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OPENSEQ.org

YNIC - 2-deoxyglucose-6-phosphate phosphatase
UniProt: P77247 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13988
Length: 222 (211)
Sequences: 12341
Seq/Len: 58.49

YNIC
Paralog alert: 0.91 [within 20: 0.14] - ratio of genomes with paralogs
Cluster includes: GPH PGMB YFBT YIEH YIGB YIHX YJJG YNIC YQAB YRFG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
8_L 167_T 4.064 1.00
172_E 177_G 3.122 1.00
156_D 160_K 2.897 1.00
181_S 188_S 2.872 1.00
127_T 132_R 2.705 1.00
146_Y 150_H 2.611 1.00
182_K 206_D 2.496 1.00
119_L 123_E 2.48 1.00
102_A 134_S 2.452 1.00
9_A 163_V 2.429 1.00
158_A 168_C 2.375 1.00
156_D 159_A 2.368 1.00
115_S 122_L 2.301 1.00
110_L 136_D 2.259 1.00
98_R 102_A 2.158 1.00
210_S 214_E 2.112 1.00
35_S 78_R 2.092 1.00
105_K 136_D 2.083 1.00
119_L 143_K 2.075 1.00
178_M 188_S 2.052 1.00
7_I 187_R 2.045 1.00
179_I 183_A 2.007 1.00
114_A 153_V 1.963 1.00
146_Y 152_Q 1.942 1.00
158_A 186_M 1.94 1.00
169_V 189_I 1.94 1.00
112_G 137_A 1.912 1.00
12_F 111_V 1.899 1.00
164_D 167_T 1.871 1.00
11_I 114_A 1.789 1.00
137_A 160_K 1.787 1.00
187_R 206_D 1.73 1.00
111_V 135_F 1.699 1.00
31_D 82_R 1.698 1.00
97_V 212_L 1.679 1.00
10_A 109_L 1.662 1.00
158_A 165_P 1.643 1.00
105_K 134_S 1.629 1.00
170_A 181_S 1.608 1.00
9_A 161_L 1.545 1.00
10_A 171_L 1.54 1.00
163_V 168_C 1.522 1.00
11_I 157_C 1.482 1.00
103_L 107_Q 1.474 1.00
192_P 210_S 1.453 1.00
112_G 161_L 1.421 1.00
175_V 179_I 1.404 0.99
96_G 99_E 1.378 0.99
189_I 209_L 1.371 0.99
56_M 59_D 1.369 0.99
10_A 104_C 1.362 0.99
14_M 122_L 1.344 0.99
14_M 19_I 1.34 0.99
211_S 214_E 1.339 0.99
35_S 82_R 1.322 0.99
123_E 132_R 1.309 0.99
18_L 97_V 1.274 0.99
168_C 186_M 1.268 0.99
36_L 78_R 1.263 0.99
17_L 171_L 1.262 0.99
82_R 85_S 1.255 0.99
78_R 82_R 1.246 0.98
11_I 170_A 1.241 0.98
71_S 74_E 1.238 0.98
9_A 168_C 1.232 0.98
93_L 131_L 1.222 0.98
139_A 160_K 1.206 0.98
31_D 35_S 1.206 0.98
151_P 155_L 1.204 0.98
122_L 140_S 1.198 0.98
77_E 81_A 1.189 0.98
154_Y 170_A 1.174 0.98
11_I 168_C 1.172 0.98
103_L 106_E 1.162 0.97
154_Y 186_M 1.16 0.97
139_A 157_C 1.153 0.97
114_A 157_C 1.146 0.97
99_E 213_T 1.14 0.97
115_S 140_S 1.133 0.97
189_I 207_V 1.123 0.97
152_Q 156_D 1.122 0.97
94_L 193_A 1.121 0.97
154_Y 172_E 1.116 0.96
102_A 106_E 1.103 0.96
15_D 21_S 1.087 0.96
113_L 135_F 1.083 0.96
123_E 127_T 1.078 0.95
32_V 36_L 1.072 0.95
182_K 188_S 1.07 0.95
100_A 212_L 1.066 0.95
14_M 113_L 1.055 0.95
178_M 190_V 1.045 0.94
192_P 208_K 1.044 0.94
74_E 78_R 1.044 0.94
137_A 161_L 1.044 0.94
7_I 169_V 1.043 0.94
170_A 186_M 1.042 0.94
104_C 109_L 1.038 0.94
78_R 81_A 1.038 0.94
99_E 102_A 1.029 0.94
27_R 31_D 1.024 0.93
93_L 98_R 1.019 0.93
178_M 205_A 1.002 0.92
9_A 110_L 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1te2A211000.247Contact Map0.869
4eekA10.9731000.265Contact Map0.774
4gibA20.9641000.273Contact Map0.794
1swvA20.9821000.278Contact Map0.82
3l5kA10.97751000.279Contact Map0.784
3nasA20.94141000.281Contact Map0.752
3iruA20.98651000.282Contact Map0.702
3d6jA10.97751000.283Contact Map0.861
3s6jA60.97751000.284Contact Map0.72
4g9bA10.94591000.286Contact Map0.788

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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