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OPENSEQ.org

YJJG - Pyrimidine 5'-nucleotidase YjjG
UniProt: P0A8Y1 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12115
Length: 225 (221)
Sequences: 12624
Seq/Len: 57.12

YJJG
Paralog alert: 0.93 [within 20: 0.24] - ratio of genomes with paralogs
Cluster includes: GPH PGMB YFBT YIEH YIGB YIHX YJJG YNIC YQAB YRFG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
4_D 170_R 4.346 1.00
175_G 181_D 3.195 1.00
158_Y 162_Q 3.006 1.00
185_G 192_T 2.917 1.00
129_E 134_R 2.825 1.00
148_V 152_N 2.675 1.00
105_N 136_Y 2.573 1.00
112_K 138_D 2.566 1.00
121_S 125_Q 2.563 1.00
160_L 171_V 2.465 1.00
186_I 209_T 2.444 1.00
158_Y 161_E 2.427 1.00
117_T 124_Q 2.377 1.00
101_V 105_N 2.372 1.00
5_W 166_P 2.36 1.00
108_R 138_D 2.227 1.00
121_S 145_E 2.213 1.00
114_G 139_L 2.136 1.00
213_S 217_E 2.121 1.00
160_L 190_L 2.067 1.00
116_I 155_I 2.065 1.00
172_L 193_C 2.007 1.00
182_I 192_T 2 1.00
3_W 191_A 2 1.00
139_L 162_Q 1.996 1.00
183_L 187_N 1.97 1.00
148_V 154_K 1.956 1.00
167_D 170_R 1.945 1.00
8_F 113_I 1.932 1.00
7_F 116_I 1.886 1.00
191_A 209_T 1.868 1.00
6_I 111_A 1.831 1.00
160_L 168_R 1.816 1.00
113_I 137_F 1.805 1.00
108_R 136_Y 1.754 1.00
100_A 215_L 1.71 1.00
29_D 85_A 1.63 1.00
5_W 163_A 1.623 1.00
173_M 185_G 1.607 1.00
7_F 159_A 1.583 1.00
166_P 171_V 1.582 1.00
6_I 174_V 1.568 1.00
196_N 213_S 1.558 1.00
106_A 219_E 1.556 1.00
6_I 107_I 1.552 1.00
114_G 163_A 1.527 1.00
214_S 217_E 1.526 1.00
193_C 212_V 1.462 1.00
7_F 173_M 1.443 1.00
10_A 15_F 1.44 1.00
99_G 102_S 1.42 1.00
35_T 38_D 1.413 1.00
171_V 190_L 1.391 0.99
141_V 159_A 1.388 0.99
25_R 29_D 1.387 0.99
141_V 162_Q 1.381 0.99
13_T 174_V 1.339 0.99
25_R 85_A 1.323 0.99
10_A 115_I 1.321 0.99
125_Q 134_R 1.303 0.99
103_L 219_E 1.291 0.99
5_W 171_V 1.285 0.99
115_I 137_F 1.284 0.99
106_A 109_G 1.28 0.99
14_L 100_A 1.278 0.99
153_K 157_D 1.261 0.99
7_F 171_V 1.247 0.99
59_T 62_Q 1.244 0.98
193_C 210_W 1.232 0.98
210_W 221_L 1.21 0.98
186_I 192_T 1.202 0.98
96_P 133_L 1.193 0.98
103_L 215_L 1.192 0.98
83_N 87_I 1.188 0.98
105_N 109_G 1.183 0.98
125_Q 129_E 1.183 0.98
102_S 216_H 1.168 0.97
139_L 163_A 1.163 0.97
10_A 124_Q 1.162 0.97
26_M 30_Y 1.152 0.97
117_T 142_I 1.151 0.97
5_W 112_K 1.15 0.97
156_F 190_L 1.146 0.97
121_S 142_I 1.131 0.97
97_L 197_A 1.125 0.97
196_N 211_T 1.124 0.97
156_F 173_M 1.122 0.97
96_P 101_V 1.113 0.96
212_V 218_L 1.112 0.96
124_Q 142_I 1.106 0.96
156_F 175_G 1.099 0.96
107_I 111_A 1.093 0.96
147_G 154_K 1.093 0.96
25_R 89_A 1.09 0.96
116_I 159_A 1.089 0.96
85_A 89_A 1.087 0.96
102_S 105_N 1.086 0.96
174_V 193_C 1.082 0.96
25_R 28_L 1.071 0.95
182_I 194_W 1.067 0.95
3_W 172_L 1.061 0.95
157_D 161_E 1.059 0.95
154_K 158_Y 1.057 0.95
85_A 88_N 1.056 0.95
108_R 113_I 1.054 0.95
173_M 190_L 1.047 0.94
178_A 183_L 1.045 0.94
132_G 135_D 1.045 0.94
184_G 188_A 1.043 0.94
104_L 136_Y 1.012 0.93
180_S 183_L 1.003 0.93
11_D 17_F 1.002 0.92
81_K 85_A 1.001 0.92
157_D 188_A 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qnmA10.99111000.224Contact Map0.849
3ed5A111000.225Contact Map0.787
4eekA10.91111000.258Contact Map0.776
1swvA20.95561000.267Contact Map0.83
2om6A20.97781000.267Contact Map0.845
3smvA10.97331000.274Contact Map0.7
3umcA40.97781000.274Contact Map0.809
2hdoA10.88441000.275Contact Map0.842
3umbA10.97781000.278Contact Map0.793
3iruA20.95561000.279Contact Map0.725

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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