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OPENSEQ.org

YBFF - Esterase YbfF
UniProt: P75736 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11776
Length: 254 (249)
Sequences: 23103
Seq/Len: 92.78

YBFF
Paralog alert: 0.80 [within 20: 0.26] - ratio of genomes with paralogs
Cluster includes: BIOH DLHH MENH MHPC PLDB RUTD YBFF YCJY YFHR YGHX YJFP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
84_T 108_K 4.234 1.00
7_A 44_N 3.758 1.00
51_R 70_D 3.727 1.00
35_L 245_L 3.087 1.00
204_G 230_A 2.958 1.00
240_K 243_A 2.813 1.00
199_L 251_Y 2.735 1.00
72_V 98_L 2.638 1.00
82_K 107_D 2.609 1.00
227_H 247_A 2.592 1.00
84_T 107_D 2.463 1.00
112_I 244_V 2.437 1.00
76_D 105_R 2.246 1.00
42_D 249_R 2.21 1.00
229_I 247_A 2.14 1.00
72_V 102_A 2.102 1.00
204_G 228_V 2.083 1.00
218_L 224_A 2.065 1.00
75_L 83_A 2.063 1.00
113_D 206_S 2.039 1.00
98_L 102_A 1.988 1.00
92_G 114_I 1.951 1.00
69_Q 101_L 1.926 1.00
85_F 95_V 1.91 1.00
232_A 240_K 1.86 1.00
99_T 109_L 1.842 1.00
72_V 76_D 1.802 1.00
72_V 105_R 1.8 1.00
198_A 221_F 1.797 1.00
110_V 248_I 1.771 1.00
97_A 101_L 1.765 1.00
211_E 228_V 1.753 1.00
5_I 74_T 1.745 1.00
84_T 110_V 1.735 1.00
95_V 109_L 1.731 1.00
38_D 245_L 1.7 1.00
84_T 252_L 1.696 1.00
2_K 57_P 1.686 1.00
18_P 44_N 1.681 1.00
22_V 50_M 1.68 1.00
18_P 46_I 1.672 1.00
48_V 71_L 1.647 1.00
216_D 220_Q 1.64 1.00
6_R 29_L 1.617 1.00
26_F 89_S 1.585 1.00
4_N 55_L 1.555 1.00
247_A 250_R 1.554 1.00
22_V 71_L 1.554 1.00
36_A 47_Q 1.531 1.00
246_R 250_R 1.526 1.00
71_L 98_L 1.523 1.00
21_L 86_I 1.521 1.00
22_V 95_V 1.507 1.00
46_I 74_T 1.506 1.00
229_I 232_A 1.49 1.00
29_L 55_L 1.486 1.00
65_P 101_L 1.464 1.00
190_K 193_A 1.463 1.00
50_M 94_A 1.45 1.00
102_A 105_R 1.444 1.00
243_A 247_A 1.401 0.99
7_A 46_I 1.397 0.99
111_A 114_I 1.397 0.99
68_A 97_A 1.395 0.99
27_G 31_N 1.381 0.99
38_D 249_R 1.366 0.99
23_H 53_H 1.363 0.99
4_N 29_L 1.361 0.99
98_L 106_I 1.356 0.99
21_L 45_I 1.348 0.99
3_L 56_S 1.341 0.99
199_L 227_H 1.337 0.99
29_L 49_D 1.331 0.99
43_H 84_T 1.325 0.99
110_V 199_L 1.319 0.99
244_V 248_I 1.31 0.99
215_D 219_A 1.307 0.99
17_S 84_T 1.3 0.99
109_L 198_A 1.296 0.99
97_A 100_A 1.294 0.99
80_I 83_A 1.29 0.99
63_N 66_A 1.288 0.99
221_F 224_A 1.285 0.99
20_V 75_L 1.281 0.99
202_P 214_R 1.276 0.99
76_D 102_A 1.268 0.99
18_P 80_I 1.26 0.99
75_L 80_I 1.252 0.99
232_A 239_E 1.244 0.98
201_I 247_A 1.227 0.98
88_H 237_H 1.22 0.98
8_Q 47_Q 1.22 0.98
23_H 50_M 1.218 0.98
48_V 74_T 1.208 0.98
192_P 220_Q 1.193 0.98
98_L 105_R 1.192 0.98
74_T 78_Q 1.192 0.98
232_A 236_V 1.191 0.98
38_D 41_N 1.187 0.98
243_A 246_R 1.187 0.98
96_M 111_A 1.182 0.98
68_A 94_A 1.179 0.98
86_I 112_I 1.168 0.97
9_T 16_N 1.162 0.97
17_S 107_D 1.162 0.97
86_I 248_I 1.155 0.97
211_E 215_D 1.15 0.97
29_L 47_Q 1.143 0.97
20_V 71_L 1.141 0.97
49_D 54_G 1.135 0.97
38_D 242_D 1.133 0.97
204_G 231_G 1.124 0.97
43_H 253_N 1.115 0.96
19_I 86_I 1.109 0.96
215_D 226_A 1.107 0.96
20_V 83_A 1.084 0.96
233_G 239_E 1.075 0.95
201_I 229_I 1.073 0.95
83_A 106_I 1.059 0.95
225_R 247_A 1.054 0.95
242_D 246_R 1.05 0.94
218_L 226_A 1.049 0.94
72_V 101_L 1.049 0.94
19_I 43_H 1.04 0.94
26_F 53_H 1.039 0.94
215_D 228_V 1.036 0.94
100_A 190_K 1.035 0.94
24_G 89_S 1.026 0.94
216_D 219_A 1.023 0.93
202_P 211_E 1.019 0.93
110_V 252_L 1.008 0.93
86_I 110_V 1.007 0.93
202_P 228_V 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3bf7A211000.017Contact Map0.77
1ehyA40.97241000.082Contact Map0.797
3oosA10.96851000.087Contact Map0.711
3om8A20.95281000.094Contact Map0.782
2pujA10.96061000.108Contact Map0.828
2xuaA20.96461000.11Contact Map0.85
1iupA10.94881000.113Contact Map0.816
1q0rA10.97641000.118Contact Map0.799
2xmzA10.94881000.119Contact Map0.728
1womA20.96851000.125Contact Map0.753

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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