| UniProt: | P33916 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12041 | ||
| Length: | 529 (513) | ||
| Sequences: | 13425 | ||
| Seq/Len: | 26.17 |
| YEJF
Paralog alert: 0.90 [within 20: 0.18] - ratio of genomes with paralogs Cluster includes: ALSA ARAG GSIA LSRA MGLA MODF RBSA UUP XYLG YBHF YBIT YEJF YHES YJJK YPHE YTFR |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 36_E | 226_R | 4.7 | 1.00 | |
| 280_Q | 304_N | 4.497 | 1.00 | |
| 10_N | 27_D | 4.472 | 1.00 | |
| 277_D | 308_T | 4.353 | 1.00 | |
| 26_N | 234_R | 4.201 | 1.00 | |
| 279_E | 341_S | 4.009 | 1.00 | |
| 9_E | 70_D | 3.841 | 1.00 | |
| 313_E | 495_Q | 3.752 | 1.00 | |
| 329_G | 482_I | 3.698 | 1.00 | |
| 70_D | 77_S | 3.612 | 1.00 | |
| 7_A | 31_Q | 3.501 | 1.00 | |
| 278_V | 281_L | 3.485 | 1.00 | |
| 38_L | 228_A | 3.469 | 1.00 | |
| 8_I | 11_L | 3.251 | 1.00 | |
| 277_D | 343_I | 3.243 | 1.00 | |
| 330_L | 336_I | 3.1 | 1.00 | |
| 23_T | 26_N | 3.093 | 1.00 | |
| 341_S | 348_P | 3.014 | 1.00 | |
| 303_K | 503_E | 2.865 | 1.00 | |
| 315_L | 497_I | 2.853 | 1.00 | |
| 39_A | 224_A | 2.781 | 1.00 | |
| 240_Y | 243_T | 2.666 | 1.00 | |
| 12_S | 27_D | 2.646 | 1.00 | |
| 7_A | 72_R | 2.644 | 1.00 | |
| 316_G | 493_C | 2.634 | 1.00 | |
| 278_V | 307_F | 2.622 | 1.00 | |
| 345_D | 445_S | 2.617 | 1.00 | |
| 409_M | 419_R | 2.612 | 1.00 | |
| 16_R | 21_V | 2.596 | 1.00 | |
| 74_H | 176_E | 2.57 | 1.00 | |
| 133_E | 136_N | 2.55 | 1.00 | |
| 363_R | 445_S | 2.527 | 1.00 | |
| 126_R | 129_A | 2.488 | 1.00 | |
| 131_R | 151_T | 2.461 | 1.00 | |
| 280_Q | 306_S | 2.382 | 1.00 | |
| 279_E | 343_I | 2.366 | 1.00 | |
| 10_N | 29_S | 2.349 | 1.00 | |
| 52_A | 213_I | 2.337 | 1.00 | |
| 200_R | 222_K | 2.333 | 1.00 | |
| 283_V | 331_A | 2.308 | 1.00 | |
| 129_A | 133_E | 2.3 | 1.00 | |
| 140_R | 205_E | 2.279 | 1.00 | |
| 14_G | 23_T | 2.264 | 1.00 | |
| 483_S | 489_V | 2.21 | 1.00 | |
| 331_A | 337_N | 2.201 | 1.00 | |
| 311_A | 445_S | 2.172 | 1.00 | |
| 152_D | 156_Q | 2.167 | 1.00 | |
| 329_G | 448_I | 2.129 | 1.00 | |
| 15_F | 59_L | 2.11 | 1.00 | |
| 282_Q | 304_N | 2.102 | 1.00 | |
| 378_R | 424_A | 2.078 | 1.00 | |
| 283_V | 338_S | 2.051 | 1.00 | |
| 93_K | 176_E | 2.035 | 1.00 | |
| 328_T | 499_L | 2.034 | 1.00 | |
| 224_A | 241_A | 2.024 | 1.00 | |
| 8_I | 30_L | 1.996 | 1.00 | |
| 133_E | 174_R | 1.992 | 1.00 | |
| 274_T | 277_D | 1.974 | 1.00 | |
| 33_E | 36_E | 1.956 | 1.00 | |
| 12_S | 23_T | 1.937 | 1.00 | |
| 135_L | 139_D | 1.912 | 1.00 | |
| 407_A | 411_E | 1.908 | 1.00 | |
| 300_V | 303_K | 1.903 | 1.00 | |
| 282_Q | 339_Q | 1.868 | 1.00 | |
| 201_E | 205_E | 1.865 | 1.00 | |
| 481_F | 492_L | 1.845 | 1.00 | |
| 132_G | 136_N | 1.841 | 1.00 | |
| 228_A | 235_C | 1.837 | 1.00 | |
| 9_E | 72_R | 1.83 | 1.00 | |
| 310_R | 313_E | 1.825 | 1.00 | |
| 82_S | 85_T | 1.825 | 1.00 | |
| 307_F | 497_I | 1.8 | 1.00 | |
| 273_S | 311_A | 1.798 | 1.00 | |
| 221_R | 242_A | 1.785 | 1.00 | |
| 470_S | 474_K | 1.778 | 1.00 | |
| 316_G | 489_V | 1.771 | 1.00 | |
| 80_H | 92_N | 1.767 | 1.00 | |
| 509_P | 512_R | 1.76 | 1.00 | |
| 199_L | 210_M | 1.759 | 1.00 | |
| 77_S | 80_H | 1.755 | 1.00 | |
| 95_A | 170_A | 1.755 | 1.00 | |
| 397_S | 400_Q | 1.721 | 1.00 | |
| 110_T | 113_K | 1.72 | 1.00 | |
| 309_L | 315_L | 1.715 | 1.00 | |
| 32_I | 177_L | 1.708 | 1.00 | |
| 37_T | 199_L | 1.705 | 1.00 | |
| 140_R | 201_E | 1.705 | 1.00 | |
| 445_S | 477_L | 1.705 | 1.00 | |
| 34_A | 176_E | 1.69 | 1.00 | |
| 279_E | 306_S | 1.689 | 1.00 | |
| 411_E | 470_S | 1.676 | 1.00 | |
| 8_I | 55_I | 1.667 | 1.00 | |
| 408_V | 441_I | 1.659 | 1.00 | |
| 426_F | 434_I | 1.65 | 1.00 | |
| 5_L | 209_G | 1.637 | 1.00 | |
| 456_L | 464_I | 1.636 | 1.00 | |
| 12_S | 68_S | 1.634 | 1.00 | |
| 408_V | 437_A | 1.632 | 1.00 | |
| 176_E | 208_M | 1.623 | 1.00 | |
| 97_I | 180_A | 1.616 | 1.00 | |
| 409_M | 416_P | 1.578 | 1.00 | |
| 129_A | 132_G | 1.572 | 1.00 | |
| 309_L | 478_A | 1.566 | 1.00 | |
| 10_N | 68_S | 1.56 | 1.00 | |
| 30_L | 228_A | 1.554 | 1.00 | |
| 239_N | 244_L | 1.553 | 1.00 | |
| 226_R | 238_Q | 1.552 | 1.00 | |
| 280_Q | 339_Q | 1.546 | 1.00 | |
| 278_V | 332_L | 1.545 | 1.00 | |
| 81_A | 85_T | 1.543 | 1.00 | |
| 423_P | 434_I | 1.535 | 1.00 | |
| 497_I | 507_Q | 1.526 | 1.00 | |
| 497_I | 504_V | 1.526 | 1.00 | |
| 153_Y | 156_Q | 1.512 | 1.00 | |
| 333_L | 448_I | 1.512 | 1.00 | |
| 200_R | 203_Q | 1.509 | 1.00 | |
| 311_A | 478_A | 1.489 | 1.00 | |
| 115_L | 172_L | 1.489 | 1.00 | |
| 32_I | 38_L | 1.479 | 1.00 | |
| 9_E | 31_Q | 1.476 | 1.00 | |
| 193_A | 222_K | 1.47 | 1.00 | |
| 11_L | 54_S | 1.462 | 1.00 | |
| 309_L | 446_L | 1.456 | 1.00 | |
| 380_N | 383_Q | 1.447 | 1.00 | |
| 279_E | 308_T | 1.447 | 1.00 | |
| 281_L | 337_N | 1.444 | 1.00 | |
| 73_F | 177_L | 1.443 | 1.00 | |
| 386_E | 401_R | 1.442 | 1.00 | |
| 376_N | 387_E | 1.442 | 1.00 | |
| 274_T | 308_T | 1.439 | 1.00 | |
| 137_C | 172_L | 1.437 | 1.00 | |
| 9_E | 29_S | 1.435 | 1.00 | |
| 367_V | 449_L | 1.434 | 1.00 | |
| 382_L | 420_H | 1.43 | 1.00 | |
| 284_A | 338_S | 1.42 | 1.00 | |
| 158_S | 161_E | 1.419 | 1.00 | |
| 13_V | 54_S | 1.408 | 1.00 | |
| 136_N | 140_R | 1.408 | 1.00 | |
| 274_T | 310_R | 1.406 | 0.99 | |
| 314_T | 468_L | 1.403 | 0.99 | |
| 379_L | 383_Q | 1.397 | 0.99 | |
| 108_L | 155_H | 1.379 | 0.99 | |
| 406_I | 410_H | 1.364 | 0.99 | |
| 418_T | 421_R | 1.361 | 0.99 | |
| 105_L | 154_P | 1.355 | 0.99 | |
| 203_Q | 225_H | 1.35 | 0.99 | |
| 149_R | 152_D | 1.341 | 0.99 | |
| 201_E | 204_G | 1.336 | 0.99 | |
| 302_V | 305_I | 1.335 | 0.99 | |
| 6_L | 73_F | 1.331 | 0.99 | |
| 58_L | 98_F | 1.327 | 0.99 | |
| 344_F | 446_L | 1.327 | 0.99 | |
| 381_V | 434_I | 1.324 | 0.99 | |
| 56_L | 96_M | 1.324 | 0.99 | |
| 13_V | 50_V | 1.316 | 0.99 | |
| 112_E | 131_R | 1.314 | 0.99 | |
| 214_T | 220_V | 1.31 | 0.99 | |
| 344_F | 349_L | 1.307 | 0.99 | |
| 495_Q | 507_Q | 1.305 | 0.99 | |
| 139_D | 147_A | 1.305 | 0.99 | |
| 278_V | 342_I | 1.295 | 0.99 | |
| 406_I | 419_R | 1.294 | 0.99 | |
| 135_L | 150_L | 1.293 | 0.99 | |
| 131_R | 135_L | 1.285 | 0.99 | |
| 237_E | 255_K | 1.268 | 0.99 | |
| 27_D | 234_R | 1.262 | 0.99 | |
| 313_E | 494_H | 1.257 | 0.99 | |
| 403_Q | 407_A | 1.25 | 0.99 | |
| 404_Q | 407_A | 1.247 | 0.99 | |
| 281_L | 331_A | 1.24 | 0.98 | |
| 283_V | 336_I | 1.231 | 0.98 | |
| 315_L | 480_L | 1.229 | 0.98 | |
| 72_R | 77_S | 1.229 | 0.98 | |
| 304_N | 503_E | 1.216 | 0.98 | |
| 364_I | 446_L | 1.208 | 0.98 | |
| 239_N | 243_T | 1.207 | 0.98 | |
| 421_R | 425_E | 1.205 | 0.98 | |
| 14_G | 68_S | 1.203 | 0.98 | |
| 284_A | 300_V | 1.191 | 0.98 | |
| 317_L | 497_I | 1.19 | 0.98 | |
| 243_T | 247_S | 1.185 | 0.98 | |
| 449_L | 468_L | 1.183 | 0.98 | |
| 52_A | 96_M | 1.183 | 0.98 | |
| 4_T | 33_E | 1.181 | 0.98 | |
| 138_L | 150_L | 1.17 | 0.97 | |
| 38_L | 238_Q | 1.161 | 0.97 | |
| 384_I | 438_R | 1.161 | 0.97 | |
| 508_G | 513_V | 1.146 | 0.97 | |
| 274_T | 311_A | 1.146 | 0.97 | |
| 382_L | 419_R | 1.146 | 0.97 | |
| 15_F | 50_V | 1.144 | 0.97 | |
| 8_I | 71_I | 1.141 | 0.97 | |
| 307_F | 328_T | 1.14 | 0.97 | |
| 52_A | 179_I | 1.133 | 0.97 | |
| 12_S | 26_N | 1.126 | 0.97 | |
| 85_T | 88_G | 1.121 | 0.97 | |
| 400_Q | 403_Q | 1.115 | 0.96 | |
| 451_E | 484_H | 1.114 | 0.96 | |
| 318_V | 489_V | 1.114 | 0.96 | |
| 34_A | 209_G | 1.106 | 0.96 | |
| 14_G | 67_L | 1.106 | 0.96 | |
| 409_M | 414_L | 1.101 | 0.96 | |
| 422_Y | 425_E | 1.098 | 0.96 | |
| 251_P | 254_Q | 1.09 | 0.96 | |
| 76_E | 85_T | 1.088 | 0.96 | |
| 141_V | 168_A | 1.087 | 0.96 | |
| 282_Q | 303_K | 1.084 | 0.96 | |
| 343_I | 348_P | 1.08 | 0.95 | |
| 54_S | 71_I | 1.078 | 0.95 | |
| 489_V | 493_C | 1.076 | 0.95 | |
| 302_V | 331_A | 1.075 | 0.95 | |
| 224_A | 227_V | 1.074 | 0.95 | |
| 375_L | 423_P | 1.07 | 0.95 | |
| 6_L | 55_I | 1.065 | 0.95 | |
| 157_L | 165_V | 1.065 | 0.95 | |
| 15_F | 24_V | 1.061 | 0.95 | |
| 36_E | 225_H | 1.053 | 0.95 | |
| 25_V | 28_V | 1.048 | 0.94 | |
| 275_L | 478_A | 1.047 | 0.94 | |
| 499_L | 504_V | 1.043 | 0.94 | |
| 275_L | 345_D | 1.04 | 0.94 | |
| 443_K | 477_L | 1.039 | 0.94 | |
| 136_N | 139_D | 1.038 | 0.94 | |
| 407_A | 410_H | 1.033 | 0.94 | |
| 38_L | 226_R | 1.033 | 0.94 | |
| 116_Y | 130_A | 1.032 | 0.94 | |
| 325_K | 451_E | 1.031 | 0.94 | |
| 376_N | 379_L | 1.031 | 0.94 | |
| 402_E | 406_I | 1.024 | 0.93 | |
| 317_L | 328_T | 1.022 | 0.93 | |
| 508_G | 512_R | 1.02 | 0.93 | |
| 73_F | 94_I | 1.013 | 0.93 | |
| 162_R | 370_D | 1.013 | 0.93 | |
| 95_A | 175_P | 1.01 | 0.93 | |
| 28_V | 235_C | 1.003 | 0.93 | |
| 435_A | 438_R | 1.002 | 0.92 | |
| 178_L | 208_M | 1.001 | 0.92 | |
| 334_R | 357_L | 1.001 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4finA | 2 | 0.8733 | 100 | 0.2 | Contact Map | 0.759 |
| 3g5uA | 2 | 0.9225 | 100 | 0.211 | Contact Map | 0.672 |
| 4f4cA | 1 | 0.9225 | 100 | 0.216 | Contact Map | 0.742 |
| 2iw3A | 2 | 0.8412 | 100 | 0.274 | Contact Map | 0.751 |
| 1yqtA | 1 | 0.8828 | 100 | 0.277 | Contact Map | 0.658 |
| 3bk7A | 1 | 0.8828 | 100 | 0.283 | Contact Map | 0.633 |
| 3ozxA | 2 | 0.8639 | 100 | 0.29 | Contact Map | 0.671 |
| 3j16B | 1 | 0.8941 | 100 | 0.294 | Contact Map | 0.44 |
| 3ux8A | 1 | 0.9017 | 100 | 0.301 | Contact Map | 0.62 |
| 2vf7A | 3 | 0.9282 | 100 | 0.396 | Contact Map | 0.575 |
Sequence Conservation (Image Generated using WebLogo v3)