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MHPC - 2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase
UniProt: P77044 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG20275
Length: 288 (273)
Sequences: 21669
Seq/Len: 79.37
MHPC
Paralog alert: 0.83 [within 20: 0.25] - ratio of genomes with paralogs
Cluster includes: BIOH DLHH MENH MHPC PLDB RUTD YBFF YCJY YFHR YGHX YJFP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
109_H 133_K 4.387 1.00
30_D 67_R 4.269 1.00
74_P 95_I 3.897 1.00
237_R 263_R 3.176 1.00
273_H 276_A 2.853 1.00
232_L 284_F 2.846 1.00
57_N 278_N 2.78 1.00
107_K 132_G 2.76 1.00
97_K 123_F 2.741 1.00
260_H 280_L 2.684 1.00
137_M 277_F 2.602 1.00
109_H 132_G 2.569 1.00
101_D 130_R 2.526 1.00
100_V 108_I 2.334 1.00
262_F 280_L 2.281 1.00
65_G 282_L 2.271 1.00
138_G 239_D 2.199 1.00
25_R 80_D 2.181 1.00
97_K 127_W 2.181 1.00
258_E 287_R 2.15 1.00
251_L 257_S 2.121 1.00
94_R 126_K 2.1 1.00
123_F 127_W 2.082 1.00
237_R 261_I 2.04 1.00
265_C 273_H 2.012 1.00
28_F 99_V 1.982 1.00
117_G 139_G 1.98 1.00
97_K 101_D 1.971 1.00
135_V 281_V 1.969 1.00
97_K 130_R 1.967 1.00
110_L 120_S 1.951 1.00
124_T 134_L 1.901 1.00
120_S 134_L 1.862 1.00
27_H 78_K 1.847 1.00
109_H 135_V 1.834 1.00
122_A 126_K 1.827 1.00
109_H 285_L 1.815 1.00
231_T 254_I 1.785 1.00
71_L 96_L 1.777 1.00
37_T 69_I 1.759 1.00
244_M 261_I 1.736 1.00
61_L 278_N 1.674 1.00
280_L 283_N 1.673 1.00
30_D 69_I 1.669 1.00
96_L 123_F 1.651 1.00
69_I 99_V 1.649 1.00
279_Q 283_N 1.639 1.00
31_C 70_L 1.636 1.00
41_L 120_S 1.636 1.00
41_L 96_L 1.634 1.00
41_L 73_C 1.623 1.00
37_T 67_R 1.611 1.00
40_L 111_L 1.583 1.00
42_H 76_W 1.581 1.00
249_R 253_G 1.578 1.00
90_D 126_K 1.55 1.00
73_C 119_S 1.546 1.00
127_W 130_R 1.536 1.00
223_R 226_E 1.524 1.00
262_F 265_C 1.5 1.00
123_F 131_V 1.496 1.00
276_A 280_L 1.485 1.00
93_A 122_A 1.476 1.00
40_L 68_V 1.471 1.00
39_V 100_V 1.457 1.00
100_V 105_I 1.453 1.00
66_Y 109_H 1.44 1.00
16_N 25_R 1.437 1.00
61_L 282_L 1.427 1.00
64_A 282_L 1.421 1.00
136_L 139_G 1.415 1.00
134_L 231_T 1.413 1.00
248_L 252_S 1.392 0.99
234_V 280_L 1.381 0.99
254_I 257_S 1.375 0.99
14_F 25_R 1.363 0.99
122_A 125_L 1.36 0.99
105_I 108_I 1.358 0.99
232_L 260_H 1.353 0.99
135_V 232_L 1.352 0.99
277_F 281_V 1.352 0.99
26_I 79_S 1.334 0.99
225_A 253_G 1.334 0.99
37_T 105_I 1.329 0.99
42_H 73_C 1.322 0.99
29_N 48_A 1.321 0.99
101_D 127_W 1.32 0.99
276_A 279_Q 1.307 0.99
113_N 270_Q 1.29 0.99
88_R 91_L 1.285 0.99
58_I 70_L 1.268 0.99
72_D 77_G 1.264 0.99
45_G 114_S 1.263 0.99
93_A 119_S 1.254 0.99
71_L 99_V 1.248 0.99
123_F 130_R 1.241 0.98
66_Y 286_A 1.233 0.98
265_C 272_E 1.23 0.98
265_C 269_A 1.226 0.98
235_W 247_G 1.22 0.98
27_H 72_D 1.211 0.98
237_R 264_D 1.211 0.98
39_V 96_L 1.19 0.98
111_L 281_V 1.182 0.98
39_V 108_I 1.177 0.98
61_L 64_A 1.173 0.98
125_L 223_R 1.172 0.98
99_V 103_L 1.168 0.97
135_V 285_L 1.168 0.97
121_V 136_L 1.163 0.97
244_M 248_L 1.156 0.97
61_L 275_D 1.153 0.97
18_E 21_G 1.143 0.97
111_L 135_V 1.143 0.97
18_E 98_S 1.13 0.97
27_H 48_A 1.125 0.97
251_L 259_L 1.112 0.96
111_L 137_M 1.107 0.96
26_I 95_I 1.107 0.96
24_L 74_P 1.105 0.96
110_L 123_F 1.105 0.96
38_V 111_L 1.103 0.96
32_G 67_R 1.097 0.96
35_D 109_H 1.095 0.96
48_A 70_L 1.094 0.96
48_A 78_K 1.093 0.96
185_T 188_L 1.087 0.96
266_G 272_E 1.085 0.96
248_L 259_L 1.085 0.96
69_I 103_L 1.076 0.95
66_Y 285_L 1.068 0.95
234_V 262_F 1.067 0.95
275_D 279_Q 1.064 0.95
262_F 273_H 1.063 0.95
262_F 276_A 1.053 0.95
108_I 131_V 1.047 0.94
46_P 50_G 1.047 0.94
133_K 284_F 1.045 0.94
260_H 276_A 1.042 0.94
258_E 280_L 1.035 0.94
43_G 114_S 1.03 0.94
39_V 110_L 1.028 0.94
232_L 258_E 1.01 0.93
235_W 244_M 1.007 0.93
133_K 230_Q 1.006 0.93
204_E 208_K 1.005 0.93
97_K 126_K 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2pujA10.98261000.105Contact Map0.856
1u2eA40.99311000.118Contact Map0.855
1ehyA40.94791000.153Contact Map0.81
1iupA10.9341000.154Contact Map0.828
2wueA20.98611000.162Contact Map0.843
3oosA10.92711000.18Contact Map0.749
4lxhA10.94791000.186Contact Map0.822
1c4xA10.95141000.193Contact Map0.807
2xuaA20.89931000.2Contact Map0.85
3om8A20.90621000.206Contact Map0.784
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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