| UniProt: | P77257 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13806 | ||
| Length: | 511 (492) | ||
| Sequences: | 14848 | ||
| Seq/Len: | 30.18 |
| LSRA
Paralog alert: 0.93 [within 20: 0.28] - ratio of genomes with paralogs Cluster includes: ALSA ARAG GSIA LSRA MGLA MODF RBSA UUP XYLG YBHF YBIT YEJF YHES YJJK YPHE YTFR |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 38_E | 209_R | 4.467 | 1.00 | |
| 16_S | 29_G | 4.452 | 1.00 | |
| 273_N | 281_N | 4.384 | 1.00 | |
| 270_T | 285_T | 4.239 | 1.00 | |
| 28_K | 217_T | 3.995 | 1.00 | |
| 272_E | 319_R | 3.932 | 1.00 | |
| 290_E | 472_R | 3.785 | 1.00 | |
| 15_R | 67_T | 3.697 | 1.00 | |
| 306_A | 459_I | 3.545 | 1.00 | |
| 13_C | 33_T | 3.43 | 1.00 | |
| 67_T | 74_N | 3.385 | 1.00 | |
| 40_H | 211_S | 3.367 | 1.00 | |
| 271_L | 274_L | 3.363 | 1.00 | |
| 14_A | 17_V | 3.206 | 1.00 | |
| 270_T | 321_M | 3.201 | 1.00 | |
| 319_R | 326_E | 3.079 | 1.00 | |
| 25_N | 28_K | 3.057 | 1.00 | |
| 307_E | 313_R | 2.828 | 1.00 | |
| 292_L | 474_Y | 2.778 | 1.00 | |
| 280_R | 480_E | 2.718 | 1.00 | |
| 13_C | 69_E | 2.648 | 1.00 | |
| 41_A | 207_A | 2.622 | 1.00 | |
| 293_G | 470_A | 2.582 | 1.00 | |
| 223_K | 226_E | 2.569 | 1.00 | |
| 120_K | 123_N | 2.561 | 1.00 | |
| 18_Y | 29_G | 2.555 | 1.00 | |
| 339_G | 423_Q | 2.499 | 1.00 | |
| 387_R | 397_P | 2.488 | 1.00 | |
| 271_L | 284_L | 2.479 | 1.00 | |
| 71_E | 160_R | 2.449 | 1.00 | |
| 323_N | 423_Q | 2.436 | 1.00 | |
| 54_M | 196_I | 2.432 | 1.00 | |
| 272_E | 321_M | 2.361 | 1.00 | |
| 273_N | 283_S | 2.345 | 1.00 | |
| 184_Q | 205_Q | 2.273 | 1.00 | |
| 113_K | 116_L | 2.241 | 1.00 | |
| 136_S | 140_S | 2.233 | 1.00 | |
| 276_G | 308_T | 2.232 | 1.00 | |
| 118_M | 135_H | 2.222 | 1.00 | |
| 276_G | 316_R | 2.222 | 1.00 | |
| 16_S | 31_D | 2.222 | 1.00 | |
| 460_S | 466_I | 2.208 | 1.00 | |
| 20_Q | 25_N | 2.188 | 1.00 | |
| 127_A | 189_T | 2.158 | 1.00 | |
| 275_T | 281_N | 2.152 | 1.00 | |
| 267_P | 270_T | 2.127 | 1.00 | |
| 116_L | 120_K | 2.106 | 1.00 | |
| 288_A | 423_Q | 2.091 | 1.00 | |
| 87_G | 160_R | 2.035 | 1.00 | |
| 308_T | 315_L | 2.03 | 1.00 | |
| 35_H | 38_E | 2.015 | 1.00 | |
| 120_K | 158_D | 2.001 | 1.00 | |
| 306_A | 426_I | 1.993 | 1.00 | |
| 204_R | 225_S | 1.991 | 1.00 | |
| 355_D | 402_R | 1.968 | 1.00 | |
| 305_L | 476_M | 1.96 | 1.00 | |
| 21_Y | 61_T | 1.957 | 1.00 | |
| 275_T | 317_G | 1.938 | 1.00 | |
| 18_Y | 25_N | 1.925 | 1.00 | |
| 286_L | 292_L | 1.877 | 1.00 | |
| 287_N | 290_E | 1.834 | 1.00 | |
| 14_A | 32_F | 1.834 | 1.00 | |
| 211_S | 218_I | 1.827 | 1.00 | |
| 77_R | 86_L | 1.826 | 1.00 | |
| 207_A | 224_T | 1.817 | 1.00 | |
| 14_A | 57_I | 1.805 | 1.00 | |
| 15_R | 69_E | 1.797 | 1.00 | |
| 266_T | 288_A | 1.796 | 1.00 | |
| 119_Q | 123_N | 1.772 | 1.00 | |
| 474_Y | 485_A | 1.763 | 1.00 | |
| 79_T | 82_H | 1.757 | 1.00 | |
| 448_S | 452_Q | 1.752 | 1.00 | |
| 107_I | 156_M | 1.748 | 1.00 | |
| 133_D | 136_S | 1.736 | 1.00 | |
| 18_Y | 65_S | 1.727 | 1.00 | |
| 89_Y | 154_G | 1.724 | 1.00 | |
| 458_L | 469_M | 1.719 | 1.00 | |
| 102_S | 105_E | 1.717 | 1.00 | |
| 284_L | 474_Y | 1.709 | 1.00 | |
| 122_K | 126_A | 1.707 | 1.00 | |
| 100_S | 139_G | 1.686 | 1.00 | |
| 272_E | 283_S | 1.667 | 1.00 | |
| 36_Q | 160_R | 1.66 | 1.00 | |
| 74_N | 77_R | 1.657 | 1.00 | |
| 386_Y | 419_E | 1.645 | 1.00 | |
| 385_R | 389_A | 1.624 | 1.00 | |
| 359_A | 398_E | 1.597 | 1.00 | |
| 183_L | 193_I | 1.582 | 1.00 | |
| 293_G | 466_I | 1.578 | 1.00 | |
| 389_A | 448_S | 1.569 | 1.00 | |
| 220_L | 235_A | 1.569 | 1.00 | |
| 423_Q | 454_V | 1.566 | 1.00 | |
| 286_L | 455_A | 1.563 | 1.00 | |
| 310_Y | 426_I | 1.562 | 1.00 | |
| 91_V | 164_L | 1.551 | 1.00 | |
| 160_R | 191_V | 1.546 | 1.00 | |
| 386_Y | 415_A | 1.538 | 1.00 | |
| 34_L | 161_I | 1.537 | 1.00 | |
| 137_L | 140_S | 1.536 | 1.00 | |
| 396_Q | 399_Q | 1.536 | 1.00 | |
| 209_R | 221_S | 1.535 | 1.00 | |
| 39_V | 183_L | 1.533 | 1.00 | |
| 16_S | 65_S | 1.52 | 1.00 | |
| 404_L | 412_I | 1.498 | 1.00 | |
| 387_R | 394_F | 1.493 | 1.00 | |
| 78_L | 82_H | 1.493 | 1.00 | |
| 434_V | 442_I | 1.49 | 1.00 | |
| 127_A | 185_E | 1.485 | 1.00 | |
| 483_H | 499_V | 1.479 | 1.00 | |
| 271_L | 309_L | 1.479 | 1.00 | |
| 274_L | 315_L | 1.474 | 1.00 | |
| 11_L | 192_G | 1.468 | 1.00 | |
| 19_K | 56_I | 1.467 | 1.00 | |
| 15_R | 31_D | 1.467 | 1.00 | |
| 267_P | 285_T | 1.467 | 1.00 | |
| 273_N | 317_G | 1.459 | 1.00 | |
| 15_R | 33_T | 1.457 | 1.00 | |
| 375_K | 378_K | 1.451 | 1.00 | |
| 34_L | 40_H | 1.45 | 1.00 | |
| 222_G | 227_L | 1.436 | 1.00 | |
| 17_V | 56_I | 1.435 | 1.00 | |
| 474_Y | 481_I | 1.432 | 1.00 | |
| 272_E | 285_T | 1.431 | 1.00 | |
| 401_A | 412_I | 1.421 | 1.00 | |
| 353_N | 364_A | 1.409 | 1.00 | |
| 267_P | 287_N | 1.407 | 0.99 | |
| 124_L | 156_M | 1.399 | 0.99 | |
| 356_A | 360_W | 1.398 | 0.99 | |
| 54_M | 163_I | 1.395 | 0.99 | |
| 181_S | 185_E | 1.393 | 0.99 | |
| 58_A | 90_L | 1.387 | 0.99 | |
| 19_K | 52_T | 1.387 | 0.99 | |
| 288_A | 455_A | 1.379 | 0.99 | |
| 384_E | 397_P | 1.365 | 0.99 | |
| 142_D | 145_D | 1.363 | 0.99 | |
| 497_M | 500_A | 1.354 | 0.99 | |
| 276_G | 313_R | 1.35 | 0.99 | |
| 60_I | 92_P | 1.35 | 0.99 | |
| 343_L | 427_V | 1.344 | 0.99 | |
| 123_N | 127_A | 1.341 | 0.99 | |
| 382_T | 385_R | 1.334 | 0.99 | |
| 357_S | 360_W | 1.332 | 0.99 | |
| 286_L | 424_V | 1.33 | 0.99 | |
| 279_F | 282_V | 1.328 | 0.99 | |
| 70_I | 161_I | 1.326 | 0.99 | |
| 97_L | 138_A | 1.324 | 0.99 | |
| 271_L | 320_I | 1.322 | 0.99 | |
| 116_L | 119_Q | 1.318 | 0.99 | |
| 32_F | 211_S | 1.318 | 0.99 | |
| 290_E | 471_D | 1.31 | 0.99 | |
| 177_E | 205_Q | 1.31 | 0.99 | |
| 491_I | 495_T | 1.303 | 0.99 | |
| 187_L | 208_D | 1.303 | 0.99 | |
| 197_S | 203_I | 1.297 | 0.99 | |
| 291_I | 446_L | 1.295 | 0.99 | |
| 185_E | 189_T | 1.281 | 0.99 | |
| 487_T | 490_D | 1.28 | 0.99 | |
| 184_Q | 187_L | 1.27 | 0.99 | |
| 322_L | 424_V | 1.265 | 0.99 | |
| 384_E | 388_R | 1.252 | 0.99 | |
| 56_I | 68_L | 1.243 | 0.98 | |
| 222_G | 226_E | 1.24 | 0.98 | |
| 185_E | 188_A | 1.233 | 0.98 | |
| 399_Q | 403_T | 1.228 | 0.98 | |
| 359_A | 397_P | 1.225 | 0.98 | |
| 12_L | 70_I | 1.225 | 0.98 | |
| 381_A | 385_R | 1.217 | 0.98 | |
| 177_E | 181_S | 1.213 | 0.98 | |
| 274_L | 308_T | 1.207 | 0.98 | |
| 56_I | 63_A | 1.207 | 0.98 | |
| 486_L | 499_V | 1.2 | 0.98 | |
| 118_M | 122_K | 1.199 | 0.98 | |
| 38_E | 208_D | 1.192 | 0.98 | |
| 231_D | 234_Q | 1.188 | 0.98 | |
| 363_C | 379_D | 1.181 | 0.98 | |
| 20_Q | 65_S | 1.177 | 0.98 | |
| 400_A | 403_T | 1.175 | 0.98 | |
| 104_K | 121_M | 1.171 | 0.98 | |
| 446_L | 456_V | 1.165 | 0.97 | |
| 82_H | 85_Q | 1.163 | 0.97 | |
| 340_L | 424_V | 1.162 | 0.97 | |
| 27_L | 30_I | 1.16 | 0.97 | |
| 186_L | 191_V | 1.159 | 0.97 | |
| 108_L | 121_M | 1.156 | 0.97 | |
| 488_E | 491_I | 1.155 | 0.97 | |
| 69_E | 74_N | 1.154 | 0.97 | |
| 361_N | 416_K | 1.149 | 0.97 | |
| 10_P | 35_H | 1.149 | 0.97 | |
| 21_Y | 52_T | 1.149 | 0.97 | |
| 29_G | 217_T | 1.148 | 0.97 | |
| 122_K | 134_L | 1.147 | 0.97 | |
| 427_V | 446_L | 1.146 | 0.97 | |
| 492_N | 495_T | 1.143 | 0.97 | |
| 108_L | 117_S | 1.143 | 0.97 | |
| 358_L | 412_I | 1.139 | 0.97 | |
| 279_F | 308_T | 1.135 | 0.97 | |
| 17_V | 63_A | 1.135 | 0.97 | |
| 275_T | 280_R | 1.131 | 0.97 | |
| 91_V | 154_G | 1.129 | 0.97 | |
| 352_L | 401_A | 1.126 | 0.97 | |
| 281_N | 480_E | 1.125 | 0.97 | |
| 18_Y | 28_K | 1.124 | 0.97 | |
| 54_M | 90_L | 1.111 | 0.96 | |
| 353_N | 356_A | 1.11 | 0.96 | |
| 268_V | 455_A | 1.109 | 0.96 | |
| 378_K | 381_A | 1.107 | 0.96 | |
| 294_L | 474_Y | 1.103 | 0.96 | |
| 128_L | 152_L | 1.102 | 0.96 | |
| 21_Y | 26_V | 1.099 | 0.96 | |
| 234_Q | 240_V | 1.09 | 0.96 | |
| 380_N | 384_E | 1.089 | 0.96 | |
| 292_L | 457_L | 1.089 | 0.96 | |
| 141_L | 149_V | 1.084 | 0.96 | |
| 321_M | 326_E | 1.078 | 0.95 | |
| 125_L | 134_L | 1.075 | 0.95 | |
| 146_R | 346_D | 1.073 | 0.95 | |
| 341_V | 422_P | 1.073 | 0.95 | |
| 19_K | 61_T | 1.07 | 0.95 | |
| 104_K | 135_H | 1.064 | 0.95 | |
| 322_L | 327_I | 1.062 | 0.95 | |
| 51_S | 55_K | 1.062 | 0.95 | |
| 99_P | 146_R | 1.061 | 0.95 | |
| 89_Y | 159_S | 1.057 | 0.95 | |
| 207_A | 210_I | 1.057 | 0.95 | |
| 36_Q | 192_G | 1.054 | 0.95 | |
| 70_I | 88_I | 1.051 | 0.94 | |
| 20_Q | 64_D | 1.05 | 0.94 | |
| 284_L | 305_L | 1.046 | 0.94 | |
| 228_S | 231_D | 1.045 | 0.94 | |
| 421_S | 452_Q | 1.042 | 0.94 | |
| 180_F | 205_Q | 1.041 | 0.94 | |
| 104_K | 118_M | 1.034 | 0.94 | |
| 40_H | 221_S | 1.033 | 0.94 | |
| 41_A | 203_I | 1.031 | 0.94 | |
| 295_A | 466_I | 1.029 | 0.94 | |
| 268_V | 323_N | 1.028 | 0.94 | |
| 267_P | 288_A | 1.024 | 0.93 | |
| 421_S | 454_V | 1.024 | 0.93 | |
| 308_T | 320_I | 1.023 | 0.93 | |
| 466_I | 470_A | 1.022 | 0.93 | |
| 73_N | 82_H | 1.02 | 0.93 | |
| 126_A | 131_Q | 1.006 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4finA | 2 | 0.9041 | 100 | 0.225 | Contact Map | 0.749 |
| 3g5uA | 2 | 0.9746 | 100 | 0.242 | Contact Map | 0.643 |
| 4f4cA | 1 | 0.9706 | 100 | 0.244 | Contact Map | 0.715 |
| 1yqtA | 1 | 0.9374 | 100 | 0.289 | Contact Map | 0.656 |
| 2iw3A | 2 | 0.8767 | 100 | 0.3 | Contact Map | 0.724 |
| 3bk7A | 1 | 0.9393 | 100 | 0.302 | Contact Map | 0.634 |
| 3ozxA | 2 | 0.9119 | 100 | 0.306 | Contact Map | 0.661 |
| 3ux8A | 1 | 0.9335 | 100 | 0.319 | Contact Map | 0.583 |
| 3j16B | 1 | 0.9276 | 100 | 0.325 | Contact Map | 0.477 |
| 2vf7A | 3 | 0.9491 | 100 | 0.432 | Contact Map | 0.561 |
Sequence Conservation (Image Generated using WebLogo v3)