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MODF - Putative molybdenum transport ATP-binding protein ModF
UniProt: P31060 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11677
Length: 490 (474)
Sequences: 14963
Seq/Len: 31.57
MODF
Paralog alert: 0.94 [within 20: 0.28] - ratio of genomes with paralogs
Cluster includes: ALSA ARAG GSIA LSRA MGLA MODF RBSA UUP XYLG YBHF YBIT YEJF YHES YJJK YPHE YTFR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
30_D 204_F 5.042 1.00
265_N 278_N 4.911 1.00
262_V 282_Q 4.681 1.00
22_P 212_T 4.278 1.00
303_L 458_V 4.137 1.00
32_W 206_G 3.881 1.00
287_E 472_R 3.845 1.00
263_L 266_G 3.841 1.00
19_L 22_P 3.443 1.00
264_N 317_D 3.02 1.00
33_A 202_V 2.968 1.00
108_D 111_K 2.933 1.00
115_R 118_Q 2.928 1.00
218_A 221_E 2.898 1.00
289_W 474_E 2.868 1.00
263_L 281_W 2.819 1.00
385_L 395_A 2.819 1.00
290_Q 470_T 2.788 1.00
199_P 220_E 2.787 1.00
268_V 305_L 2.769 1.00
317_D 324_R 2.74 1.00
46_A 191_V 2.698 1.00
304_S 310_H 2.675 1.00
131_R 135_Y 2.619 1.00
179_A 200_E 2.592 1.00
265_N 280_S 2.591 1.00
122_Q 184_S 2.571 1.00
111_K 115_R 2.536 1.00
113_A 130_D 2.535 1.00
59_E 66_H 2.516 1.00
285_P 421_T 2.445 1.00
14_S 19_L 2.429 1.00
262_V 319_T 2.41 1.00
446_V 450_E 2.365 1.00
259_P 262_V 2.333 1.00
321_F 421_T 2.294 1.00
63_Q 155_D 2.292 1.00
115_R 153_E 2.274 1.00
12_R 23_Q 2.261 1.00
303_L 424_I 2.246 1.00
267_V 278_N 2.245 1.00
274_P 277_N 2.212 1.00
302_L 476_V 2.183 1.00
15_D 53_L 2.181 1.00
202_V 219_K 2.163 1.00
206_G 213_L 2.121 1.00
264_N 327_S 2.116 1.00
117_M 121_Q 2.061 1.00
258_E 285_P 2.016 1.00
284_N 287_E 1.992 1.00
383_Q 387_I 1.99 1.00
283_V 289_W 1.989 1.00
264_N 280_S 1.982 1.00
114_P 118_Q 1.951 1.00
122_Q 180_S 1.944 1.00
132_R 135_Y 1.929 1.00
307_T 424_I 1.902 1.00
178_L 188_L 1.898 1.00
12_R 19_L 1.874 1.00
457_F 469_I 1.873 1.00
421_T 453_T 1.867 1.00
399_F 410_A 1.859 1.00
28_A 155_D 1.855 1.00
31_S 178_L 1.852 1.00
268_V 324_R 1.801 1.00
394_T 397_A 1.786 1.00
384_W 417_V 1.781 1.00
283_V 454_Q 1.774 1.00
459_S 466_P 1.772 1.00
111_K 114_P 1.768 1.00
432_L 440_I 1.755 1.00
217_G 222_L 1.744 1.00
281_W 474_E 1.738 1.00
155_D 186_I 1.729 1.00
128_L 131_R 1.729 1.00
118_Q 122_Q 1.719 1.00
384_W 413_V 1.719 1.00
385_L 392_K 1.718 1.00
259_P 284_N 1.707 1.00
119_L 151_M 1.702 1.00
215_E 230_Q 1.693 1.00
387_I 446_V 1.67 1.00
259_P 282_Q 1.661 1.00
8_Q 23_Q 1.652 1.00
402_L 410_A 1.648 1.00
121_Q 126_T 1.643 1.00
10_T 23_Q 1.624 1.00
180_S 184_S 1.622 1.00
263_L 306_V 1.607 1.00
264_N 282_Q 1.601 1.00
382_Q 395_A 1.599 1.00
397_A 401_S 1.593 1.00
179_A 182_H 1.592 1.00
285_P 454_Q 1.586 1.00
46_A 158_I 1.585 1.00
172_Q 200_E 1.576 1.00
204_F 216_T 1.575 1.00
137_S 140_E 1.574 1.00
182_H 203_Q 1.549 1.00
264_N 319_T 1.523 1.00
380_L 383_Q 1.504 1.00
176_E 180_S 1.501 1.00
287_E 471_H 1.491 1.00
153_E 184_S 1.474 1.00
21_L 24_L 1.472 1.00
74_Q 155_D 1.467 1.00
202_V 205_A 1.462 1.00
26_L 206_G 1.454 1.00
117_M 129_L 1.451 1.00
12_R 57_K 1.449 1.00
269_S 324_R 1.442 1.00
180_S 183_Q 1.438 1.00
288_H 444_V 1.438 1.00
192_L 198_I 1.437 1.00
181_L 186_I 1.435 1.00
266_G 305_L 1.425 1.00
269_S 274_P 1.424 1.00
425_L 444_V 1.418 1.00
382_Q 386_D 1.408 1.00
120_A 129_L 1.405 0.99
276_L 279_L 1.402 0.99
47_R 52_E 1.398 0.99
379_K 383_Q 1.385 0.99
398_P 401_S 1.381 0.99
62_S 156_L 1.381 0.99
283_V 422_L 1.376 0.99
354_T 357_N 1.356 0.99
113_A 117_M 1.355 0.99
92_G 95_E 1.353 0.99
344_S 421_T 1.35 0.99
217_G 221_E 1.346 0.99
13_L 48_A 1.345 0.99
175_A 200_E 1.337 0.99
172_Q 176_E 1.337 0.99
13_L 44_A 1.323 0.99
136_L 144_T 1.321 0.99
48_A 60_R 1.32 0.99
123_F 147_C 1.314 0.99
267_V 277_N 1.312 0.99
92_G 96_D 1.29 0.99
14_S 57_K 1.288 0.99
260_R 454_Q 1.287 0.99
305_L 323_R 1.284 0.99
290_Q 466_P 1.27 0.99
320_L 325_R 1.269 0.99
259_P 285_P 1.241 0.98
289_W 456_L 1.234 0.98
48_A 55_L 1.232 0.98
30_D 203_Q 1.225 0.98
28_A 187_T 1.22 0.98
133_F 144_T 1.218 0.98
299_K 427_E 1.217 0.98
291_I 474_E 1.215 0.98
173_Q 176_E 1.213 0.98
79_V 159_L 1.211 0.98
281_W 302_L 1.2 0.98
267_V 325_R 1.2 0.98
276_L 305_L 1.187 0.98
427_E 460_H 1.185 0.98
32_W 216_T 1.181 0.98
33_A 198_I 1.172 0.98
221_E 224_Q 1.152 0.97
91_L 95_E 1.143 0.97
266_G 323_R 1.142 0.97
118_Q 121_Q 1.141 0.97
358_V 390_I 1.137 0.97
23_Q 212_T 1.135 0.97
359_I 377_Q 1.126 0.97
424_I 456_L 1.125 0.97
411_L 414_R 1.124 0.97
221_E 225_Q 1.121 0.97
32_W 189_V 1.12 0.96
223_L 226_A 1.114 0.96
43_S 47_R 1.108 0.96
319_T 324_R 1.107 0.96
13_L 53_L 1.098 0.96
16_T 19_L 1.096 0.96
77_K 80_S 1.096 0.96
91_L 94_G 1.088 0.96
383_Q 386_D 1.086 0.96
49_L 189_V 1.084 0.96
291_I 302_L 1.083 0.96
290_Q 459_S 1.081 0.95
11_F 48_A 1.077 0.95
112_D 116_C 1.074 0.95
267_V 274_P 1.074 0.95
419_H 453_T 1.073 0.95
337_H 421_T 1.072 0.95
385_L 390_I 1.069 0.95
459_S 465_A 1.066 0.95
444_V 455_L 1.066 0.95
423_L 455_L 1.064 0.95
11_F 55_L 1.061 0.95
190_L 201_F 1.061 0.95
389_G 439_L 1.059 0.95
300_S 426_D 1.057 0.95
125_I 128_L 1.055 0.95
157_L 186_I 1.054 0.95
213_L 216_T 1.053 0.95
339_G 420_P 1.051 0.94
376_R 379_K 1.045 0.94
437_R 461_H 1.043 0.94
89_D 134_K 1.043 0.94
45_L 208_L 1.041 0.94
31_S 188_L 1.039 0.94
425_L 455_L 1.034 0.94
281_W 289_W 1.032 0.94
222_L 226_A 1.026 0.94
15_D 44_A 1.026 0.94
291_I 303_L 1.025 0.93
159_L 178_L 1.025 0.93
446_V 449_S 1.022 0.93
423_L 453_T 1.016 0.93
288_H 448_I 1.015 0.93
226_A 229_A 1.013 0.93
443_F 446_V 1.01 0.93
295_N 460_H 1.007 0.93
24_L 213_L 1.005 0.93
258_E 284_N 1.001 0.92
139_G 295_N 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4finA20.92041000.223Contact Map0.726
2iw3A20.91021000.266Contact Map0.732
3bk7A10.93881000.274Contact Map0.674
1yqtA10.91431000.276Contact Map0.694
3j16B10.94291000.284Contact Map0.501
3ozxA20.92861000.285Contact Map0.716
3g5uA20.94291000.285Contact Map0.599
4f4cA10.9511000.287Contact Map0.636
3ux8A10.9511000.318Contact Map0.688
2vf7A30.9491000.42Contact Map0.658
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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