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OPENSEQ.org
YHCA - Uncharacterized fimbrial chaperone YhcA
UniProt: P28722 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11515
Length: 224 (211)
Sequences: 1393
Seq/Len: 6.60
YHCA
Paralog alert: 0.90 [within 20: 0.52] - ratio of genomes with paralogs
Cluster includes: ECPD ELFD FIMC SFMC YBGP YCBF YEHC YFCS YHCA YQIH YRAI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
24_P 126_L 2.953 1.00
93_V 101_K 2.811 1.00
165_R 185_Y 2.81 1.00
163_V 187_L 2.803 1.00
100_L 185_Y 2.743 1.00
129_L 185_Y 2.575 1.00
187_L 190_T 2.569 1.00
97_S 189_H 2.465 1.00
32_D 35_R 2.464 1.00
157_S 191_S 2.364 1.00
146_E 157_S 2.326 1.00
56_I 128_V 2.284 1.00
50_S 107_G 2.206 1.00
49_P 76_R 2.203 1.00
29_L 38_A 2.192 1.00
29_L 87_F 2.168 1.00
29_L 103_V 2.157 1.00
57_V 125_D 2.112 1.00
55_T 104_T 2.104 1.00
49_P 78_E 2.09 1.00
156_I 194_T 2.042 1.00
33_E 95_L 1.98 1.00
94_P 99_E 1.93 1.00
104_T 125_D 1.853 1.00
138_E 141_T 1.767 1.00
135_L 162_Y 1.76 1.00
140_E 143_K 1.74 1.00
68_L 87_F 1.719 1.00
100_L 165_R 1.718 1.00
147_W 156_I 1.705 1.00
106_E 123_R 1.705 1.00
94_P 97_S 1.647 1.00
57_V 104_T 1.619 1.00
144_F 160_S 1.592 1.00
78_E 81_Q 1.585 1.00
155_E 193_T 1.571 0.99
148_R 155_E 1.546 0.99
87_F 128_V 1.536 0.99
34_K 133_A 1.535 0.99
141_T 164_V 1.508 0.99
32_D 38_A 1.508 0.99
186_F 192_T 1.5 0.99
23_V 26_T 1.459 0.99
164_V 208_P 1.406 0.99
129_L 163_V 1.4 0.99
145_L 156_I 1.394 0.99
150_N 155_E 1.392 0.98
155_E 191_S 1.39 0.98
165_R 208_P 1.372 0.98
24_P 40_I 1.358 0.98
210_S 214_Y 1.355 0.98
150_N 153_Q 1.348 0.98
41_N 82_V 1.338 0.98
42_I 52_L 1.334 0.98
24_P 105_F 1.31 0.98
70_P 85_V 1.308 0.98
83_Q 106_E 1.291 0.97
210_S 216_G 1.269 0.97
52_L 75_I 1.267 0.97
70_P 103_V 1.26 0.97
85_V 103_V 1.242 0.96
57_V 102_R 1.236 0.96
22_M 77_V 1.235 0.96
21_G 107_G 1.235 0.96
29_L 126_L 1.229 0.96
31_V 38_A 1.215 0.96
47_D 80_G 1.201 0.95
100_L 129_L 1.195 0.95
54_T 105_F 1.192 0.95
49_P 110_P 1.187 0.95
70_P 87_F 1.181 0.95
102_R 106_E 1.176 0.95
175_S 178_T 1.174 0.94
186_F 190_T 1.155 0.94
153_Q 193_T 1.155 0.94
89_L 130_I 1.148 0.94
108_I 122_I 1.138 0.93
141_T 208_P 1.119 0.92
85_V 105_F 1.119 0.92
166_M 186_F 1.114 0.92
148_R 157_S 1.1 0.92
83_Q 107_G 1.086 0.91
50_S 106_E 1.08 0.91
208_P 216_G 1.078 0.90
77_V 82_V 1.073 0.90
142_W 206_F 1.054 0.89
145_L 166_M 1.033 0.88
55_T 125_D 1.032 0.88
168_L 207_Y 1.032 0.88
210_S 213_G 1.031 0.88
46_D 50_S 1.027 0.87
54_T 85_V 1.017 0.87
75_I 83_Q 1.006 0.86
28_V 127_P 1 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4djmA80.97771000.144Contact Map0.828
2co7B10.9421000.154Contact Map0.756
1klfA80.88391000.156Contact Map0.811
1l4iA20.88391000.158Contact Map0.796
4ay0A20.9421000.166Contact Map0.786
2xg5A10.89291000.176Contact Map0.825
3gfuC20.87051000.185Contact Map0.733
3q48A20.98661000.195Contact Map0.823
1mspA20.491154.80.944Contact Map0.565
2ys4A10.482123.30.954Contact Map0.414
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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