May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YCJO - Inner membrane ABC transporter permease protein YcjO
UniProt: P0AFR7 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13912
Length: 293 (274)
Sequences: 22385
Seq/Len: 81.70
YCJO
Paralog alert: 0.95 [within 20: 0.79] - ratio of genomes with paralogs
Cluster includes: CYST CYSW MALG MODB POTB POTC POTH POTI PSTA PSTC UGPA UGPE YCJO YCJP YDCU YDCV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
206_Q 210_I 4.629 1.00
40_S 60_Y 3.802 1.00
74_W 78_W 3.269 1.00
203_N 206_Q 2.925 1.00
205_W 209_R 2.877 1.00
198_E 207_R 2.708 1.00
58_S 61_V 2.681 1.00
183_L 187_Q 2.645 1.00
194_Y 212_T 2.593 1.00
58_S 62_R 2.572 1.00
182_F 220_L 2.409 1.00
70_W 74_W 2.379 1.00
71_H 74_W 2.373 1.00
86_G 171_I 2.339 1.00
92_L 208_F 2.336 1.00
186_L 216_I 2.329 1.00
100_R 194_Y 2.307 1.00
61_V 65_S 2.285 1.00
204_A 207_R 2.261 1.00
72_S 251_Y 2.247 1.00
197_A 207_R 2.135 1.00
82_L 167_V 2.076 1.00
84_V 224_V 2.067 1.00
202_A 206_Q 2.062 1.00
178_A 223_V 2.012 1.00
206_Q 209_R 1.994 1.00
99_N 187_Q 1.95 1.00
246_D 254_K 1.943 1.00
37_I 270_V 1.929 1.00
60_Y 270_V 1.85 1.00
92_L 216_I 1.839 1.00
193_L 215_A 1.83 1.00
80_T 228_T 1.823 1.00
71_H 75_M 1.799 1.00
88_T 224_V 1.788 1.00
197_A 202_A 1.786 1.00
185_I 219_V 1.784 1.00
102_F 105_R 1.781 1.00
198_E 204_A 1.777 1.00
91_G 178_A 1.771 1.00
261_D 264_K 1.758 1.00
162_S 245_V 1.743 1.00
34_V 38_E 1.715 1.00
92_L 182_F 1.694 1.00
194_Y 207_R 1.689 1.00
38_E 42_L 1.685 1.00
62_R 264_K 1.663 1.00
213_L 220_L 1.649 1.00
78_W 82_L 1.591 1.00
101_E 105_R 1.525 1.00
56_G 59_N 1.508 1.00
235_F 253_Y 1.495 1.00
235_F 239_Y 1.488 1.00
99_N 183_L 1.485 1.00
94_V 179_F 1.472 1.00
194_Y 198_E 1.472 1.00
57_V 61_V 1.471 1.00
222_T 226_L 1.471 1.00
178_A 227_R 1.469 1.00
83_V 231_M 1.468 1.00
203_N 207_R 1.458 1.00
98_F 179_F 1.437 1.00
59_N 263_G 1.431 1.00
197_A 211_V 1.422 1.00
182_F 223_V 1.412 1.00
100_R 191_K 1.409 1.00
104_L 107_T 1.39 0.99
95_A 182_F 1.376 0.99
31_W 35_S 1.375 0.99
41_F 55_V 1.372 0.99
89_V 93_A 1.366 0.99
189_I 215_A 1.353 0.99
186_L 212_T 1.351 0.99
237_D 241_L 1.333 0.99
76_T 249_G 1.313 0.99
191_K 194_Y 1.312 0.99
242_T 245_V 1.297 0.99
164_V 168_L 1.288 0.99
35_S 39_I 1.288 0.99
63_I 271_V 1.288 0.99
77_V 81_A 1.285 0.99
215_A 218_P 1.279 0.99
185_I 216_I 1.258 0.99
208_F 213_L 1.255 0.99
139_N 155_W 1.249 0.99
192_S 195_E 1.238 0.98
202_A 207_R 1.235 0.98
92_L 220_L 1.231 0.98
131_F 165_L 1.226 0.98
158_N 161_S 1.223 0.98
62_R 65_S 1.221 0.98
73_L 248_L 1.218 0.98
247_I 250_V 1.215 0.98
60_Y 267_A 1.214 0.98
78_W 163_F 1.192 0.98
75_M 78_W 1.165 0.97
87_S 91_G 1.165 0.97
96_M 186_L 1.157 0.97
109_R 183_L 1.141 0.97
107_T 111_L 1.14 0.97
43_R 53_T 1.132 0.97
81_A 85_A 1.132 0.97
39_I 266_A 1.129 0.97
79_Y 247_I 1.123 0.97
36_N 270_V 1.114 0.96
82_L 86_G 1.107 0.96
251_Y 268_I 1.101 0.96
62_R 261_D 1.1 0.96
82_L 85_A 1.098 0.96
194_Y 204_A 1.097 0.96
41_F 56_G 1.096 0.96
175_F 179_F 1.088 0.96
178_A 182_F 1.085 0.96
251_Y 255_T 1.081 0.95
87_S 227_R 1.078 0.95
78_W 81_A 1.074 0.95
124_V 240_L 1.072 0.95
154_L 157_D 1.071 0.95
217_M 220_L 1.07 0.95
189_I 216_I 1.067 0.95
182_F 219_V 1.064 0.95
163_F 167_V 1.063 0.95
246_D 250_V 1.058 0.95
130_M 138_V 1.056 0.95
64_L 70_W 1.055 0.95
255_T 259_F 1.052 0.95
107_T 110_S 1.048 0.94
74_W 77_V 1.046 0.94
96_M 208_F 1.041 0.94
93_A 97_F 1.035 0.94
234_M 238_V 1.035 0.94
141_L 245_V 1.032 0.94
169_F 241_L 1.029 0.94
36_N 266_A 1.028 0.94
88_T 220_L 1.026 0.94
68_G 71_H 1.026 0.94
83_V 170_A 1.025 0.93
85_A 89_V 1.021 0.93
76_T 248_L 1.019 0.93
62_R 66_D 1.014 0.93
80_T 84_V 1.011 0.93
23_L 27_G 1.009 0.93
99_N 186_L 1.003 0.93
83_V 87_S 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2onkC40.90441000.343Contact Map0.746
3d31C20.91131000.363Contact Map0.665
3rlfF10.98631000.394Contact Map0.635
3rlfG10.93171000.398Contact Map0.757
3tuiA40.713399.90.576Contact Map0.745
3oglQ70.0412.40.966Contact Map
2m8rA10.12972.20.967Contact Map0
3hd7B20.12972.20.967Contact Map0.013
2yp5A10.19820.967Contact Map0.303
2mc7A10.10241.80.968Contact Map0.373
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0479 seconds.