OPENSEQ.org - YFCP - ECOLI GREMLIN

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YFCP - Uncharacterized fimbrial-like protein YfcP

UniProt:	P76499	Sequence MNKSMIQSGGYVLLAGLILAMSSTLFAADNNLHFSGNLLSKSCALVVDGQYLAEVRFPTVSRQDLNVAGQSARVPVVFKLKDCKGPAGYNVKVTLTGVEDSEQPGFLALDTSSTAQGVGIGMEKTDGMQVAINNTNGATFALTNGNNDINFRAWLQAKSGRDVTIGEFTASLTATFEYI	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG14119
Length:	179 (155)
Sequences:	1492
Seq/Len:	9.63

YFCP
Paralog alert: 0.95 [within 20: 0.79] - ratio of genomes with paralogs
Cluster includes: ELFA FIMA1 FIMF FIMG FIMI SFMA SFMF YADN YBGD YCBU YCBV YDER YDES YFCP YFCV YGIL YRAH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
120_I	153_A	3.463	1.00
91_V	176_F	3.035	1.00
116_Q	164_T	3.033	1.00
121_G	154_W	2.943	1.00
121_G	156_Q	2.759	1.00
123_E	154_W	2.591	1.00
106_F	119_G	2.494	1.00
77_V	148_D	2.462	1.00
155_L	168_F	2.446	1.00
46_V	81_K	2.406	1.00
109_L	168_F	2.282	1.00
46_V	49_G	2.197	1.00
44_A	82_D	2.192	1.00
117_G	163_V	2.181	1.00
46_V	79_K	2.172	1.00
107_L	172_L	2.149	1.00
120_I	170_A	2.082	1.00
107_L	132_I	1.969	1.00
124_K	128_M	1.939	1.00
121_G	129_Q	1.774	1.00
99_E	105_G	1.612	1.00
49_G	53_A	1.611	1.00
57_F	168_F	1.6	1.00
77_V	150_N	1.563	1.00
93_V	149_I	1.54	1.00
65_L	157_A	1.507	1.00
117_G	161_R	1.491	1.00
75_P	152_R	1.49	1.00
40_S	62_R	1.489	1.00
97_G	107_L	1.462	1.00
60_V	71_S	1.42	0.99
142_L	147_N	1.389	0.99
44_A	81_K	1.387	0.99
106_F	156_Q	1.371	0.99
49_G	79_K	1.37	0.99
79_K	148_D	1.365	0.99
107_L	170_A	1.361	0.99
58_P	72_A	1.316	0.99
70_Q	154_W	1.305	0.99
57_F	120_I	1.282	0.99
65_L	158_K	1.25	0.98
58_P	168_F	1.245	0.98
64_D	71_S	1.223	0.98
127_G	152_R	1.222	0.98
90_N	141_A	1.218	0.98
51_Y	54_E	1.21	0.98
65_L	163_V	1.205	0.98
38_L	60_V	1.198	0.98
37_N	59_T	1.189	0.98
65_L	118_V	1.183	0.98
118_V	155_L	1.182	0.97
157_A	163_V	1.177	0.97
53_A	174_A	1.171	0.97
76_V	122_M	1.167	0.97
57_F	155_L	1.134	0.97
115_A	118_V	1.129	0.96
53_A	78_F	1.129	0.96
100_D	119_G	1.112	0.96
42_S	147_N	1.111	0.96
33_H	171_S	1.11	0.96
107_L	120_I	1.082	0.95
60_V	168_F	1.072	0.95
30_N	174_A	1.071	0.95
94_T	177_E	1.066	0.95
92_K	177_E	1.059	0.94
50_Q	53_A	1.043	0.94
96_T	133_N	1.04	0.94
73_R	154_W	1.035	0.93
106_F	121_G	1.022	0.93
60_V	155_L	1.009	0.92
57_F	74_V	1.007	0.92
114_T	167_E	1.005	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
2jmrA	1	0.8324	100	0.286	Contact Map	0.655
2xg5B	1	0.9162	100	0.294	Contact Map	0.732
2jtyA	1	0.8547	100	0.302	Contact Map	0.732
2uy6B	2	0.8547	100	0.303	Contact Map	0.867
1pdkB	1	0.8268	100	0.33	Contact Map	0.69
4dwhB	2	0.7654	99.9	0.385	Contact Map	0.785
3bwuF	1	0.7598	99.9	0.387	Contact Map	0.806
2w07B	1	0.7821	99.9	0.397	Contact Map	0.702
3bfqG	1	0.7207	99.9	0.422	Contact Map	0.725
3jwnH	2	0.8939	99.9	0.463	Contact Map	0.721

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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