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CYSW - Sulfate transport system permease protein CysW
UniProt: P0AEB0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10198
Length: 291 (258)
Sequences: 19586
Seq/Len: 75.91
CYSW
Paralog alert: 0.94 [within 20: 0.80] - ratio of genomes with paralogs
Cluster includes: CYST CYSW MALG MODB POTB POTC POTH POTI PSTA PSTC UGPA UGPE YCJO YCJP YDCU YDCV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
189_Q 193_R 4.126 1.00
45_A 53_V 3.791 1.00
67_W 71_M 3.271 1.00
188_W 192_R 2.911 1.00
186_S 189_Q 2.764 1.00
181_I 190_M 2.652 1.00
177_D 195_T 2.576 1.00
51_M 54_L 2.527 1.00
187_G 190_M 2.383 1.00
79_V 154_I 2.341 1.00
180_A 190_M 2.313 1.00
63_L 67_W 2.298 1.00
51_M 55_Q 2.29 1.00
54_L 58_A 2.207 1.00
165_L 203_L 2.198 1.00
93_R 177_D 2.184 1.00
75_I 150_V 2.16 1.00
166_V 170_L 2.135 1.00
64_H 67_W 2.119 1.00
189_Q 192_R 2.074 1.00
77_V 207_V 2.033 1.00
65_A 238_Q 2.013 1.00
233_L 241_L 1.985 1.00
161_V 206_G 1.95 1.00
169_M 199_I 1.938 1.00
85_I 199_I 1.929 1.00
176_E 198_N 1.865 1.00
168_V 202_A 1.854 1.00
135_L 140_L 1.844 1.00
92_T 170_L 1.842 1.00
85_I 191_F 1.808 1.00
247_N 250_G 1.802 1.00
43_V 47_S 1.789 1.00
145_S 232_T 1.782 1.00
71_M 146_W 1.755 1.00
81_L 207_V 1.749 1.00
96_F 99_R 1.739 1.00
53_V 256_A 1.717 1.00
185_A 189_Q 1.714 1.00
42_F 256_A 1.697 1.00
85_I 165_L 1.689 1.00
84_G 161_V 1.688 1.00
180_A 185_A 1.654 1.00
55_Q 250_G 1.643 1.00
64_H 68_L 1.64 1.00
177_D 190_M 1.635 1.00
196_L 203_L 1.625 1.00
181_I 187_G 1.598 1.00
92_T 166_V 1.573 1.00
73_A 211_N 1.569 1.00
39_I 43_V 1.563 1.00
125_Y 148_G 1.512 1.00
267_F 271_M 1.491 1.00
218_F 240_E 1.484 1.00
218_F 222_S 1.473 1.00
71_M 75_I 1.462 1.00
165_L 206_G 1.455 1.00
91_V 162_V 1.451 1.00
95_N 99_R 1.443 1.00
205_Y 209_L 1.433 1.00
36_V 40_Y 1.423 1.00
161_V 210_T 1.412 1.00
186_S 190_M 1.395 0.99
87_L 162_V 1.394 0.99
177_D 181_I 1.383 0.99
147_P 151_L 1.35 0.99
124_F 131_L 1.347 0.99
50_L 54_L 1.338 0.99
180_A 194_V 1.323 0.99
82_V 86_L 1.319 0.99
40_Y 44_Q 1.318 0.99
152_V 224_V 1.308 0.99
132_G 135_L 1.294 0.99
169_M 195_T 1.288 0.99
133_G 137_E 1.278 0.99
52_P 249_V 1.268 0.99
238_Q 254_A 1.268 0.99
66_I 235_L 1.264 0.99
88_A 165_L 1.259 0.99
172_Q 198_N 1.253 0.99
132_G 142_I 1.248 0.99
53_V 253_T 1.239 0.98
89_W 169_M 1.226 0.98
101_L 105_L 1.223 0.98
198_N 201_W 1.215 0.98
70_V 74_L 1.213 0.98
146_W 150_V 1.209 0.98
161_V 165_L 1.204 0.98
134_W 138_H 1.204 0.98
191_F 196_L 1.202 0.98
175_Q 178_E 1.199 0.98
168_V 199_I 1.194 0.98
49_G 52_P 1.189 0.98
76_A 214_A 1.184 0.98
56_N 257_L 1.178 0.98
238_Q 242_L 1.172 0.98
230_G 233_L 1.155 0.97
242_L 247_N 1.135 0.97
98_G 101_L 1.132 0.97
234_S 237_L 1.131 0.97
242_L 245_D 1.13 0.97
69_T 236_P 1.13 0.97
69_T 235_L 1.114 0.96
227_S 231_E 1.113 0.96
158_C 162_V 1.113 0.96
134_W 137_E 1.104 0.96
75_I 79_V 1.102 0.96
68_L 71_M 1.102 0.96
41_I 256_A 1.098 0.96
76_A 153_T 1.089 0.96
74_L 78_P 1.089 0.96
103_L 166_V 1.086 0.96
40_Y 43_V 1.083 0.96
93_R 174_S 1.082 0.96
153_T 214_A 1.076 0.95
172_Q 199_I 1.075 0.95
133_G 136_D 1.066 0.95
191_F 195_T 1.053 0.95
164_E 206_G 1.053 0.95
79_V 150_V 1.052 0.95
271_M 274_W 1.049 0.94
55_Q 58_A 1.048 0.94
85_I 203_L 1.048 0.94
92_T 169_M 1.046 0.94
233_L 237_L 1.045 0.94
99_R 170_L 1.043 0.94
185_A 190_M 1.039 0.94
132_G 227_S 1.038 0.94
80_N 210_T 1.037 0.94
78_P 82_V 1.036 0.94
89_W 191_F 1.032 0.94
174_S 177_D 1.025 0.93
67_W 70_V 1.024 0.93
146_W 232_T 1.024 0.93
55_Q 247_N 1.018 0.93
86_L 90_L 1.018 0.93
187_G 191_F 1.018 0.93
220_A 224_V 1.014 0.93
118_G 223_V 1.011 0.93
200_R 203_L 1.008 0.93
192_R 196_L 1.008 0.93
80_N 84_G 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2onkC40.9451000.431Contact Map0.75
3d31C20.94851000.447Contact Map0.679
3rlfG10.91751000.51Contact Map0.76
3rlfF10.9451000.514Contact Map0.669
3tuiA40.718299.90.635Contact Map0.771
2xq2A10.793819.60.957Contact Map0.226
2l8sA10.1753110.961Contact Map0.002
4ainA30.86948.50.963Contact Map0.345
4c7rA30.86948.10.964Contact Map0.321
2l2tA20.14785.70.966Contact Map0.842
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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