| UniProt: | P56262 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG14321 | ||
| Length: | 271 (240) | ||
| Sequences: | 13020 | ||
| Seq/Len: | 54.25 |
| DLHH
Paralog alert: 0.79 [within 20: 0.24] - ratio of genomes with paralogs Cluster includes: BIOH DLHH MENH MHPC PLDB RUTD YBFF YCJY YFHR YGHX YJFP |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 142_M | 165_A | 3.359 | 1.00 | |
| 92_Y | 123_D | 3.323 | 1.00 | |
| 34_S | 41_N | 2.9 | 1.00 | |
| 157_A | 166_A | 2.813 | 1.00 | |
| 82_E | 259_L | 2.806 | 1.00 | |
| 202_G | 232_P | 2.7 | 1.00 | |
| 62_V | 124_L | 2.459 | 1.00 | |
| 229_I | 257_R | 2.453 | 1.00 | |
| 153_T | 166_A | 2.437 | 1.00 | |
| 227_E | 257_R | 2.35 | 1.00 | |
| 142_M | 262_F | 2.302 | 1.00 | |
| 231_Y | 257_R | 2.292 | 1.00 | |
| 130_W | 134_N | 2.218 | 1.00 | |
| 142_M | 266_G | 2.188 | 1.00 | |
| 36_P | 41_N | 2.114 | 1.00 | |
| 49_P | 85_L | 2.07 | 1.00 | |
| 216_R | 226_A | 2.07 | 1.00 | |
| 213_E | 230_V | 2.067 | 1.00 | |
| 168_A | 171_G | 2.028 | 1.00 | |
| 167_V | 262_F | 2.001 | 1.00 | |
| 84_Y | 263_K | 1.967 | 1.00 | |
| 167_V | 258_M | 1.954 | 1.00 | |
| 137_D | 140_R | 1.953 | 1.00 | |
| 165_A | 265_Y | 1.899 | 1.00 | |
| 227_E | 264_Q | 1.872 | 1.00 | |
| 44_A | 87_I | 1.855 | 1.00 | |
| 202_G | 230_V | 1.838 | 1.00 | |
| 58_V | 85_L | 1.826 | 1.00 | |
| 143_I | 153_T | 1.809 | 1.00 | |
| 46_H | 85_L | 1.804 | 1.00 | |
| 33_T | 44_A | 1.796 | 1.00 | |
| 38_Q | 126_H | 1.793 | 1.00 | |
| 231_Y | 253_D | 1.772 | 1.00 | |
| 253_D | 257_R | 1.77 | 1.00 | |
| 58_V | 136_G | 1.744 | 1.00 | |
| 82_E | 263_K | 1.723 | 1.00 | |
| 209_Q | 230_V | 1.719 | 1.00 | |
| 35_I | 127_V | 1.716 | 1.00 | |
| 216_R | 228_I | 1.707 | 1.00 | |
| 58_V | 131_A | 1.698 | 1.00 | |
| 46_H | 87_I | 1.692 | 1.00 | |
| 217_Q | 221_A | 1.66 | 1.00 | |
| 197_L | 261_W | 1.651 | 1.00 | |
| 31_G | 48_R | 1.644 | 1.00 | |
| 56_L | 85_L | 1.632 | 1.00 | |
| 256_Q | 260_E | 1.621 | 1.00 | |
| 213_E | 217_Q | 1.607 | 1.00 | |
| 225_K | 265_Y | 1.51 | 1.00 | |
| 87_I | 127_V | 1.508 | 1.00 | |
| 129_S | 133_R | 1.507 | 1.00 | |
| 48_R | 85_L | 1.499 | 1.00 | |
| 32_F | 43_P | 1.483 | 1.00 | |
| 203_Q | 233_D | 1.475 | 1.00 | |
| 125_D | 129_S | 1.47 | 1.00 | |
| 154_W | 168_A | 1.462 | 1.00 | |
| 165_A | 261_W | 1.461 | 1.00 | |
| 128_A | 163_L | 1.443 | 1.00 | |
| 130_W | 133_R | 1.443 | 1.00 | |
| 47_A | 88_A | 1.419 | 1.00 | |
| 188_I | 191_D | 1.415 | 1.00 | |
| 64_E | 147_C | 1.408 | 1.00 | |
| 59_V | 144_T | 1.375 | 0.99 | |
| 89_P | 127_V | 1.34 | 0.99 | |
| 140_R | 164_K | 1.339 | 0.99 | |
| 202_G | 233_D | 1.328 | 0.99 | |
| 73_R | 77_R | 1.324 | 0.99 | |
| 261_W | 265_Y | 1.32 | 0.99 | |
| 78_R | 82_E | 1.318 | 0.99 | |
| 59_V | 84_Y | 1.316 | 0.99 | |
| 87_I | 131_A | 1.313 | 0.99 | |
| 125_D | 156_Y | 1.306 | 0.99 | |
| 199_L | 231_Y | 1.306 | 0.99 | |
| 209_Q | 213_E | 1.303 | 0.99 | |
| 38_Q | 122_A | 1.288 | 0.99 | |
| 257_R | 260_E | 1.288 | 0.99 | |
| 76_C | 88_A | 1.286 | 0.99 | |
| 125_D | 160_N | 1.283 | 0.99 | |
| 199_L | 254_G | 1.272 | 0.99 | |
| 200_Y | 212_V | 1.27 | 0.99 | |
| 231_Y | 234_A | 1.267 | 0.99 | |
| 77_R | 81_L | 1.26 | 0.99 | |
| 166_A | 196_I | 1.235 | 0.98 | |
| 216_R | 220_R | 1.234 | 0.98 | |
| 35_I | 44_A | 1.232 | 0.98 | |
| 169_W | 258_M | 1.227 | 0.98 | |
| 126_H | 129_S | 1.223 | 0.98 | |
| 168_A | 198_G | 1.218 | 0.98 | |
| 167_V | 197_L | 1.217 | 0.98 | |
| 146_F | 170_Y | 1.216 | 0.98 | |
| 128_A | 141_L | 1.205 | 0.98 | |
| 219_L | 224_A | 1.202 | 0.98 | |
| 31_G | 134_N | 1.201 | 0.98 | |
| 259_L | 263_K | 1.198 | 0.98 | |
| 41_N | 98_P | 1.198 | 0.98 | |
| 143_I | 156_Y | 1.191 | 0.98 | |
| 198_G | 212_V | 1.174 | 0.98 | |
| 59_V | 79_L | 1.169 | 0.97 | |
| 58_V | 87_I | 1.167 | 0.97 | |
| 260_E | 264_Q | 1.151 | 0.97 | |
| 200_Y | 209_Q | 1.147 | 0.97 | |
| 44_A | 127_V | 1.142 | 0.97 | |
| 61_V | 144_T | 1.141 | 0.97 | |
| 34_S | 43_P | 1.135 | 0.97 | |
| 45_Y | 69_H | 1.13 | 0.97 | |
| 125_D | 159_H | 1.129 | 0.97 | |
| 85_L | 136_G | 1.121 | 0.97 | |
| 49_P | 56_L | 1.118 | 0.96 | |
| 214_T | 218_A | 1.116 | 0.96 | |
| 61_V | 76_C | 1.109 | 0.96 | |
| 78_R | 81_L | 1.106 | 0.96 | |
| 124_L | 156_Y | 1.102 | 0.96 | |
| 199_L | 229_I | 1.101 | 0.96 | |
| 166_A | 194_A | 1.1 | 0.96 | |
| 165_A | 262_F | 1.098 | 0.96 | |
| 144_T | 167_V | 1.082 | 0.96 | |
| 213_E | 228_I | 1.081 | 0.95 | |
| 196_I | 219_L | 1.076 | 0.95 | |
| 248_A | 252_E | 1.065 | 0.95 | |
| 78_R | 259_L | 1.058 | 0.95 | |
| 129_S | 162_Q | 1.05 | 0.94 | |
| 220_R | 226_A | 1.046 | 0.94 | |
| 59_V | 262_F | 1.044 | 0.94 | |
| 52_S | 56_L | 1.039 | 0.94 | |
| 198_G | 216_R | 1.035 | 0.94 | |
| 234_A | 250_S | 1.031 | 0.94 | |
| 252_E | 256_Q | 1.028 | 0.94 | |
| 47_A | 80_A | 1.026 | 0.94 | |
| 57_P | 137_D | 1.021 | 0.93 | |
| 59_V | 86_A | 1.016 | 0.93 | |
| 229_I | 253_D | 1.014 | 0.93 | |
| 122_A | 159_H | 1.01 | 0.93 | |
| 154_W | 215_M | 1.005 | 0.93 | |
| 210_E | 213_E | 1.003 | 0.93 | |
| 253_D | 256_Q | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3f67A | 1 | 0.8893 | 100 | 0.372 | Contact Map | 0.709 |
| 1xfdA | 4 | 0.9336 | 100 | 0.393 | Contact Map | 0.728 |
| 2ecfA | 1 | 0.9336 | 100 | 0.394 | Contact Map | 0.732 |
| 2z3zA | 1 | 0.9262 | 100 | 0.4 | Contact Map | 0.775 |
| 4hvtA | 1 | 0.9483 | 100 | 0.408 | Contact Map | 0.72 |
| 1zi8A | 1 | 0.845 | 100 | 0.409 | Contact Map | 0.607 |
| 3o4hA | 4 | 0.9188 | 100 | 0.41 | Contact Map | 0.809 |
| 4a5sA | 2 | 0.941 | 100 | 0.412 | Contact Map | 0.774 |
| 1z68A | 2 | 0.9299 | 100 | 0.416 | Contact Map | 0.809 |
| 2hdwA | 2 | 0.9004 | 100 | 0.418 | Contact Map | 0.781 |
Sequence Conservation (Image Generated using WebLogo v3)