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OPENSEQ.org

YRFG - GMP/IMP nucleotidase YrfG
UniProt: P64636 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12928
Length: 222 (210)
Sequences: 11884
Seq/Len: 56.59

YRFG
Paralog alert: 0.93 [within 20: 0.22] - ratio of genomes with paralogs
Cluster includes: GPH PGMB YFBT YIEH YIGB YIHX YJJG YNIC YQAB YRFG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
11_D 168_R 4.352 1.00
173_D 178_I 3.344 1.00
128_E 133_D 2.978 1.00
157_A 161_A 2.964 1.00
147_Y 151_D 2.643 1.00
12_T 164_L 2.571 1.00
120_P 124_A 2.559 1.00
183_A 208_H 2.522 1.00
103_E 135_H 2.519 1.00
111_Q 137_D 2.493 1.00
157_A 160_E 2.48 1.00
116_T 123_L 2.459 1.00
182_A 190_C 2.391 1.00
159_A 169_T 2.354 1.00
99_I 103_E 2.352 1.00
120_P 144_T 2.337 1.00
212_N 216_R 2.189 1.00
106_K 137_D 2.16 1.00
115_L 154_L 2.093 1.00
10_V 188_R 2.052 1.00
180_D 184_Q 2.05 1.00
159_A 187_I 2.046 1.00
113_I 138_L 2.031 1.00
15_L 112_R 1.918 1.00
165_K 168_R 1.907 1.00
147_Y 153_R 1.899 1.00
138_L 161_A 1.893 1.00
14_L 115_L 1.863 1.00
98_T 214_Y 1.757 1.00
13_V 110_K 1.755 1.00
171_F 182_A 1.729 1.00
106_K 135_H 1.721 1.00
112_R 136_L 1.717 1.00
179_L 190_C 1.688 1.00
188_R 208_H 1.684 1.00
13_V 172_I 1.673 1.00
159_A 166_A 1.603 1.00
164_L 169_T 1.595 1.00
104_A 108_S 1.582 1.00
12_T 162_T 1.578 1.00
14_L 158_V 1.568 1.00
13_V 105_L 1.539 1.00
113_I 162_T 1.524 1.00
213_D 216_R 1.52 1.00
104_A 218_I 1.486 1.00
194_T 212_N 1.481 1.00
176_E 180_D 1.481 1.00
68_Y 71_D 1.407 0.99
97_D 100_P 1.404 0.99
17_M 22_L 1.399 0.99
169_T 187_I 1.355 0.99
20_T 172_I 1.353 0.99
124_A 133_D 1.343 0.99
170_L 191_L 1.337 0.99
21_L 98_T 1.329 0.99
12_T 169_T 1.278 0.99
104_A 107_A 1.277 0.99
140_L 158_V 1.274 0.99
123_L 141_S 1.266 0.99
17_M 123_L 1.257 0.99
140_L 161_A 1.257 0.99
182_A 189_Y 1.253 0.99
101_F 214_Y 1.241 0.98
103_E 107_A 1.23 0.98
114_L 136_L 1.228 0.98
152_Q 156_H 1.21 0.98
94_L 132_L 1.203 0.98
17_M 114_L 1.199 0.98
155_W 173_D 1.198 0.98
14_L 169_T 1.197 0.98
38_T 42_K 1.189 0.98
124_A 128_E 1.183 0.98
14_L 171_F 1.162 0.97
100_P 215_R 1.158 0.97
106_K 112_R 1.152 0.97
18_D 24_L 1.151 0.97
101_F 218_I 1.15 0.97
179_L 192_G 1.147 0.97
153_R 157_A 1.145 0.97
155_W 187_I 1.127 0.97
155_W 171_F 1.126 0.97
177_A 180_D 1.124 0.97
94_L 99_I 1.116 0.96
146_G 153_R 1.088 0.96
131_G 134_A 1.078 0.95
105_L 110_K 1.077 0.95
116_T 141_S 1.075 0.95
211_L 217_L 1.075 0.95
171_F 187_I 1.068 0.95
39_W 43_N 1.06 0.95
100_P 103_E 1.06 0.95
37_E 41_A 1.05 0.94
199_G 203_K 1.048 0.94
181_A 185_F 1.043 0.94
14_L 162_T 1.043 0.94
138_L 162_T 1.04 0.94
179_L 207_R 1.035 0.94
120_P 141_S 1.035 0.94
12_T 111_Q 1.03 0.94
38_T 41_A 1.026 0.94
42_K 84_M 1.016 0.93
156_H 160_E 1.015 0.93
10_V 170_L 1.011 0.93
125_V 129_H 1.008 0.93
115_L 158_V 1.003 0.93
194_T 210_S 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4eekA10.9551000.295Contact Map0.755
2om6A20.94591000.3Contact Map0.823
3s6jA60.93241000.304Contact Map0.715
1te2A20.95051000.306Contact Map0.856
3l5kA10.94591000.311Contact Map0.774
3umbA10.94591000.314Contact Map0.775
1swvA20.93691000.315Contact Map0.812
3qxgA20.94591000.321Contact Map0.802
3iruA20.95051000.321Contact Map0.698
2pibA20.90541000.321Contact Map0.836

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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