May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
CYST - Sulfate transport system permease protein CysT
UniProt: P16701 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10197
Length: 277 (256)
Sequences: 24523
Seq/Len: 95.79
CYST
Paralog alert: 0.93 [within 20: 0.82] - ratio of genomes with paralogs
Cluster includes: CYST CYSW MALG MODB POTB POTC POTH POTI PSTA PSTC UGPA UGPE YCJO YCJP YDCU YDCV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
183_Q 187_K 4.276 1.00
61_K 65_L 3.33 1.00
39_L 47_Y 3.299 1.00
180_T 183_Q 2.728 1.00
182_W 186_C 2.642 1.00
175_E 184_S 2.536 1.00
171_E 189_V 2.519 1.00
45_A 48_W 2.451 1.00
160_Q 164_E 2.415 1.00
45_A 49_E 2.398 1.00
59_A 232_M 2.357 1.00
73_F 148_A 2.288 1.00
174_A 184_S 2.264 1.00
181_R 184_S 2.252 1.00
57_V 61_K 2.244 1.00
159_V 197_L 2.234 1.00
87_R 171_E 2.207 1.00
58_A 61_K 2.198 1.00
48_W 52_T 2.133 1.00
71_S 201_V 2.107 1.00
69_V 144_A 2.107 1.00
163_L 193_L 2.078 1.00
79_L 185_F 2.062 1.00
227_E 235_V 2.021 1.00
162_V 196_A 1.999 1.00
179_A 183_Q 1.995 1.00
155_V 200_G 1.936 1.00
86_T 164_E 1.926 1.00
241_D 244_A 1.91 1.00
183_Q 186_C 1.862 1.00
175_E 181_R 1.851 1.00
67_A 205_F 1.788 1.00
79_L 193_L 1.777 1.00
90_F 93_R 1.761 1.00
75_G 201_V 1.731 1.00
65_L 140_W 1.73 1.00
36_V 250_S 1.725 1.00
129_L 134_I 1.718 1.00
33_S 37_M 1.716 1.00
170_Y 192_E 1.698 1.00
174_A 179_A 1.69 1.00
171_E 184_S 1.627 1.00
37_M 41_Q 1.625 1.00
78_G 155_V 1.621 1.00
79_L 159_V 1.617 1.00
58_A 62_V 1.611 1.00
139_T 226_T 1.604 1.00
89_R 93_R 1.583 1.00
212_F 234_F 1.579 1.00
49_E 244_A 1.566 1.00
190_L 197_L 1.562 1.00
47_Y 250_S 1.557 1.00
65_L 69_V 1.518 1.00
171_E 175_E 1.457 1.00
86_T 160_Q 1.447 1.00
155_V 204_S 1.441 1.00
76_V 80_L 1.435 1.00
82_A 159_V 1.432 1.00
85_L 156_V 1.426 1.00
87_R 168_P 1.411 1.00
180_T 184_S 1.386 0.99
212_F 216_I 1.385 0.99
81_M 156_V 1.385 0.99
221_N 225_K 1.374 0.99
70_A 208_S 1.374 0.99
261_F 265_T 1.357 0.99
159_V 200_G 1.347 0.99
119_F 142_G 1.339 0.99
92_G 95_L 1.333 0.99
140_W 226_T 1.325 0.99
199_A 203_L 1.314 0.99
141_L 145_V 1.307 0.99
30_L 34_A 1.302 0.99
163_L 189_V 1.298 0.99
174_A 188_V 1.281 0.99
44_W 48_W 1.274 0.99
168_P 171_E 1.27 0.99
43_S 46_Q 1.269 0.99
66_S 228_V 1.261 0.99
60_Y 229_T 1.25 0.99
166_L 192_E 1.242 0.98
34_A 38_Q 1.224 0.98
169_E 172_E 1.214 0.98
126_G 129_L 1.214 0.98
79_L 197_L 1.211 0.98
64_L 68_F 1.203 0.98
224_W 227_E 1.199 0.98
97_D 160_Q 1.194 0.98
127_E 131_K 1.193 0.98
46_Q 243_P 1.193 0.98
219_A 222_I 1.19 0.98
192_E 195_P 1.185 0.98
138_Y 221_N 1.181 0.98
146_A 218_I 1.173 0.98
63_T 230_S 1.16 0.97
83_W 163_L 1.144 0.97
49_E 52_T 1.141 0.97
69_V 73_F 1.141 0.97
185_F 190_L 1.137 0.97
140_W 144_A 1.136 0.97
62_V 65_L 1.13 0.97
179_A 184_S 1.128 0.97
68_F 72_I 1.125 0.97
152_I 156_V 1.125 0.97
128_W 132_F 1.125 0.97
214_A 218_I 1.121 0.97
73_F 144_A 1.11 0.96
69_V 72_I 1.104 0.96
236_R 241_D 1.104 0.96
228_V 231_L 1.101 0.96
38_Q 246_S 1.094 0.96
50_V 251_V 1.092 0.96
47_Y 247_A 1.088 0.96
74_N 204_S 1.086 0.96
128_W 131_K 1.074 0.95
72_I 76_V 1.072 0.95
95_L 99_L 1.071 0.95
162_V 193_L 1.066 0.95
35_L 250_S 1.064 0.95
118_L 125_Y 1.058 0.95
86_T 163_L 1.047 0.94
65_L 68_F 1.046 0.94
74_N 78_G 1.043 0.94
232_M 248_I 1.042 0.94
215_V 228_V 1.038 0.94
232_M 236_R 1.036 0.94
80_L 84_I 1.033 0.94
61_K 64_L 1.026 0.94
70_A 147_M 1.022 0.93
49_E 53_N 1.01 0.93
147_M 208_S 1.009 0.93
95_L 98_A 1.008 0.93
194_S 197_L 1.002 0.92
236_R 248_I 1.002 0.92
49_E 241_D 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2onkC40.97111000.346Contact Map0.749
3d31C20.97831000.363Contact Map0.678
3rlfG10.96031000.429Contact Map0.763
3rlfF10.97471000.44Contact Map0.666
3tuiA40.754599.90.574Contact Map0.769
4b19A10.10833.70.963Contact Map0.438
2kv5A10.11912.50.966Contact Map0.478
2kluA10.14442.40.966Contact Map0
2l2tA20.1482.30.967Contact Map0.593
4gxbB10.06142.30.967Contact Map
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0166 seconds.