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YDCU - Inner membrane ABC transporter permease protein YdcU
UniProt: P77156 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13764
Length: 313 (276)
Sequences: 14602
Seq/Len: 52.91
YDCU
Paralog alert: 0.88 [within 20: 0.56] - ratio of genomes with paralogs
Cluster includes: CYST CYSW MALG MODB POTB POTC POTH POTI PSTA PSTC UGPA UGPE YCJO YCJP YDCU YDCV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
227_Q 231_Y 4.322 1.00
55_G 75_I 3.921 1.00
226_R 230_R 3.157 1.00
88_L 92_T 3.138 1.00
219_A 228_T 3.108 1.00
224_R 227_Q 3.105 1.00
73_A 76_R 2.835 1.00
215_L 233_V 2.816 1.00
73_A 77_A 2.62 1.00
225_P 228_T 2.583 1.00
100_A 192_L 2.335 1.00
84_Y 88_L 2.297 1.00
203_V 241_I 2.274 1.00
157_L 162_L 2.249 1.00
106_F 237_A 2.195 1.00
183_S 266_G 2.161 1.00
227_Q 230_R 2.139 1.00
267_Y 275_S 2.116 1.00
85_D 88_L 2.059 1.00
96_A 188_F 2.048 1.00
52_L 291_L 2.032 1.00
53_W 57_Y 1.996 1.00
218_S 228_T 1.992 1.00
214_L 236_L 1.951 1.00
75_I 291_L 1.919 1.00
218_S 223_A 1.892 1.00
215_L 228_T 1.886 1.00
92_T 184_G 1.876 1.00
85_D 89_R 1.856 1.00
77_A 285_M 1.815 1.00
146_L 153_A 1.788 1.00
102_A 245_S 1.757 1.00
106_F 203_V 1.742 1.00
234_L 241_I 1.739 1.00
98_T 245_S 1.688 1.00
243_A 247_F 1.683 1.00
147_L 186_G 1.665 1.00
112_M 200_I 1.657 1.00
154_Q 168_A 1.649 1.00
46_G 50_T 1.642 1.00
114_R 215_L 1.642 1.00
113_A 208_E 1.613 1.00
72_L 76_R 1.603 1.00
105_A 199_M 1.597 1.00
106_F 229_F 1.596 1.00
206_A 237_A 1.588 1.00
282_N 285_M 1.586 1.00
223_A 227_Q 1.584 1.00
204_Q 208_E 1.574 1.00
199_M 244_G 1.572 1.00
113_A 204_Q 1.529 1.00
50_T 54_Q 1.526 1.00
185_L 189_L 1.52 1.00
86_I 272_M 1.512 1.00
108_M 200_I 1.499 1.00
78_L 292_V 1.498 1.00
256_F 260_Q 1.498 1.00
110_W 207_L 1.497 1.00
154_Q 157_L 1.472 1.00
190_V 262_V 1.466 1.00
156_F 160_L 1.464 1.00
207_L 237_A 1.46 1.00
123_F 127_A 1.45 1.00
229_F 234_L 1.445 1.00
49_L 53_W 1.44 1.00
256_F 274_Y 1.409 1.00
155_W 159_H 1.401 0.99
210_L 237_A 1.4 0.99
75_I 288_A 1.397 0.99
94_A 249_F 1.391 0.99
210_L 236_L 1.39 0.99
224_R 228_T 1.39 0.99
206_A 240_G 1.388 0.99
272_M 289_F 1.388 0.99
276_Q 280_I 1.371 0.99
203_V 244_G 1.363 0.99
215_L 219_A 1.342 0.99
272_M 276_Q 1.331 0.99
276_Q 282_N 1.328 0.99
277_Q 286_A 1.327 0.99
92_T 96_A 1.325 0.99
167_T 170_L 1.32 0.99
77_A 282_N 1.314 0.99
196_L 200_I 1.313 0.99
117_S 120_M 1.307 0.99
218_S 232_V 1.293 0.99
74_N 284_P 1.291 0.99
50_T 53_W 1.289 0.99
171_T 182_T 1.288 0.99
236_L 239_P 1.285 0.99
87_I 269_I 1.282 0.99
273_V 289_F 1.282 0.99
117_S 121_K 1.277 0.99
91_L 95_V 1.274 0.99
184_G 188_F 1.247 0.99
219_A 225_P 1.243 0.98
199_M 248_T 1.234 0.98
58_T 68_P 1.221 0.98
156_F 159_H 1.215 0.98
190_V 258_V 1.215 0.98
268_F 271_N 1.212 0.98
71_T 74_N 1.206 0.98
110_W 229_F 1.195 0.98
103_I 107_P 1.191 0.98
276_Q 289_F 1.189 0.98
199_M 203_V 1.179 0.98
140_A 261_L 1.175 0.98
155_W 158_Q 1.173 0.98
90_T 270_G 1.172 0.98
78_L 285_M 1.154 0.97
121_K 208_E 1.151 0.97
230_R 234_L 1.149 0.97
113_A 207_L 1.131 0.97
34_L 38_M 1.117 0.96
51_L 291_L 1.117 0.96
171_T 174_A 1.116 0.96
267_Y 271_N 1.108 0.96
101_S 105_A 1.101 0.96
101_S 248_T 1.099 0.96
82_A 85_D 1.098 0.96
238_I 241_I 1.097 0.96
95_V 99_I 1.091 0.96
93_M 191_F 1.09 0.96
92_T 185_L 1.084 0.96
213_S 216_Q 1.076 0.95
158_Q 164_P 1.064 0.95
89_R 92_T 1.063 0.95
90_T 269_I 1.061 0.95
107_P 111_Y 1.052 0.95
207_L 233_V 1.047 0.94
137_I 261_L 1.043 0.94
259_P 268_F 1.042 0.94
97_V 252_T 1.033 0.94
275_S 279_A 1.031 0.94
99_I 103_I 1.031 0.94
96_A 100_A 1.03 0.94
57_Y 69_E 1.025 0.93
202_P 244_G 1.021 0.93
97_V 191_F 1.02 0.93
96_A 99_I 1.018 0.93
86_I 269_I 1.016 0.93
182_T 185_L 1.015 0.93
285_M 289_F 1.008 0.93
84_Y 87_I 1.004 0.93
80_N 285_M 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2onkC40.87541000.393Contact Map0.74
3d31C20.89781000.413Contact Map0.675
3rlfF10.96491000.455Contact Map0.66
3rlfG10.8691000.46Contact Map0.755
3tuiA40.670999.90.611Contact Map0.772
3hxiC10.03191.80.972Contact Map
2knuA10.06711.70.972Contact Map
2ki9A10.10541.70.972Contact Map0.152
2gfpA20.21411.70.972Contact Map0.247
1iijA10.11181.60.972Contact Map0.646
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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