 470_V | 480_E | 1.917 | 1.00 | |
| 444_A | 448_Q | 1.897 | 1.00 | |
| 136_D | 139_T | 1.877 | 1.00 | |
| 10_F | 53_L | 1.842 | 1.00 | |
| 258_E | 281_S | 1.827 | 1.00 | |
| 279_V | 285_V | 1.827 | 1.00 | |
| 73_F | 82_A | 1.826 | 1.00 | |
| 31_Y | 34_Q | 1.825 | 1.00 | |
| 125_G | 129_K | 1.798 | 1.00 | |
| 98_T | 101_E | 1.782 | 1.00 | |
| 210_S | 228_M | 1.781 | 1.00 | |
| 85_A | 157_A | 1.765 | 1.00 | |
| 214_T | 221_Y | 1.762 | 1.00 | |
| 280_R | 283_E | 1.739 | 1.00 | |
| 122_Y | 126_L | 1.723 | 1.00 | |
| 454_F | 465_V | 1.718 | 1.00 | |
| 75_D | 78_A | 1.717 | 1.00 | |
| 264_D | 276_S | 1.706 | 1.00 | |
| 103_I | 159_A | 1.704 | 1.00 | |
| 382_H | 415_S | 1.695 | 1.00 | |
| 286_G | 462_V | 1.694 | 1.00 | |
| 186_I | 196_I | 1.688 | 1.00 | |
| 96_E | 142_K | 1.675 | 1.00 | |
| 11_R | 65_V | 1.672 | 1.00 | |
| 277_L | 470_V | 1.669 | 1.00 | |
| 381_H | 385_S | 1.659 | 1.00 | |
| 14_G | 61_T | 1.659 | 1.00 | |
| 303_F | 422_L | 1.656 | 1.00 | |
| 30_C | 164_I | 1.632 | 1.00 | |
| 32_A | 163_K | 1.626 | 1.00 | |
| 279_V | 451_A | 1.619 | 1.00 | |
| 35_V | 186_I | 1.584 | 1.00 | |
| 140_P | 143_Y | 1.584 | 1.00 | |
| 235_A | 238_Q | 1.582 | 1.00 | |
| 70_E | 73_F | 1.574 | 1.00 | |
| 419_K | 450_V | 1.573 | 1.00 | |
| 223_K | 239_A | 1.57 | 1.00 | |
| 382_H | 411_G | 1.557 | 1.00 | |
| 352_R | 394_E | 1.555 | 1.00 | |
| 87_I | 167_F | 1.541 | 1.00 | |
| 400_L | 408_A | 1.539 | 1.00 | |
| 385_S | 444_A | 1.539 | 1.00 | |
| 479_G | 494_L | 1.538 | 1.00 | |
| 383_I | 390_T | 1.536 | 1.00 | |
| 225_F | 231_V | 1.53 | 1.00 | |
| 470_V | 477_I | 1.522 | 1.00 | |
| 430_I | 438_I | 1.508 | 1.00 | |
| 74_S | 78_A | 1.504 | 1.00 | |
| 270_G | 273_T | 1.501 | 1.00 | |
| 11_R | 29_D | 1.501 | 1.00 | |
| 397_I | 408_A | 1.499 | 1.00 | |
| 392_G | 395_Q | 1.498 | 1.00 | |
| 259_E | 278_A | 1.494 | 1.00 | |
| 263_L | 302_M | 1.491 | 1.00 | |
| 130_H | 188_E | 1.49 | 1.00 | |
| 259_E | 280_R | 1.489 | 1.00 | |
| 15_K | 52_I | 1.484 | 1.00 | |
| 163_K | 194_R | 1.482 | 1.00 | |
| 266_V | 308_I | 1.479 | 1.00 | |
| 7_Y | 195_V | 1.477 | 1.00 | |
| 12_G | 61_T | 1.468 | 1.00 | |
| 371_N | 374_W | 1.462 | 1.00 | |
| 346_I | 357_I | 1.461 | 1.00 | |
| 127_Q | 159_A | 1.453 | 1.00 | |
| 11_R | 27_S | 1.453 | 1.00 | |
| 13_I | 52_I | 1.446 | 1.00 | |
| 265_A | 310_A | 1.437 | 1.00 | |
| 30_C | 36_H | 1.423 | 1.00 | |
| 268_A | 306_T | 1.411 | 1.00 | |
| 264_D | 278_A | 1.409 | 1.00 | |
| 281_S | 451_A | 1.405 | 0.99 | |
| 212_A | 224_T | 1.386 | 0.99 | |
| 28_F | 214_T | 1.383 | 0.99 | |
| 468_R | 480_E | 1.374 | 0.99 | |
| 119_L | 122_Y | 1.372 | 0.99 | |
| 279_V | 420_V | 1.371 | 0.99 | |
| 284_I | 442_I | 1.368 | 0.99 | |
| 54_S | 86_I | 1.365 | 0.99 | |
| 56_N | 88_Y | 1.362 | 0.99 | |
| 184_R | 188_E | 1.344 | 0.99 | |
| 350_S | 353_D | 1.341 | 0.99 | |
| 126_L | 130_H | 1.34 | 0.99 | |
| 93_L | 141_L | 1.335 | 0.99 | |
| 145_S | 148_Q | 1.332 | 0.99 | |
| 263_L | 313_V | 1.331 | 0.99 | |
| 15_K | 48_T | 1.323 | 0.99 | |
| 180_D | 208_A | 1.32 | 0.99 | |
| 272_R | 275_I | 1.319 | 0.99 | |
| 349_H | 353_D | 1.317 | 0.99 | |
| 190_R | 211_D | 1.317 | 0.99 | |
| 66_I | 164_I | 1.311 | 0.99 | |
| 380_D | 393_A | 1.31 | 0.99 | |
| 200_S | 206_I | 1.31 | 0.99 | |
| 188_E | 192_E | 1.309 | 0.99 | |
| 492_L | 495_A | 1.309 | 0.99 | |
| 486_A | 490_Q | 1.302 | 0.99 | |
| 336_C | 423_L | 1.302 | 0.99 | |
| 378_N | 381_H | 1.286 | 0.99 | |
| 50_L | 166_A | 1.277 | 0.99 | |
| 356_N | 375_E | 1.267 | 0.99 | |
| 8_L | 66_I | 1.264 | 0.99 | |
| 351_V | 408_A | 1.262 | 0.99 | |
| 442_I | 452_V | 1.259 | 0.99 | |
| 352_R | 393_A | 1.257 | 0.99 | |
| 380_D | 384_R | 1.248 | 0.99 | |
| 207_F | 229_Q | 1.24 | 0.98 | |
| 395_Q | 399_N | 1.237 | 0.98 | |
| 283_E | 467_D | 1.236 | 0.98 | |
| 315_I | 320_I | 1.225 | 0.98 | |
| 396_L | 399_N | 1.213 | 0.98 | |
| 188_E | 191_K | 1.21 | 0.98 | |
| 266_V | 301_G | 1.209 | 0.98 | |
| 104_Y | 124_A | 1.203 | 0.98 | |
| 65_V | 70_E | 1.203 | 0.98 | |
| 377_N | 381_H | 1.201 | 0.98 | |
| 483_H | 486_A | 1.2 | 0.98 | |
| 16_T | 61_T | 1.2 | 0.98 | |
| 187_R | 190_R | 1.196 | 0.98 | |
| 50_L | 86_I | 1.187 | 0.98 | |
| 333_M | 420_V | 1.186 | 0.98 | |
| 52_I | 64_V | 1.183 | 0.98 | |
| 6_P | 31_Y | 1.181 | 0.98 | |
| 354_N | 412_R | 1.17 | 0.97 | |
| 423_L | 442_I | 1.168 | 0.97 | |
| 315_I | 420_V | 1.164 | 0.97 | |
| 180_D | 184_R | 1.153 | 0.97 | |
| 481_L | 494_L | 1.15 | 0.97 | |
| 346_I | 349_H | 1.149 | 0.97 | |
| 125_G | 137_P | 1.144 | 0.97 | |
| 482_L | 485_Q | 1.142 | 0.97 | |
| 131_L | 155_A | 1.137 | 0.97 | |
| 100_A | 124_A | 1.134 | 0.97 | |
| 17_F | 48_T | 1.129 | 0.97 | |
| 376_E | 380_D | 1.128 | 0.97 | |
| 100_A | 121_N | 1.127 | 0.97 | |
| 34_Q | 211_D | 1.125 | 0.97 | |
| 267_K | 273_T | 1.119 | 0.96 | |
| 14_G | 24_T | 1.116 | 0.96 | |
| 274_P | 476_E | 1.115 | 0.96 | |
| 149_W | 339_D | 1.113 | 0.96 | |
| 232_D | 235_A | 1.113 | 0.96 | |
| 52_I | 59_P | 1.112 | 0.96 | |
| 15_K | 57_Y | 1.111 | 0.96 | |
| 128_L | 137_P | 1.109 | 0.96 | |
| 259_E | 281_S | 1.108 | 0.96 | |
| 487_D | 490_Q | 1.107 | 0.96 | |
| 94_V | 105_L | 1.104 | 0.96 | |
| 66_I | 84_V | 1.103 | 0.96 | |
| 23_L | 26_I | 1.097 | 0.96 | |
| 285_V | 453_L | 1.092 | 0.96 | |
| 301_G | 313_V | 1.09 | 0.96 | |
| 85_A | 162_A | 1.09 | 0.96 | |
| 104_Y | 120_L | 1.089 | 0.96 | |
| 144_L | 152_V | 1.082 | 0.96 | |
| 374_W | 377_N | 1.08 | 0.95 | |
| 345_I | 397_I | 1.079 | 0.95 | |
| 334_M | 418_M | 1.077 | 0.95 | |
| 25_D | 220_R | 1.077 | 0.95 | |
| 272_R | 301_G | 1.077 | 0.95 | |
| 210_S | 213_I | 1.076 | 0.95 | |
| 78_A | 81_N | 1.073 | 0.95 | |
| 13_I | 59_P | 1.073 | 0.95 | |
| 121_N | 125_G | 1.073 | 0.95 | |
| 17_F | 22_A | 1.069 | 0.95 | |
| 277_L | 298_L | 1.069 | 0.95 | |
| 287_L | 470_V | 1.068 | 0.95 | |
| 95_P | 149_W | 1.065 | 0.95 | |
| 32_A | 195_V | 1.063 | 0.95 | |
| 259_E | 314_Y | 1.051 | 0.94 | |
| 129_K | 134_D | 1.048 | 0.94 | |
| 87_I | 157_A | 1.043 | 0.94 | |
| 47_S | 51_K | 1.042 | 0.94 | |
| 141_L | 152_V | 1.036 | 0.94 | |
| 16_T | 60_T | 1.033 | 0.94 | |
| 10_F | 64_V | 1.033 | 0.94 | |
| 260_R | 316_D | 1.033 | 0.94 | |
| 469_I | 486_A | 1.031 | 0.94 | |
| 260_R | 451_A | 1.031 | 0.94 | |
| 69_Q | 78_A | 1.03 | 0.94 | |
| 8_L | 53_L | 1.029 | 0.94 | |
| 37_A | 206_I | 1.027 | 0.94 | |
| 383_I | 388_I | 1.008 | 0.93 | |
| 183_F | 208_A | 1.007 | 0.93 | |
| 445_L | 450_V | 1.007 | 0.93 | |
| 314_Y | 319_P | 1.006 | 0.93 | |
| 15_K | 60_T | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4finA | 2 | 0.9107 | 100 | 0.215 | Contact Map | 0.756 |
| 3g5uA | 2 | 0.9663 | 100 | 0.235 | Contact Map | 0.645 |
| 4f4cA | 1 | 0.9663 | 100 | 0.237 | Contact Map | 0.711 |
| 1yqtA | 1 | 0.9226 | 100 | 0.282 | Contact Map | 0.65 |
| 2iw3A | 2 | 0.875 | 100 | 0.288 | Contact Map | 0.728 |
| 3bk7A | 1 | 0.9226 | 100 | 0.293 | Contact Map | 0.626 |
| 3ozxA | 2 | 0.9028 | 100 | 0.295 | Contact Map | 0.669 |
| 3j16B | 1 | 0.9206 | 100 | 0.31 | Contact Map | 0.479 |
| 3ux8A | 1 | 0.9464 | 100 | 0.311 | Contact Map | 0.584 |
| 2vf7A | 3 | 0.9663 | 100 | 0.42 | Contact Map | 0.561 |
Sequence Conservation (Image Generated using WebLogo v3)