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OPENSEQ.org

PGMB - Beta-phosphoglucomutase
UniProt: P77366 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13918
Length: 219 (206)
Sequences: 11832
Seq/Len: 57.44

PGMB
Paralog alert: 0.91 [within 20: 0.14] - ratio of genomes with paralogs
Cluster includes: GPH PGMB YFBT YIEH YIGB YIHX YJJG YNIC YQAB YRFG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
4_Q 166_A 4.117 1.00
155_A 159_G 3.01 1.00
180_I 187_S 2.94 1.00
171_E 176_G 2.922 1.00
126_A 131_R 2.84 1.00
145_N 149_D 2.677 1.00
5_G 162_V 2.515 1.00
103_A 133_F 2.471 1.00
157_C 167_C 2.425 1.00
155_A 158_A 2.396 1.00
111_S 135_T 2.335 1.00
99_R 103_A 2.234 1.00
181_N 198_Q 2.156 1.00
106_R 135_T 2.133 1.00
116_S 121_A 2.117 1.00
31_E 77_R 2.086 1.00
177_I 187_S 2.073 1.00
178_D 182_A 2.067 1.00
3_L 186_R 2.044 1.00
115_A 152_I 1.999 1.00
168_I 188_V 1.975 1.00
202_P 206_S 1.966 1.00
8_F 112_V 1.962 1.00
157_C 185_M 1.956 1.00
113_G 136_F 1.948 1.00
145_N 151_E 1.924 1.00
163_P 166_A 1.882 1.00
136_F 159_G 1.783 1.00
98_I 204_T 1.726 1.00
7_I 115_A 1.721 1.00
106_R 133_F 1.702 1.00
112_V 134_F 1.688 1.00
169_G 180_I 1.681 1.00
6_V 110_I 1.662 1.00
157_C 164_P 1.632 1.00
27_Q 81_L 1.632 1.00
6_V 170_I 1.58 1.00
5_G 160_L 1.576 1.00
37_D 40_F 1.567 1.00
162_V 167_C 1.566 1.00
104_D 108_Q 1.498 1.00
113_G 160_L 1.498 1.00
186_R 198_Q 1.497 1.00
7_I 156_A 1.464 1.00
6_V 105_L 1.439 1.00
191_G 202_P 1.438 1.00
67_N 70_E 1.412 1.00
13_V 170_I 1.402 0.99
174_Q 178_D 1.38 0.99
51_E 54_R 1.365 0.99
10_L 121_A 1.358 0.99
14_I 98_I 1.323 0.99
122_P 131_R 1.317 0.99
27_Q 31_E 1.307 0.99
31_E 81_L 1.304 0.99
94_V 130_L 1.303 0.99
97_G 100_S 1.29 0.99
167_C 185_M 1.285 0.99
10_L 15_T 1.282 0.99
138_A 159_G 1.269 0.99
7_I 169_G 1.262 0.99
32_I 77_R 1.234 0.98
81_L 84_H 1.222 0.98
203_S 206_S 1.22 0.98
150_P 154_L 1.218 0.98
177_I 189_G 1.211 0.98
5_G 167_C 1.209 0.98
153_F 169_G 1.204 0.98
70_E 73_Q 1.204 0.98
7_I 167_C 1.2 0.98
153_F 185_M 1.197 0.98
104_D 107_A 1.191 0.98
138_A 156_A 1.184 0.98
115_A 156_A 1.179 0.98
181_N 187_S 1.163 0.97
27_Q 85_S 1.153 0.97
103_A 107_A 1.139 0.97
77_R 80_L 1.138 0.97
104_D 208_T 1.129 0.97
188_V 201_L 1.127 0.97
77_R 81_L 1.115 0.96
28_I 32_I 1.11 0.96
114_L 134_F 1.106 0.96
10_L 114_L 1.106 0.96
76_Y 80_L 1.105 0.96
73_Q 77_R 1.104 0.96
105_L 110_I 1.1 0.96
121_A 139_D 1.096 0.96
151_E 155_A 1.087 0.96
11_D 17_T 1.084 0.96
116_S 139_D 1.076 0.95
23_Q 27_Q 1.075 0.95
122_P 126_A 1.068 0.95
100_S 103_A 1.064 0.95
169_G 185_M 1.06 0.95
3_L 168_I 1.058 0.95
153_F 171_E 1.055 0.95
5_G 111_S 1.049 0.94
144_K 151_E 1.049 0.94
94_V 99_R 1.038 0.94
23_Q 26_Q 1.02 0.93
175_A 178_D 1.011 0.93
7_I 160_L 1.007 0.93
136_F 160_L 1.005 0.93
191_G 200_L 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4g9bA111000.24Contact Map0.8
3nasA20.98631000.244Contact Map0.773
4gibA20.99091000.257Contact Map0.82
2wf7A10.98631000.276Contact Map0.793
3iruA20.97721000.279Contact Map0.742
4eekA10.95431000.281Contact Map0.77
3qxgA20.95431000.283Contact Map0.862
1swvA20.97721000.284Contact Map0.819
3dv9A10.96351000.286Contact Map0.82
3s6jA60.97261000.286Contact Map0.723

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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