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OPENSEQ.org
ECPD - Chaperone protein EcpD
UniProt: P33128 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11973
Length: 246 (221)
Sequences: 1359
Seq/Len: 6.15
ECPD
Paralog alert: 0.90 [within 20: 0.52] - ratio of genomes with paralogs
Cluster includes: ECPD ELFD FIMC SFMC YBGP YCBF YEHC YFCS YHCA YQIH YRAI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
104_L 112_F 2.958 1.00
186_S 205_M 2.91 1.00
29_I 142_I 2.893 1.00
184_Y 207_A 2.804 1.00
111_V 205_M 2.692 1.00
207_A 210_S 2.636 1.00
37_K 40_Q 2.601 1.00
108_R 209_F 2.6 1.00
145_F 205_M 2.525 1.00
34_V 114_F 2.34 1.00
178_T 211_D 2.333 1.00
34_V 43_V 2.295 1.00
61_L 144_L 2.234 1.00
34_V 96_L 2.193 1.00
60_W 115_N 2.161 1.00
62_D 141_R 2.15 1.00
163_K 178_T 2.111 1.00
55_L 118_E 2.104 1.00
177_V 214_M 2.047 1.00
54_P 85_R 2.04 1.00
54_P 87_D 2.029 1.00
105_P 110_S 2.01 1.00
38_S 106_K 1.914 1.00
115_N 141_R 1.857 1.00
234_N 240_I 1.829 1.00
111_V 186_S 1.776 1.00
151_L 183_Y 1.746 1.00
117_L 139_R 1.713 1.00
164_W 177_V 1.682 1.00
155_P 158_A 1.668 1.00
77_F 96_L 1.667 1.00
161_A 181_T 1.637 1.00
62_D 115_N 1.633 1.00
39_D 149_D 1.629 1.00
105_P 108_R 1.581 0.99
87_D 90_R 1.572 0.99
206_I 212_E 1.536 0.99
157_E 160_L 1.533 0.99
176_R 213_V 1.528 0.99
37_K 43_V 1.521 0.99
162_L 177_V 1.506 0.99
29_I 116_V 1.489 0.99
27_I 86_I 1.464 0.99
96_L 144_L 1.439 0.99
79_A 94_I 1.423 0.99
186_S 232_A 1.418 0.98
167_S 176_R 1.388 0.98
185_V 232_A 1.385 0.98
158_A 185_V 1.37 0.98
34_V 142_I 1.359 0.98
28_V 31_G 1.356 0.98
165_F 176_R 1.356 0.98
234_N 238_G 1.346 0.98
145_F 184_Y 1.336 0.98
46_R 91_G 1.324 0.97
47_L 57_V 1.311 0.97
111_V 145_F 1.3 0.97
176_R 211_D 1.293 0.97
62_D 113_W 1.293 0.97
29_I 45_V 1.29 0.97
113_W 117_L 1.284 0.97
79_A 114_F 1.278 0.97
94_I 114_F 1.254 0.96
79_A 96_L 1.25 0.96
119_V 138_F 1.242 0.96
164_W 190_G 1.235 0.96
36_Y 43_V 1.226 0.95
92_Q 117_L 1.223 0.95
54_P 121_P 1.22 0.95
26_D 118_E 1.218 0.95
206_I 210_S 1.205 0.95
232_A 240_I 1.187 0.94
59_S 116_V 1.175 0.94
57_V 84_S 1.167 0.93
94_I 116_V 1.165 0.93
132_S 141_R 1.147 0.93
153_G 157_E 1.115 0.91
98_Y 146_Y 1.105 0.91
56_L 117_L 1.101 0.91
98_Y 103_S 1.094 0.90
109_E 147_R 1.075 0.89
98_Y 102_T 1.068 0.89
187_F 206_I 1.068 0.89
165_F 178_T 1.061 0.88
52_N 89_K 1.056 0.88
56_L 183_Y 1.056 0.88
92_Q 118_E 1.045 0.87
63_T 72_S 1.043 0.87
60_W 141_R 1.043 0.87
59_S 94_I 1.041 0.87
228_V 232_A 1.037 0.87
164_W 205_M 1.034 0.87
86_I 91_G 1.03 0.86
62_D 70_P 1.028 0.86
168_G 171_G 1.022 0.86
84_S 92_Q 1.01 0.85
63_T 71_G 1.004 0.84
118_E 137_A 1.003 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4djmA80.90651000.218Contact Map0.815
1klfA80.81711000.23Contact Map0.781
2co7B10.8781000.232Contact Map0.727
4ay0A20.8741000.234Contact Map0.779
1l4iA20.82111000.235Contact Map0.778
3q48A20.96341000.236Contact Map0.788
2xg5A10.82111000.239Contact Map0.803
3gfuC20.80081000.249Contact Map0.704
1mspA20.471558.90.946Contact Map0.6
1z9lA10.4675280.956Contact Map0.682
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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