| UniProt: | P63389 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12903 | ||
| Length: | 637 (626) | ||
| Sequences: | 5790 | ||
| Seq/Len: | 9.25 |
| YHES
Paralog alert: 0.90 [within 20: 0.06] - ratio of genomes with paralogs Cluster includes: ALSA ARAG GSIA LSRA MGLA MODF RBSA UUP XYLG YBHF YBIT YEJF YHES YJJK YPHE YTFR |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 210_D | 232_S | 4.751 | 1.00 | |
| 317_K | 330_S | 4.662 | 1.00 | |
| 577_Q | 605_Q | 4.176 | 1.00 | |
| 97_Q | 109_A | 4.032 | 1.00 | |
| 6_S | 19_N | 3.883 | 1.00 | |
| 315_M | 318_V | 3.836 | 1.00 | |
| 316_E | 368_E | 3.51 | 1.00 | |
| 391_D | 429_R | 3.418 | 1.00 | |
| 563_E | 619_A | 3.312 | 1.00 | |
| 4_F | 7_L | 3.274 | 1.00 | |
| 121_D | 124_S | 3.196 | 1.00 | |
| 320_A | 365_V | 3.147 | 1.00 | |
| 335_L | 341_I | 3.02 | 1.00 | |
| 317_K | 332_K | 3.02 | 1.00 | |
| 260_Q | 264_D | 2.895 | 1.00 | |
| 392_E | 400_R | 2.829 | 1.00 | |
| 570_E | 612_G | 2.622 | 1.00 | |
| 355_I | 483_V | 2.574 | 1.00 | |
| 608_S | 612_G | 2.556 | 1.00 | |
| 44_L | 202_I | 2.551 | 1.00 | |
| 491_R | 513_E | 2.53 | 1.00 | |
| 339_S | 496_D | 2.514 | 1.00 | |
| 94_L | 113_I | 2.423 | 1.00 | |
| 321_G | 365_V | 2.403 | 1.00 | |
| 320_A | 357_L | 2.401 | 1.00 | |
| 311_P | 370_G | 2.401 | 1.00 | |
| 117_L | 122_A | 2.384 | 1.00 | |
| 319_S | 366_S | 2.377 | 1.00 | |
| 315_M | 333_L | 2.33 | 1.00 | |
| 359_A | 453_L | 2.325 | 1.00 | |
| 397_H | 443_L | 2.324 | 1.00 | |
| 389_R | 392_E | 2.303 | 1.00 | |
| 15_V | 18_D | 2.286 | 1.00 | |
| 89_R | 93_Q | 2.283 | 1.00 | |
| 263_I | 280_I | 2.282 | 1.00 | |
| 567_L | 616_C | 2.266 | 1.00 | |
| 326_I | 329_D | 2.25 | 1.00 | |
| 317_K | 366_S | 2.164 | 1.00 | |
| 233_S | 237_Q | 2.118 | 1.00 | |
| 428_T | 439_L | 2.111 | 1.00 | |
| 581_A | 602_C | 2.102 | 1.00 | |
| 28_Q | 215_K | 2.08 | 1.00 | |
| 90_E | 116_K | 2.066 | 1.00 | |
| 9_I | 51_I | 2.056 | 1.00 | |
| 128_R | 167_R | 2.049 | 1.00 | |
| 7_L | 53_A | 2.017 | 1.00 | |
| 4_F | 22_A | 2.016 | 1.00 | |
| 578_L | 609_A | 2.002 | 1.00 | |
| 341_I | 498_Y | 1.981 | 1.00 | |
| 357_L | 364_P | 1.977 | 1.00 | |
| 511_D | 514_D | 1.97 | 1.00 | |
| 215_K | 226_E | 1.97 | 1.00 | |
| 574_L | 616_C | 1.965 | 1.00 | |
| 78_Q | 148_S | 1.96 | 1.00 | |
| 8_Q | 55_G | 1.954 | 1.00 | |
| 213_V | 216_I | 1.95 | 1.00 | |
| 5_S | 57_S | 1.938 | 1.00 | |
| 249_Y | 253_Q | 1.931 | 1.00 | |
| 145_R | 149_D | 1.922 | 1.00 | |
| 610_K | 614_E | 1.899 | 1.00 | |
| 31_G | 209_L | 1.866 | 1.00 | |
| 357_L | 369_I | 1.864 | 1.00 | |
| 18_D | 223_S | 1.863 | 1.00 | |
| 189_E | 211_P | 1.857 | 1.00 | |
| 356_K | 361_E | 1.855 | 1.00 | |
| 318_V | 364_P | 1.842 | 1.00 | |
| 570_E | 616_C | 1.84 | 1.00 | |
| 67_A | 163_A | 1.837 | 1.00 | |
| 46_L | 58_Y | 1.833 | 1.00 | |
| 315_M | 369_I | 1.801 | 1.00 | |
| 267_R | 280_I | 1.8 | 1.00 | |
| 225_F | 241_R | 1.794 | 1.00 | |
| 255_R | 258_H | 1.788 | 1.00 | |
| 598_E | 601_A | 1.772 | 1.00 | |
| 426_E | 430_R | 1.765 | 1.00 | |
| 314_K | 370_G | 1.763 | 1.00 | |
| 328_L | 331_I | 1.763 | 1.00 | |
| 314_K | 334_N | 1.76 | 1.00 | |
| 240_T | 243_A | 1.757 | 1.00 | |
| 342_G | 494_T | 1.755 | 1.00 | |
| 584_K | 598_E | 1.736 | 1.00 | |
| 233_S | 236_V | 1.728 | 1.00 | |
| 4_F | 47_L | 1.728 | 1.00 | |
| 571_M | 613_L | 1.724 | 1.00 | |
| 577_Q | 580_Q | 1.723 | 1.00 | |
| 393_S | 396_Q | 1.72 | 1.00 | |
| 473_L | 480_L | 1.7 | 1.00 | |
| 146_P | 149_D | 1.7 | 1.00 | |
| 423_K | 426_E | 1.699 | 1.00 | |
| 378_G | 449_P | 1.698 | 1.00 | |
| 581_A | 609_A | 1.689 | 1.00 | |
| 261_S | 264_D | 1.685 | 1.00 | |
| 574_L | 609_A | 1.684 | 1.00 | |
| 31_G | 216_I | 1.679 | 1.00 | |
| 566_R | 570_E | 1.676 | 1.00 | |
| 77_P | 148_S | 1.668 | 1.00 | |
| 395_I | 410_L | 1.666 | 1.00 | |
| 236_V | 240_T | 1.658 | 1.00 | |
| 97_Q | 100_D | 1.646 | 1.00 | |
| 116_K | 120_I | 1.642 | 1.00 | |
| 193_K | 211_P | 1.641 | 1.00 | |
| 313_L | 451_L | 1.633 | 1.00 | |
| 561_R | 565_A | 1.629 | 1.00 | |
| 449_P | 476_F | 1.619 | 1.00 | |
| 320_A | 362_L | 1.604 | 1.00 | |
| 582_E | 610_K | 1.601 | 1.00 | |
| 617_E | 621_L | 1.593 | 1.00 | |
| 217_I | 224_M | 1.593 | 1.00 | |
| 280_I | 284_E | 1.591 | 1.00 | |
| 167_R | 196_Q | 1.582 | 1.00 | |
| 578_L | 606_Q | 1.571 | 1.00 | |
| 9_I | 46_L | 1.564 | 1.00 | |
| 582_E | 606_Q | 1.557 | 1.00 | |
| 6_S | 21_T | 1.55 | 1.00 | |
| 564_I | 623_A | 1.547 | 1.00 | |
| 246_Q | 250_E | 1.545 | 1.00 | |
| 114_H | 118_D | 1.536 | 1.00 | |
| 316_E | 332_K | 1.533 | 1.00 | |
| 604_Q | 608_S | 1.529 | 1.00 | |
| 601_A | 605_Q | 1.528 | 1.00 | |
| 572_E | 576_A | 1.513 | 1.00 | |
| 594_S | 598_E | 1.513 | 1.00 | |
| 453_L | 481_V | 1.504 | 1.00 | |
| 319_S | 330_S | 1.503 | 1.00 | |
| 17_L | 20_A | 1.487 | 1.00 | |
| 8_Q | 19_N | 1.48 | 1.00 | |
| 392_E | 397_H | 1.472 | 1.00 | |
| 121_D | 128_R | 1.464 | 1.00 | |
| 562_K | 565_A | 1.463 | 1.00 | |
| 263_I | 283_L | 1.459 | 1.00 | |
| 99_H | 102_N | 1.452 | 1.00 | |
| 333_L | 498_Y | 1.45 | 1.00 | |
| 612_G | 615_E | 1.449 | 1.00 | |
| 580_Q | 584_K | 1.447 | 1.00 | |
| 253_Q | 256_V | 1.445 | 1.00 | |
| 576_A | 580_Q | 1.438 | 1.00 | |
| 41_S | 45_A | 1.431 | 0.99 | |
| 50_E | 70_N | 1.43 | 0.99 | |
| 342_G | 490_L | 1.429 | 0.99 | |
| 316_E | 370_G | 1.428 | 0.99 | |
| 47_L | 200_I | 1.423 | 0.99 | |
| 69_V | 163_A | 1.422 | 0.99 | |
| 190_K | 194_S | 1.417 | 0.99 | |
| 142_Q | 145_R | 1.415 | 0.99 | |
| 24_I | 170_L | 1.41 | 0.99 | |
| 570_E | 573_K | 1.404 | 0.99 | |
| 243_A | 247_A | 1.401 | 0.99 | |
| 94_L | 116_K | 1.401 | 0.99 | |
| 65_Q | 169_D | 1.401 | 0.99 | |
| 269_K | 272_K | 1.4 | 0.99 | |
| 376_K | 447_Q | 1.396 | 0.99 | |
| 60_F | 66_L | 1.394 | 0.99 | |
| 391_D | 427_E | 1.385 | 0.99 | |
| 277_Q | 280_I | 1.384 | 0.99 | |
| 45_A | 50_E | 1.383 | 0.99 | |
| 150_F | 158_L | 1.38 | 0.99 | |
| 93_Q | 97_Q | 1.379 | 0.99 | |
| 256_V | 283_L | 1.376 | 0.99 | |
| 67_A | 168_S | 1.371 | 0.99 | |
| 597_A | 601_A | 1.357 | 0.99 | |
| 6_S | 55_G | 1.351 | 0.99 | |
| 318_V | 369_I | 1.342 | 0.99 | |
| 329_D | 504_K | 1.342 | 0.99 | |
| 163_A | 171_L | 1.341 | 0.99 | |
| 578_L | 613_L | 1.341 | 0.99 | |
| 270_A | 273_A | 1.34 | 0.99 | |
| 5_S | 21_T | 1.34 | 0.99 | |
| 32_L | 219_I | 1.338 | 0.99 | |
| 352_S | 356_K | 1.33 | 0.99 | |
| 482_V | 494_T | 1.322 | 0.99 | |
| 46_L | 53_A | 1.318 | 0.99 | |
| 339_S | 495_D | 1.313 | 0.99 | |
| 230_N | 233_S | 1.311 | 0.99 | |
| 614_E | 618_M | 1.307 | 0.99 | |
| 496_D | 507_P | 1.305 | 0.99 | |
| 573_K | 577_Q | 1.296 | 0.99 | |
| 190_K | 193_K | 1.295 | 0.99 | |
| 577_Q | 609_A | 1.29 | 0.99 | |
| 22_A | 217_I | 1.282 | 0.99 | |
| 319_S | 329_D | 1.277 | 0.99 | |
| 578_L | 610_K | 1.276 | 0.99 | |
| 315_M | 358_L | 1.276 | 0.99 | |
| 218_H | 238_R | 1.274 | 0.99 | |
| 571_M | 575_N | 1.272 | 0.98 | |
| 96_A | 100_D | 1.271 | 0.98 | |
| 61_P | 64_W | 1.27 | 0.98 | |
| 9_I | 42_T | 1.27 | 0.98 | |
| 321_G | 326_I | 1.268 | 0.98 | |
| 615_E | 618_M | 1.267 | 0.98 | |
| 147_V | 158_L | 1.26 | 0.98 | |
| 260_Q | 288_L | 1.259 | 0.98 | |
| 244_Q | 248_M | 1.258 | 0.98 | |
| 24_I | 30_V | 1.256 | 0.98 | |
| 569_K | 572_E | 1.255 | 0.98 | |
| 600_T | 604_Q | 1.25 | 0.98 | |
| 356_K | 362_L | 1.243 | 0.98 | |
| 575_N | 613_L | 1.241 | 0.98 | |
| 155_R | 383_H | 1.241 | 0.98 | |
| 619_A | 623_A | 1.241 | 0.98 | |
| 574_L | 613_L | 1.24 | 0.98 | |
| 269_K | 273_A | 1.24 | 0.98 | |
| 112_T | 116_K | 1.236 | 0.98 | |
| 90_E | 93_Q | 1.232 | 0.98 | |
| 605_Q | 608_S | 1.225 | 0.98 | |
| 615_E | 619_A | 1.225 | 0.98 | |
| 395_I | 424_V | 1.214 | 0.98 | |
| 29_K | 214_D | 1.213 | 0.98 | |
| 579_A | 583_E | 1.213 | 0.98 | |
| 584_K | 602_C | 1.213 | 0.98 | |
| 84_V | 133_L | 1.213 | 0.98 | |
| 394_P | 439_L | 1.211 | 0.98 | |
| 218_H | 234_F | 1.206 | 0.98 | |
| 594_S | 597_A | 1.206 | 0.98 | |
| 96_A | 99_H | 1.192 | 0.97 | |
| 310_N | 336_V | 1.189 | 0.97 | |
| 605_Q | 609_A | 1.186 | 0.97 | |
| 558_Q | 562_K | 1.186 | 0.97 | |
| 278_S | 281_K | 1.185 | 0.97 | |
| 335_L | 479_A | 1.184 | 0.97 | |
| 217_I | 226_E | 1.184 | 0.97 | |
| 318_V | 357_L | 1.18 | 0.97 | |
| 28_Q | 214_D | 1.178 | 0.97 | |
| 338_G | 479_A | 1.177 | 0.97 | |
| 254_E | 257_A | 1.172 | 0.97 | |
| 584_K | 587_D | 1.172 | 0.97 | |
| 48_K | 68_W | 1.17 | 0.97 | |
| 78_Q | 146_P | 1.17 | 0.97 | |
| 606_Q | 610_K | 1.169 | 0.97 | |
| 93_Q | 96_A | 1.169 | 0.97 | |
| 124_S | 128_R | 1.168 | 0.97 | |
| 609_A | 612_G | 1.161 | 0.97 | |
| 79_A | 82_E | 1.157 | 0.97 | |
| 219_I | 224_M | 1.155 | 0.97 | |
| 514_D | 517_Q | 1.152 | 0.97 | |
| 574_L | 578_L | 1.151 | 0.97 | |
| 562_K | 566_R | 1.15 | 0.97 | |
| 390_A | 429_R | 1.15 | 0.97 | |
| 607_A | 611_S | 1.149 | 0.97 | |
| 5_S | 59_T | 1.145 | 0.97 | |
| 95_E | 99_H | 1.144 | 0.97 | |
| 427_E | 430_R | 1.135 | 0.96 | |
| 612_G | 616_C | 1.135 | 0.96 | |
| 364_P | 369_I | 1.134 | 0.96 | |
| 92_R | 96_A | 1.133 | 0.96 | |
| 189_E | 487_R | 1.133 | 0.96 | |
| 239_A | 243_A | 1.129 | 0.96 | |
| 227_Y | 241_R | 1.128 | 0.96 | |
| 482_V | 493_T | 1.124 | 0.96 | |
| 90_E | 120_I | 1.122 | 0.96 | |
| 397_H | 428_T | 1.117 | 0.96 | |
| 309_P | 372_A | 1.116 | 0.96 | |
| 490_L | 494_T | 1.113 | 0.96 | |
| 125_I | 165_I | 1.113 | 0.96 | |
| 326_I | 503_R | 1.112 | 0.96 | |
| 482_V | 490_L | 1.111 | 0.96 | |
| 341_I | 481_V | 1.107 | 0.96 | |
| 118_D | 123_W | 1.106 | 0.96 | |
| 396_Q | 399_A | 1.099 | 0.95 | |
| 346_R | 349_A | 1.097 | 0.95 | |
| 259_L | 282_M | 1.094 | 0.95 | |
| 621_L | 625_E | 1.093 | 0.95 | |
| 614_E | 617_E | 1.092 | 0.95 | |
| 262_Y | 266_F | 1.088 | 0.95 | |
| 170_L | 198_T | 1.086 | 0.95 | |
| 603_L | 607_A | 1.084 | 0.95 | |
| 618_M | 621_L | 1.084 | 0.95 | |
| 611_S | 615_E | 1.083 | 0.95 | |
| 618_M | 622_E | 1.079 | 0.95 | |
| 237_Q | 240_T | 1.075 | 0.95 | |
| 262_Y | 279_R | 1.074 | 0.95 | |
| 572_E | 575_N | 1.073 | 0.94 | |
| 272_K | 275_Q | 1.073 | 0.94 | |
| 619_A | 622_E | 1.073 | 0.94 | |
| 229_G | 233_S | 1.071 | 0.94 | |
| 585_L | 599_L | 1.069 | 0.94 | |
| 343_L | 481_V | 1.069 | 0.94 | |
| 500_V | 505_V | 1.066 | 0.94 | |
| 8_Q | 15_V | 1.063 | 0.94 | |
| 392_E | 396_Q | 1.06 | 0.94 | |
| 580_Q | 583_E | 1.058 | 0.94 | |
| 565_A | 569_K | 1.056 | 0.94 | |
| 351_K | 456_E | 1.052 | 0.94 | |
| 255_R | 259_L | 1.05 | 0.94 | |
| 319_S | 326_I | 1.049 | 0.94 | |
| 304_A | 477_E | 1.048 | 0.94 | |
| 30_V | 217_I | 1.045 | 0.93 | |
| 313_L | 371_L | 1.044 | 0.93 | |
| 262_Y | 275_Q | 1.044 | 0.93 | |
| 312_L | 479_A | 1.042 | 0.93 | |
| 240_T | 244_Q | 1.04 | 0.93 | |
| 264_D | 267_R | 1.037 | 0.93 | |
| 474_I | 492_S | 1.037 | 0.93 | |
| 578_L | 582_E | 1.035 | 0.93 | |
| 249_Y | 252_Q | 1.034 | 0.93 | |
| 473_L | 493_T | 1.034 | 0.93 | |
| 4_F | 58_Y | 1.031 | 0.93 | |
| 311_P | 314_K | 1.031 | 0.93 | |
| 31_G | 213_V | 1.029 | 0.93 | |
| 109_A | 112_T | 1.024 | 0.92 | |
| 548_R | 551_A | 1.02 | 0.92 | |
| 85_I | 129_A | 1.02 | 0.92 | |
| 611_S | 614_E | 1.02 | 0.92 | |
| 482_V | 489_L | 1.017 | 0.92 | |
| 394_P | 428_T | 1.015 | 0.92 | |
| 607_A | 610_K | 1.012 | 0.92 | |
| 242_L | 246_Q | 1.01 | 0.92 | |
| 377_L | 451_L | 1.01 | 0.92 | |
| 454_L | 480_L | 1.008 | 0.92 | |
| 604_Q | 607_A | 1.008 | 0.92 | |
| 413_Y | 446_W | 1 | 0.91 | |
| 115_G | 119_A | 1 | 0.91 | |
| 357_L | 365_V | 1 | 0.91 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4finA | 2 | 0.8399 | 100 | 0.372 | Contact Map | 0.777 |
| 2iw3A | 2 | 0.6876 | 100 | 0.468 | Contact Map | 0.778 |
| 3bk7A | 1 | 0.7645 | 100 | 0.518 | Contact Map | 0.604 |
| 1yqtA | 1 | 0.7394 | 100 | 0.519 | Contact Map | 0.64 |
| 3g5uA | 2 | 0.8038 | 100 | 0.523 | Contact Map | 0.679 |
| 4f4cA | 1 | 0.7896 | 100 | 0.53 | Contact Map | 0.751 |
| 3ozxA | 2 | 0.7912 | 100 | 0.536 | Contact Map | 0.689 |
| 3j16B | 1 | 0.7834 | 100 | 0.546 | Contact Map | 0.428 |
| 3ux8A | 1 | 0.7394 | 100 | 0.572 | Contact Map | 0.585 |
| 2vf7A | 3 | 0.7159 | 100 | 0.656 | Contact Map | 0.531 |
Sequence Conservation (Image Generated using WebLogo v3)