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YCJY - Uncharacterized protein YcjY
UniProt: P76049 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13922
Length: 306 (295)
Sequences: 19235
Seq/Len: 65.20

YCJY
Paralog alert: 0.86 [within 20: 0.26] - ratio of genomes with paralogs
Cluster includes: BIOH DLHH MENH MHPC PLDB RUTD YBFF YCJY YFHR YGHX YJFP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
112_G 135_A 4.668 1.00
71_S 92_D 4.593 1.00
251_S 277_E 3.532 1.00
274_H 297_V 2.939 1.00
54_Y 295_I 2.896 1.00
61_K 299_A 2.857 1.00
246_Q 301_F 2.803 1.00
22_I 64_V 2.757 1.00
276_V 297_V 2.64 1.00
98_D 132_R 2.618 1.00
272_R 304_E 2.551 1.00
240_Y 243_Q 2.53 1.00
127_A 136_I 2.503 1.00
263_Y 271_K 2.499 1.00
94_S 126_A 2.455 1.00
110_R 134_K 2.406 1.00
97_I 111_I 2.394 1.00
139_V 294_A 2.303 1.00
113_A 123_T 2.266 1.00
112_G 302_F 2.229 1.00
17_S 77_G 2.201 1.00
112_G 134_K 2.181 1.00
251_S 275_I 2.141 1.00
123_T 136_I 2.14 1.00
94_S 130_D 2.091 1.00
91_E 129_Q 2.087 1.00
256_K 275_I 2.061 1.00
137_G 298_L 2.036 1.00
120_A 141_A 1.944 1.00
126_A 130_D 1.91 1.00
94_S 98_D 1.907 1.00
236_M 239_V 1.888 1.00
40_S 93_I 1.868 1.00
296_S 300_P 1.85 1.00
112_G 137_G 1.847 1.00
272_R 297_V 1.834 1.00
138_T 141_A 1.805 1.00
245_T 266_A 1.781 1.00
287_G 293_E 1.775 1.00
36_A 64_V 1.757 1.00
68_Y 93_I 1.719 1.00
21_V 47_K 1.716 1.00
40_S 70_A 1.689 1.00
55_A 67_A 1.686 1.00
66_I 96_V 1.684 1.00
125_N 129_Q 1.675 1.00
137_G 302_F 1.673 1.00
297_V 300_P 1.665 1.00
12_N 17_S 1.664 1.00
293_E 297_V 1.661 1.00
57_K 295_I 1.616 1.00
63_F 303_E 1.614 1.00
279_A 287_G 1.607 1.00
260_D 264_D 1.592 1.00
41_H 73_Q 1.582 1.00
261_D 265_R 1.579 1.00
276_V 279_A 1.578 1.00
93_I 126_A 1.561 1.00
36_A 66_I 1.549 1.00
136_I 245_T 1.539 1.00
39_L 114_M 1.531 1.00
22_I 66_I 1.517 1.00
40_S 123_T 1.493 1.00
7_S 17_S 1.489 1.00
260_D 275_I 1.483 1.00
57_K 60_E 1.475 1.00
94_S 132_R 1.467 1.00
137_G 246_Q 1.46 1.00
20_A 96_V 1.453 1.00
47_K 75_E 1.443 1.00
47_K 67_A 1.439 1.00
294_A 298_L 1.427 1.00
69_D 74_G 1.424 1.00
246_Q 274_H 1.423 1.00
249_A 256_K 1.415 1.00
70_A 122_Y 1.406 0.99
251_S 278_G 1.403 0.99
238_E 265_R 1.389 0.99
61_K 303_E 1.386 0.99
57_K 299_A 1.386 0.99
256_K 260_D 1.38 0.99
260_D 273_Y 1.346 0.99
41_H 70_A 1.34 0.99
249_A 259_S 1.337 0.99
87_Y 129_Q 1.337 0.99
90_T 125_N 1.331 0.99
39_L 65_T 1.327 0.99
25_P 64_V 1.322 0.99
98_D 130_D 1.321 0.99
126_A 133_I 1.319 0.99
108_N 111_I 1.316 0.99
59_A 65_T 1.314 0.99
100_L 108_N 1.306 0.99
124_A 138_T 1.304 0.99
97_I 108_N 1.302 0.99
47_K 69_D 1.301 0.99
19_S 75_E 1.292 0.99
44_G 117_C 1.289 0.99
252_Q 278_G 1.279 0.99
292_A 296_S 1.279 0.99
248_V 276_V 1.273 0.99
63_F 302_F 1.268 0.99
37_I 114_M 1.261 0.99
42_P 117_C 1.259 0.99
18_L 76_S 1.255 0.99
94_S 129_Q 1.25 0.99
35_Q 112_G 1.245 0.98
63_F 112_G 1.245 0.98
274_H 293_E 1.238 0.98
8_F 96_V 1.237 0.98
248_V 294_A 1.236 0.98
37_I 63_F 1.22 0.98
125_N 128_I 1.22 0.98
114_M 139_V 1.211 0.98
259_S 273_Y 1.209 0.98
96_V 100_L 1.203 0.98
101_T 108_N 1.194 0.98
293_E 296_S 1.188 0.98
114_M 298_L 1.184 0.98
4_N 103_L 1.18 0.98
34_Y 64_V 1.178 0.98
38_V 97_I 1.176 0.98
68_Y 96_V 1.175 0.98
90_T 122_Y 1.169 0.97
128_I 236_M 1.162 0.97
276_V 293_E 1.159 0.97
135_A 301_F 1.147 0.97
45_G 49_Q 1.144 0.97
114_M 137_G 1.141 0.97
113_A 126_A 1.137 0.97
23_Y 67_A 1.137 0.97
263_Y 273_Y 1.136 0.97
24_F 27_K 1.125 0.97
266_A 271_K 1.116 0.96
35_Q 63_F 1.114 0.96
85_N 88_I 1.101 0.96
111_I 133_I 1.1 0.96
261_D 264_D 1.093 0.96
4_N 24_F 1.085 0.96
95_A 98_D 1.082 0.96
125_N 236_M 1.08 0.95
97_I 126_A 1.079 0.95
35_Q 134_K 1.071 0.95
37_I 65_T 1.07 0.95
37_I 58_L 1.067 0.95
66_I 100_L 1.064 0.95
247_I 259_S 1.057 0.95
117_C 281_H 1.055 0.95
62_G 299_A 1.05 0.94
57_K 292_A 1.043 0.94
38_V 113_A 1.039 0.94
251_S 256_K 1.039 0.94
248_V 297_V 1.034 0.94
38_V 111_I 1.033 0.94
19_S 47_K 1.025 0.93
16_I 71_S 1.023 0.93
40_S 68_Y 1.008 0.93
299_A 303_E 1.007 0.93
44_G 73_Q 1.004 0.93
113_A 133_I 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3om8A20.84311000.205Contact Map0.762
2xuaA20.83991000.222Contact Map0.862
1mtzA10.91181000.226Contact Map0.786
1ehyA40.87251000.23Contact Map0.788
3fobA30.87581000.23Contact Map0.839
2pujA10.86271000.23Contact Map0.834
2xmzA10.84971000.235Contact Map0.758
3oosA10.86271000.236Contact Map0.728
1zoiA30.86271000.237Contact Map0.814
3v48A20.83331000.237Contact Map0.764

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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