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OPENSEQ.org

YIEH - 6-phosphogluconate phosphatase
UniProt: P31467 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11725
Length: 221 (211)
Sequences: 12878
Seq/Len: 61.03

YIEH
Paralog alert: 0.91 [within 20: 0.22] - ratio of genomes with paralogs
Cluster includes: GPH PGMB YFBT YIEH YIGB YIHX YJJG YNIC YQAB YRFG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
5_E 161_N 4.2 1.00
166_D 171_G 3.346 1.00
150_H 154_A 2.841 1.00
120_G 125_L 2.786 1.00
175_G 182_V 2.784 1.00
140_R 144_D 2.613 1.00
112_N 116_Q 2.555 1.00
98_S 127_Y 2.464 1.00
6_A 157_V 2.457 1.00
108_S 115_M 2.421 1.00
152_A 162_C 2.392 1.00
176_I 199_V 2.39 1.00
150_H 153_K 2.35 1.00
103_P 129_P 2.298 1.00
32_E 74_V 2.288 1.00
94_G 98_S 2.235 1.00
112_N 137_D 2.162 1.00
107_V 147_L 2.059 1.00
172_A 182_V 2.032 1.00
203_T 207_Q 2.026 1.00
173_Q 177_D 1.986 1.00
4_I 181_E 1.981 1.00
101_T 129_P 1.949 1.00
163_I 183_F 1.941 1.00
152_A 180_M 1.927 1.00
9_F 104_M 1.888 1.00
140_R 146_A 1.878 1.00
158_N 161_N 1.834 1.00
8_F 107_V 1.784 1.00
7_V 102_A 1.743 1.00
28_T 78_E 1.73 1.00
93_A 205_L 1.707 1.00
101_T 127_Y 1.696 1.00
104_M 128_F 1.692 1.00
105_C 130_D 1.662 1.00
152_A 159_V 1.616 1.00
164_L 175_G 1.596 1.00
181_E 199_V 1.595 1.00
6_A 155_M 1.549 1.00
7_V 165_V 1.54 1.00
105_C 155_M 1.531 1.00
8_F 151_A 1.53 1.00
157_V 162_C 1.499 1.00
186_C 203_T 1.47 1.00
204_H 207_Q 1.462 1.00
99_A 209_P 1.444 1.00
7_V 100_I 1.426 1.00
92_G 95_A 1.425 1.00
130_D 154_A 1.399 0.99
67_A 70_E 1.391 0.99
11_C 16_V 1.389 0.99
183_F 202_F 1.365 0.99
162_C 180_M 1.348 0.99
116_Q 125_L 1.327 0.99
169_V 173_Q 1.314 0.99
8_F 164_L 1.312 0.99
53_E 56_D 1.299 0.99
14_T 165_V 1.294 0.99
6_A 162_C 1.292 0.99
11_C 115_M 1.284 0.99
130_D 133_F 1.281 0.99
32_E 78_E 1.278 0.99
15_L 93_A 1.258 0.99
33_F 74_V 1.238 0.98
145_P 149_F 1.215 0.98
8_F 162_C 1.21 0.98
200_T 211_L 1.205 0.98
28_T 32_E 1.201 0.98
183_F 200_T 1.192 0.98
148_M 180_M 1.187 0.98
106_V 128_F 1.181 0.98
116_Q 120_G 1.175 0.98
148_M 164_L 1.165 0.97
11_C 106_V 1.161 0.97
73_H 77_A 1.153 0.97
78_E 81_R 1.153 0.97
95_A 206_S 1.139 0.97
96_L 205_L 1.132 0.97
176_I 182_V 1.128 0.97
89_A 124_M 1.126 0.97
101_T 104_M 1.125 0.97
12_D 18_S 1.123 0.97
96_L 209_P 1.112 0.96
28_T 82_L 1.105 0.96
4_I 163_I 1.101 0.96
107_V 151_A 1.096 0.96
148_M 166_D 1.094 0.96
146_A 150_H 1.091 0.96
24_R 28_T 1.073 0.95
95_A 98_S 1.059 0.95
186_C 201_T 1.051 0.94
133_F 154_A 1.05 0.94
6_A 103_P 1.037 0.94
202_F 208_L 1.034 0.94
74_V 77_A 1.032 0.94
56_D 60_L 1.032 0.94
133_F 151_A 1.031 0.94
29_M 33_F 1.03 0.94
89_A 94_G 1.027 0.94
174_S 178_A 1.025 0.93
164_L 180_M 1.024 0.93
24_R 82_L 1.023 0.93
149_F 153_K 1.019 0.93
90_I 187_A 1.011 0.93
74_V 78_E 1.007 0.93
165_V 183_F 1.005 0.93
172_A 184_Y 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4eekA10.9911000.255Contact Map0.802
1te2A20.97291000.265Contact Map0.86
2fdrA10.9911000.267Contact Map0.76
3l5kA10.97741000.274Contact Map0.765
3d6jA10.98191000.281Contact Map0.863
1swvA20.9911000.283Contact Map0.821
2hi0A20.95931000.286Contact Map0.805
4ex6A10.97291000.286Contact Map0.762
3iruA20.9911000.287Contact Map0.713
3qxgA20.95931000.288Contact Map0.816

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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