| UniProt: | P68183 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10556 | ||
| Length: | 296 (270) | ||
| Sequences: | 22350 | ||
| Seq/Len: | 82.78 |
| MALG
Paralog alert: 0.95 [within 20: 0.80] - ratio of genomes with paralogs Cluster includes: CYST CYSW MALG MODB POTB POTC POTH POTI PSTA PSTC UGPA UGPE YCJO YCJP YDCU YDCV |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 201_Q | 205_L | 4.759 | 1.00 | |
| 38_S | 59_W | 3.979 | 1.00 | |
| 86_W | 90_K | 3.355 | 1.00 | |
| 198_T | 201_Q | 3.008 | 1.00 | |
| 200_W | 204_R | 2.962 | 1.00 | |
| 57_D | 60_K | 2.804 | 1.00 | |
| 178_K | 182_E | 2.681 | 1.00 | |
| 193_A | 202_A | 2.677 | 1.00 | |
| 189_E | 207_L | 2.669 | 1.00 | |
| 57_D | 61_L | 2.598 | 1.00 | |
| 83_L | 86_W | 2.515 | 1.00 | |
| 177_I | 215_L | 2.44 | 1.00 | |
| 82_L | 86_W | 2.395 | 1.00 | |
| 104_T | 203_F | 2.389 | 1.00 | |
| 98_G | 167_L | 2.37 | 1.00 | |
| 112_R | 189_E | 2.322 | 1.00 | |
| 60_K | 64_G | 2.28 | 1.00 | |
| 181_F | 211_S | 2.276 | 1.00 | |
| 199_P | 202_A | 2.264 | 1.00 | |
| 84_W | 248_G | 2.218 | 1.00 | |
| 192_A | 202_A | 2.151 | 1.00 | |
| 96_A | 219_F | 2.132 | 1.00 | |
| 35_V | 268_V | 2.117 | 1.00 | |
| 94_I | 163_I | 2.08 | 1.00 | |
| 197_A | 201_Q | 2.066 | 1.00 | |
| 201_Q | 204_R | 2.017 | 1.00 | |
| 111_A | 182_E | 1.969 | 1.00 | |
| 173_H | 218_V | 1.946 | 1.00 | |
| 115_F | 118_K | 1.873 | 1.00 | |
| 92_A | 223_F | 1.851 | 1.00 | |
| 188_L | 210_L | 1.844 | 1.00 | |
| 83_L | 87_N | 1.842 | 1.00 | |
| 104_T | 211_S | 1.831 | 1.00 | |
| 193_A | 199_P | 1.824 | 1.00 | |
| 103_S | 173_H | 1.802 | 1.00 | |
| 192_A | 197_A | 1.775 | 1.00 | |
| 180_Y | 214_I | 1.771 | 1.00 | |
| 100_V | 219_F | 1.764 | 1.00 | |
| 32_L | 36_A | 1.754 | 1.00 | |
| 36_A | 40_R | 1.747 | 1.00 | |
| 104_T | 177_I | 1.735 | 1.00 | |
| 189_E | 202_A | 1.73 | 1.00 | |
| 61_L | 262_D | 1.682 | 1.00 | |
| 208_L | 215_L | 1.659 | 1.00 | |
| 59_W | 268_V | 1.645 | 1.00 | |
| 259_L | 262_D | 1.635 | 1.00 | |
| 90_K | 94_I | 1.632 | 1.00 | |
| 114_R | 118_K | 1.603 | 1.00 | |
| 95_S | 226_A | 1.596 | 1.00 | |
| 56_W | 60_K | 1.551 | 1.00 | |
| 217_V | 221_L | 1.525 | 1.00 | |
| 112_R | 186_S | 1.509 | 1.00 | |
| 55_S | 58_H | 1.495 | 1.00 | |
| 173_H | 222_S | 1.495 | 1.00 | |
| 111_A | 178_K | 1.493 | 1.00 | |
| 29_F | 33_M | 1.48 | 1.00 | |
| 243_Y | 251_Q | 1.476 | 1.00 | |
| 106_C | 174_V | 1.474 | 1.00 | |
| 189_E | 193_A | 1.474 | 1.00 | |
| 107_A | 177_I | 1.445 | 1.00 | |
| 198_T | 202_A | 1.434 | 1.00 | |
| 117_G | 120_T | 1.43 | 1.00 | |
| 110_F | 174_V | 1.425 | 1.00 | |
| 90_K | 159_H | 1.404 | 0.99 | |
| 177_I | 218_V | 1.402 | 0.99 | |
| 192_A | 206_V | 1.401 | 0.99 | |
| 58_H | 261_G | 1.339 | 0.99 | |
| 89_V | 93_G | 1.337 | 0.99 | |
| 101_A | 105_T | 1.332 | 0.99 | |
| 186_S | 189_E | 1.329 | 0.99 | |
| 184_I | 210_L | 1.325 | 0.99 | |
| 62_A | 269_M | 1.317 | 0.99 | |
| 88_S | 246_A | 1.301 | 0.99 | |
| 248_G | 252_Y | 1.3 | 0.99 | |
| 37_I | 264_A | 1.295 | 0.99 | |
| 181_F | 207_L | 1.292 | 0.99 | |
| 33_M | 37_I | 1.29 | 0.99 | |
| 203_F | 208_L | 1.287 | 0.99 | |
| 187_S | 190_E | 1.282 | 0.99 | |
| 180_Y | 211_S | 1.262 | 0.99 | |
| 61_L | 259_L | 1.254 | 0.99 | |
| 157_N | 239_D | 1.253 | 0.99 | |
| 230_V | 250_Q | 1.249 | 0.99 | |
| 99_I | 103_S | 1.248 | 0.99 | |
| 197_A | 202_A | 1.247 | 0.99 | |
| 39_L | 54_I | 1.247 | 0.99 | |
| 104_T | 215_L | 1.244 | 0.98 | |
| 99_I | 222_S | 1.242 | 0.98 | |
| 210_L | 213_P | 1.238 | 0.98 | |
| 232_V | 236_L | 1.235 | 0.98 | |
| 159_H | 242_S | 1.234 | 0.98 | |
| 34_V | 268_V | 1.229 | 0.98 | |
| 230_V | 234_S | 1.215 | 0.98 | |
| 120_T | 124_G | 1.204 | 0.98 | |
| 108_Y | 181_F | 1.202 | 0.98 | |
| 61_L | 64_G | 1.2 | 0.98 | |
| 93_G | 97_I | 1.179 | 0.98 | |
| 87_N | 90_K | 1.178 | 0.98 | |
| 94_I | 98_G | 1.172 | 0.98 | |
| 94_I | 97_I | 1.168 | 0.97 | |
| 59_W | 265_A | 1.163 | 0.97 | |
| 177_I | 214_I | 1.157 | 0.97 | |
| 245_L | 253_L | 1.151 | 0.97 | |
| 244_T | 247_V | 1.148 | 0.97 | |
| 189_E | 199_P | 1.121 | 0.97 | |
| 212_V | 215_L | 1.118 | 0.96 | |
| 21_L | 25_A | 1.113 | 0.96 | |
| 184_I | 211_S | 1.111 | 0.96 | |
| 137_L | 235_L | 1.11 | 0.96 | |
| 63_L | 82_L | 1.1 | 0.96 | |
| 95_S | 166_Y | 1.097 | 0.96 | |
| 91_V | 244_T | 1.097 | 0.96 | |
| 122_L | 178_K | 1.094 | 0.96 | |
| 170_I | 174_V | 1.091 | 0.96 | |
| 90_K | 93_G | 1.089 | 0.96 | |
| 105_T | 109_A | 1.077 | 0.95 | |
| 239_D | 242_S | 1.074 | 0.95 | |
| 173_H | 177_I | 1.071 | 0.95 | |
| 165_A | 236_L | 1.07 | 0.95 | |
| 86_W | 89_V | 1.062 | 0.95 | |
| 120_T | 123_K | 1.06 | 0.95 | |
| 92_A | 96_A | 1.053 | 0.95 | |
| 166_Y | 226_A | 1.044 | 0.94 | |
| 97_I | 101_A | 1.041 | 0.94 | |
| 100_V | 215_L | 1.037 | 0.94 | |
| 95_S | 99_I | 1.034 | 0.94 | |
| 229_E | 233_A | 1.034 | 0.94 | |
| 39_L | 55_S | 1.033 | 0.94 | |
| 33_M | 36_A | 1.031 | 0.94 | |
| 108_Y | 203_F | 1.03 | 0.94 | |
| 17_H | 21_L | 1.016 | 0.93 | |
| 203_F | 207_L | 1.014 | 0.93 | |
| 240_V | 243_Y | 1.014 | 0.93 | |
| 34_V | 264_A | 1.005 | 0.93 | |
| 98_G | 163_I | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3rlfG | 1 | 1 | 100 | 0.318 | Contact Map | 0.765 |
| 2onkC | 4 | 0.8919 | 100 | 0.416 | Contact Map | 0.749 |
| 3d31C | 2 | 0.8919 | 100 | 0.427 | Contact Map | 0.675 |
| 3rlfF | 1 | 0.9493 | 100 | 0.461 | Contact Map | 0.622 |
| 3tuiA | 4 | 0.7027 | 99.9 | 0.59 | Contact Map | 0.753 |
| 1fjkA | 1 | 0.1182 | 4.4 | 0.962 | Contact Map | 0.666 |
| 4kytB | 2 | 0.1182 | 3.8 | 0.963 | Contact Map | 0.009 |
| 4b19A | 1 | 0.1014 | 3.1 | 0.965 | Contact Map | 0.473 |
| 2kv5A | 1 | 0.1115 | 2.2 | 0.968 | Contact Map | 0.423 |
| 1iijA | 1 | 0.1182 | 1.6 | 0.97 | Contact Map | 0.624 |
Sequence Conservation (Image Generated using WebLogo v3)