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OPENSEQ.org
YFCS - Uncharacterized fimbrial chaperone YfcS
UniProt: P77599 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14122
Length: 250 (217)
Sequences: 1340
Seq/Len: 6.18
YFCS
Paralog alert: 0.90 [within 20: 0.51] - ratio of genomes with paralogs
Cluster includes: ECPD ELFD FIMC SFMC YBGP YCBF YEHC YFCS YHCA YQIH YRAI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
32_P 138_I 3.042 1.00
105_L 113_F 2.941 1.00
180_I 200_V 2.869 1.00
112_M 200_V 2.837 1.00
178_Y 202_E 2.768 1.00
40_N 43_D 2.556 1.00
109_R 204_K 2.553 1.00
202_E 205_T 2.535 1.00
141_F 200_V 2.484 1.00
65_I 140_L 2.312 1.00
172_N 206_T 2.302 1.00
161_T 172_N 2.299 1.00
37_L 46_I 2.24 1.00
59_Y 119_E 2.204 1.00
37_L 115_F 2.203 1.00
37_L 96_V 2.192 1.00
58_P 87_D 2.12 1.00
64_W 116_N 2.087 1.00
66_E 137_R 2.077 1.00
58_P 85_R 2.038 1.00
171_V 209_L 1.956 1.00
41_E 107_A 1.948 1.00
106_P 111_S 1.937 1.00
116_N 137_R 1.82 1.00
147_L 177_Y 1.766 1.00
118_R 135_Q 1.749 1.00
223_N 229_M 1.742 1.00
112_M 180_I 1.711 1.00
77_L 96_V 1.687 1.00
106_P 109_R 1.651 1.00
87_D 90_M 1.644 1.00
170_T 208_P 1.64 1.00
66_E 116_N 1.626 1.00
179_V 221_Y 1.55 0.99
96_V 140_L 1.544 0.99
42_S 145_K 1.514 0.99
30_V 86_I 1.51 0.99
40_N 46_I 1.493 0.99
223_N 227_A 1.471 0.99
160_V 171_V 1.461 0.99
98_G 101_D 1.454 0.99
50_L 61_A 1.453 0.99
201_I 207_V 1.429 0.99
32_P 48_V 1.414 0.98
32_P 117_V 1.393 0.98
141_F 178_Y 1.385 0.98
31_T 34_R 1.378 0.98
153_K 156_W 1.366 0.98
39_F 46_I 1.365 0.98
180_I 221_Y 1.345 0.98
49_T 91_N 1.343 0.98
170_T 206_T 1.336 0.98
101_D 104_K 1.33 0.97
79_V 94_V 1.33 0.97
37_L 138_I 1.297 0.97
29_S 119_E 1.291 0.97
79_V 115_F 1.282 0.97
66_E 114_Y 1.279 0.97
94_V 115_F 1.272 0.96
163_T 172_N 1.263 0.96
61_A 84_Q 1.25 0.96
112_M 141_F 1.244 0.96
151_S 154_S 1.238 0.96
159_K 175_T 1.235 0.96
92_G 118_R 1.219 0.95
55_P 89_M 1.219 0.95
201_I 205_T 1.218 0.95
120_I 134_L 1.216 0.95
217_P 221_Y 1.211 0.95
168_A 208_P 1.205 0.95
67_D 71_N 1.2 0.95
165_S 170_T 1.184 0.94
63_S 94_V 1.183 0.94
155_P 158_H 1.183 0.94
165_S 168_A 1.177 0.94
114_Y 118_R 1.14 0.92
94_V 117_V 1.137 0.92
98_G 142_W 1.135 0.92
79_V 96_V 1.129 0.92
59_Y 118_R 1.124 0.92
98_G 104_K 1.121 0.92
65_I 75_S 1.113 0.91
238_N 241_Q 1.109 0.91
163_T 170_T 1.096 0.90
181_I 201_I 1.088 0.90
128_N 137_R 1.076 0.89
117_V 138_I 1.074 0.89
58_P 122_P 1.074 0.89
54_D 119_E 1.07 0.89
162_L 171_V 1.066 0.89
221_Y 229_M 1.065 0.89
63_S 117_V 1.06 0.88
86_I 91_N 1.06 0.88
93_Q 135_Q 1.052 0.88
92_G 119_E 1.051 0.88
116_N 135_Q 1.011 0.85
110_E 143_R 1.008 0.85
60_L 177_Y 1.005 0.84
171_V 181_I 1.003 0.84
119_E 133_A 1.002 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2xg5A10.8641000.208Contact Map0.792
4djmA80.8721000.237Contact Map0.815
1klfA80.81000.247Contact Map0.776
3gfuC20.8441000.247Contact Map0.7
2co7B10.8441000.248Contact Map0.715
4ay0A20.8481000.256Contact Map0.762
1l4iA20.7961000.257Contact Map0.766
3q48A20.9561000.269Contact Map0.8
1mspA20.44842.80.953Contact Map0.571
1m1sA10.45220.80.96Contact Map0.593
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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