| UniProt: | Q6BEX0 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12518 | ||
| Length: | 500 (492) | ||
| Sequences: | 13738 | ||
| Seq/Len: | 27.92 |
| YTFR
Paralog alert: 0.93 [within 20: 0.27] - ratio of genomes with paralogs Cluster includes: ALSA ARAG GSIA LSRA MGLA MODF RBSA UUP XYLG YBHF YBIT YEJF YHES YJJK YPHE YTFR |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 36_E | 214_R | 4.487 | 1.00 | |
| 14_G | 27_N | 4.345 | 1.00 | |
| 269_N | 278_P | 4.339 | 1.00 | |
| 266_A | 282_E | 4.126 | 1.00 | |
| 26_D | 222_S | 3.995 | 1.00 | |
| 268_K | 316_T | 3.895 | 1.00 | |
| 287_E | 471_R | 3.698 | 1.00 | |
| 13_E | 65_T | 3.634 | 1.00 | |
| 303_A | 458_I | 3.477 | 1.00 | |
| 38_M | 216_T | 3.353 | 1.00 | |
| 65_T | 72_A | 3.316 | 1.00 | |
| 267_F | 270_Y | 3.3 | 1.00 | |
| 266_A | 318_L | 3.198 | 1.00 | |
| 11_R | 31_S | 3.197 | 1.00 | |
| 12_T | 15_L | 3.167 | 1.00 | |
| 316_T | 323_P | 3.044 | 1.00 | |
| 304_E | 310_K | 2.942 | 1.00 | |
| 23_K | 26_D | 2.937 | 1.00 | |
| 277_A | 479_K | 2.743 | 1.00 | |
| 289_V | 473_I | 2.698 | 1.00 | |
| 11_R | 67_W | 2.671 | 1.00 | |
| 39_A | 212_S | 2.648 | 1.00 | |
| 228_E | 231_E | 2.603 | 1.00 | |
| 125_R | 128_E | 2.582 | 1.00 | |
| 290_G | 469_A | 2.58 | 1.00 | |
| 336_G | 422_Q | 2.556 | 1.00 | |
| 386_I | 396_T | 2.539 | 1.00 | |
| 320_K | 422_Q | 2.535 | 1.00 | |
| 118_R | 121_E | 2.52 | 1.00 | |
| 69_E | 165_K | 2.502 | 1.00 | |
| 16_S | 27_N | 2.437 | 1.00 | |
| 267_F | 281_L | 2.419 | 1.00 | |
| 189_R | 210_Q | 2.391 | 1.00 | |
| 268_K | 318_L | 2.311 | 1.00 | |
| 52_I | 201_V | 2.289 | 1.00 | |
| 132_S | 194_R | 2.288 | 1.00 | |
| 269_N | 280_D | 2.253 | 1.00 | |
| 14_G | 29_D | 2.242 | 1.00 | |
| 18_F | 23_K | 2.227 | 1.00 | |
| 141_E | 145_R | 2.227 | 1.00 | |
| 263_P | 266_A | 2.209 | 1.00 | |
| 272_K | 313_D | 2.166 | 1.00 | |
| 272_K | 305_V | 2.163 | 1.00 | |
| 85_G | 165_K | 2.156 | 1.00 | |
| 459_S | 465_L | 2.146 | 1.00 | |
| 285_P | 422_Q | 2.102 | 1.00 | |
| 121_E | 125_R | 2.066 | 1.00 | |
| 305_V | 312_A | 2.057 | 1.00 | |
| 19_F | 59_Y | 2.05 | 1.00 | |
| 352_A | 401_E | 2.037 | 1.00 | |
| 302_T | 475_M | 2.008 | 1.00 | |
| 473_I | 483_E | 1.982 | 1.00 | |
| 271_G | 278_P | 1.977 | 1.00 | |
| 271_G | 314_S | 1.957 | 1.00 | |
| 125_R | 163_S | 1.957 | 1.00 | |
| 16_S | 23_K | 1.951 | 1.00 | |
| 303_A | 425_I | 1.92 | 1.00 | |
| 123_E | 140_R | 1.918 | 1.00 | |
| 12_T | 30_F | 1.914 | 1.00 | |
| 33_R | 36_E | 1.886 | 1.00 | |
| 262_K | 285_P | 1.853 | 1.00 | |
| 127_T | 131_A | 1.842 | 1.00 | |
| 77_N | 80_H | 1.84 | 1.00 | |
| 100_S | 103_D | 1.826 | 1.00 | |
| 75_P | 84_L | 1.82 | 1.00 | |
| 212_S | 229_T | 1.817 | 1.00 | |
| 447_T | 451_D | 1.803 | 1.00 | |
| 457_V | 468_Y | 1.779 | 1.00 | |
| 216_T | 223_F | 1.761 | 1.00 | |
| 12_T | 55_L | 1.749 | 1.00 | |
| 105_L | 161_D | 1.744 | 1.00 | |
| 284_R | 287_E | 1.728 | 1.00 | |
| 98_N | 144_N | 1.722 | 1.00 | |
| 384_R | 388_Q | 1.719 | 1.00 | |
| 268_K | 280_D | 1.713 | 1.00 | |
| 13_E | 67_W | 1.713 | 1.00 | |
| 281_L | 473_I | 1.707 | 1.00 | |
| 124_K | 128_E | 1.701 | 1.00 | |
| 385_F | 418_L | 1.692 | 1.00 | |
| 209_Y | 230_C | 1.691 | 1.00 | |
| 188_M | 198_L | 1.679 | 1.00 | |
| 290_G | 465_L | 1.673 | 1.00 | |
| 283_V | 289_V | 1.664 | 1.00 | |
| 87_G | 159_A | 1.637 | 1.00 | |
| 34_R | 165_K | 1.632 | 1.00 | |
| 16_S | 63_R | 1.628 | 1.00 | |
| 422_Q | 453_L | 1.61 | 1.00 | |
| 307_F | 425_I | 1.605 | 1.00 | |
| 72_A | 75_P | 1.605 | 1.00 | |
| 236_E | 239_K | 1.602 | 1.00 | |
| 356_R | 397_E | 1.585 | 1.00 | |
| 263_P | 282_E | 1.583 | 1.00 | |
| 142_P | 145_R | 1.568 | 1.00 | |
| 32_L | 166_V | 1.566 | 1.00 | |
| 283_V | 454_A | 1.56 | 1.00 | |
| 385_F | 414_S | 1.558 | 1.00 | |
| 473_I | 480_Q | 1.555 | 1.00 | |
| 482_A | 497_A | 1.555 | 1.00 | |
| 37_I | 188_M | 1.548 | 1.00 | |
| 386_I | 393_T | 1.541 | 1.00 | |
| 9_I | 197_S | 1.535 | 1.00 | |
| 388_Q | 447_T | 1.534 | 1.00 | |
| 138_D | 141_E | 1.534 | 1.00 | |
| 76_K | 80_H | 1.532 | 1.00 | |
| 225_G | 240_M | 1.528 | 1.00 | |
| 374_S | 377_E | 1.525 | 1.00 | |
| 132_S | 190_Q | 1.52 | 1.00 | |
| 400_I | 411_V | 1.512 | 1.00 | |
| 274_G | 277_A | 1.511 | 1.00 | |
| 14_G | 63_R | 1.508 | 1.00 | |
| 433_I | 441_I | 1.497 | 1.00 | |
| 227_R | 232_L | 1.497 | 1.00 | |
| 403_L | 411_V | 1.495 | 1.00 | |
| 165_K | 196_V | 1.493 | 1.00 | |
| 263_P | 284_R | 1.485 | 1.00 | |
| 267_F | 306_I | 1.483 | 1.00 | |
| 13_E | 31_S | 1.463 | 1.00 | |
| 129_L | 161_D | 1.46 | 1.00 | |
| 350_I | 361_L | 1.457 | 1.00 | |
| 89_V | 169_L | 1.454 | 1.00 | |
| 214_R | 226_C | 1.451 | 1.00 | |
| 13_E | 29_D | 1.444 | 1.00 | |
| 395_S | 398_Q | 1.437 | 1.00 | |
| 17_K | 54_A | 1.435 | 1.00 | |
| 270_Y | 312_A | 1.431 | 1.00 | |
| 285_P | 454_A | 1.412 | 1.00 | |
| 269_N | 314_S | 1.411 | 1.00 | |
| 15_L | 54_A | 1.41 | 1.00 | |
| 121_E | 124_K | 1.409 | 1.00 | |
| 268_K | 282_E | 1.409 | 1.00 | |
| 30_F | 216_T | 1.393 | 0.99 | |
| 190_Q | 194_R | 1.388 | 0.99 | |
| 182_E | 210_Q | 1.379 | 0.99 | |
| 381_I | 384_R | 1.373 | 0.99 | |
| 354_S | 357_E | 1.362 | 0.99 | |
| 56_T | 88_T | 1.353 | 0.99 | |
| 147_S | 150_M | 1.351 | 0.99 | |
| 202_T | 208_V | 1.345 | 0.99 | |
| 471_R | 483_E | 1.342 | 0.99 | |
| 192_R | 213_D | 1.339 | 0.99 | |
| 128_E | 132_S | 1.336 | 0.99 | |
| 383_E | 396_T | 1.336 | 0.99 | |
| 353_A | 357_E | 1.336 | 0.99 | |
| 237_L | 241_M | 1.328 | 0.99 | |
| 288_I | 445_I | 1.327 | 0.99 | |
| 186_D | 190_Q | 1.322 | 0.99 | |
| 58_V | 90_Y | 1.318 | 0.99 | |
| 32_L | 38_M | 1.314 | 0.99 | |
| 68_L | 166_V | 1.309 | 0.99 | |
| 17_K | 50_T | 1.307 | 0.99 | |
| 276_I | 279_F | 1.307 | 0.99 | |
| 355_V | 411_V | 1.303 | 0.99 | |
| 267_F | 317_A | 1.293 | 0.99 | |
| 340_C | 426_L | 1.286 | 0.99 | |
| 319_I | 324_Q | 1.285 | 0.99 | |
| 95_L | 143_L | 1.275 | 0.99 | |
| 283_V | 423_F | 1.272 | 0.99 | |
| 10_L | 68_L | 1.268 | 0.99 | |
| 398_Q | 402_F | 1.267 | 0.99 | |
| 272_K | 310_K | 1.265 | 0.99 | |
| 489_L | 493_A | 1.262 | 0.99 | |
| 360_I | 378_Q | 1.256 | 0.99 | |
| 67_W | 72_A | 1.253 | 0.99 | |
| 356_R | 396_T | 1.252 | 0.99 | |
| 287_E | 470_D | 1.238 | 0.98 | |
| 106_F | 126_A | 1.222 | 0.98 | |
| 380_E | 384_R | 1.217 | 0.98 | |
| 190_Q | 193_D | 1.212 | 0.98 | |
| 8_E | 33_R | 1.212 | 0.98 | |
| 54_A | 66_I | 1.203 | 0.98 | |
| 337_I | 423_F | 1.202 | 0.98 | |
| 18_F | 63_R | 1.201 | 0.98 | |
| 399_P | 402_F | 1.201 | 0.98 | |
| 383_E | 387_R | 1.199 | 0.98 | |
| 130_M | 139_V | 1.195 | 0.98 | |
| 426_L | 445_I | 1.195 | 0.98 | |
| 263_P | 285_P | 1.192 | 0.98 | |
| 486_L | 489_L | 1.185 | 0.98 | |
| 485_P | 488_E | 1.183 | 0.98 | |
| 102_A | 126_A | 1.178 | 0.98 | |
| 270_Y | 305_V | 1.177 | 0.98 | |
| 189_R | 192_R | 1.176 | 0.98 | |
| 358_N | 415_R | 1.167 | 0.97 | |
| 484_I | 497_A | 1.166 | 0.97 | |
| 227_R | 231_E | 1.16 | 0.97 | |
| 319_I | 423_F | 1.157 | 0.97 | |
| 52_I | 88_T | 1.156 | 0.97 | |
| 102_A | 123_E | 1.152 | 0.97 | |
| 133_Y | 157_C | 1.147 | 0.97 | |
| 445_I | 455_L | 1.134 | 0.97 | |
| 19_F | 50_T | 1.132 | 0.97 | |
| 291_L | 473_I | 1.128 | 0.97 | |
| 52_I | 168_I | 1.126 | 0.97 | |
| 71_Q | 80_H | 1.124 | 0.97 | |
| 68_L | 86_I | 1.121 | 0.97 | |
| 350_I | 353_A | 1.119 | 0.96 | |
| 182_E | 186_D | 1.117 | 0.96 | |
| 271_G | 277_A | 1.116 | 0.96 | |
| 106_F | 122_M | 1.113 | 0.96 | |
| 278_P | 479_K | 1.111 | 0.96 | |
| 16_S | 26_D | 1.108 | 0.96 | |
| 96_L | 107_I | 1.102 | 0.96 | |
| 25_L | 28_V | 1.102 | 0.96 | |
| 131_A | 136_S | 1.101 | 0.96 | |
| 15_L | 61_A | 1.101 | 0.96 | |
| 123_E | 127_T | 1.098 | 0.96 | |
| 264_V | 454_A | 1.097 | 0.96 | |
| 420_R | 451_D | 1.097 | 0.96 | |
| 289_V | 456_L | 1.095 | 0.96 | |
| 36_E | 213_D | 1.093 | 0.96 | |
| 212_S | 215_I | 1.093 | 0.96 | |
| 233_P | 236_E | 1.091 | 0.96 | |
| 127_T | 139_V | 1.09 | 0.96 | |
| 490_S | 493_A | 1.089 | 0.96 | |
| 377_E | 380_E | 1.088 | 0.96 | |
| 54_A | 61_A | 1.087 | 0.96 | |
| 97_P | 151_Q | 1.085 | 0.96 | |
| 143_L | 154_V | 1.082 | 0.96 | |
| 472_V | 489_L | 1.082 | 0.96 | |
| 27_N | 222_S | 1.079 | 0.95 | |
| 276_I | 305_V | 1.078 | 0.95 | |
| 151_Q | 343_D | 1.074 | 0.95 | |
| 338_G | 421_P | 1.063 | 0.95 | |
| 379_Q | 383_E | 1.062 | 0.95 | |
| 264_V | 320_K | 1.062 | 0.95 | |
| 146_F | 154_V | 1.052 | 0.95 | |
| 10_L | 55_L | 1.051 | 0.94 | |
| 12_T | 66_I | 1.05 | 0.94 | |
| 281_L | 302_T | 1.05 | 0.94 | |
| 87_G | 164_A | 1.049 | 0.94 | |
| 318_L | 323_P | 1.049 | 0.94 | |
| 292_A | 465_L | 1.037 | 0.94 | |
| 263_P | 318_L | 1.034 | 0.94 | |
| 238_V | 241_M | 1.034 | 0.94 | |
| 34_R | 197_S | 1.032 | 0.94 | |
| 19_F | 24_A | 1.025 | 0.93 | |
| 80_H | 83_Q | 1.023 | 0.93 | |
| 305_V | 317_A | 1.022 | 0.93 | |
| 163_S | 194_R | 1.02 | 0.93 | |
| 386_I | 391_I | 1.02 | 0.93 | |
| 349_I | 400_I | 1.019 | 0.93 | |
| 38_M | 226_C | 1.018 | 0.93 | |
| 39_A | 208_V | 1.018 | 0.93 | |
| 17_K | 59_Y | 1.014 | 0.93 | |
| 289_V | 483_E | 1.011 | 0.93 | |
| 448_L | 453_L | 1.009 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4finA | 2 | 0.912 | 100 | 0.205 | Contact Map | 0.751 |
| 3g5uA | 2 | 0.976 | 100 | 0.226 | Contact Map | 0.643 |
| 4f4cA | 1 | 0.966 | 100 | 0.23 | Contact Map | 0.71 |
| 1yqtA | 1 | 0.924 | 100 | 0.272 | Contact Map | 0.642 |
| 2iw3A | 2 | 0.892 | 100 | 0.278 | Contact Map | 0.719 |
| 3bk7A | 1 | 0.926 | 100 | 0.282 | Contact Map | 0.615 |
| 3ozxA | 2 | 0.902 | 100 | 0.284 | Contact Map | 0.666 |
| 3j16B | 1 | 0.936 | 100 | 0.3 | Contact Map | 0.465 |
| 3ux8A | 1 | 0.944 | 100 | 0.304 | Contact Map | 0.585 |
| 2vf7A | 3 | 0.97 | 100 | 0.413 | Contact Map | 0.555 |
Sequence Conservation (Image Generated using WebLogo v3)