OPENSEQ.org - FIMI - ECOLI GREMLIN

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FIMI - Fimbrin-like protein FimI

UniProt:	P39264	Sequence MKRKRLFLLASLLPMFALAGNKWNTTLPGGNMQFQGVIIAETCRIEAGDKQMTVNMGQISSNRFHAVGEDSAPVPFVIHLRECSTVVSERVGVAFHGVADGKNPDVLSVGEGPGIATNIGVALFDDEGNLVPINRPPANWKRLYSGSTSLHFIAKYRATGRRVTGGIANAQAWFSLTYQ	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG11974
Length:	179 (161)
Sequences:	1513
Seq/Len:	9.40

FIMI
Paralog alert: 0.95 [within 20: 0.80] - ratio of genomes with paralogs
Cluster includes: ELFA FIMA1 FIMF FIMG FIMI SFMA SFMF YADN YBGD YCBU YCBV YDER YDES YFCP YFCV YGIL YRAH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
121_V	154_A	3.21	1.00
91_V	176_L	3.034	1.00
117_T	164_T	2.868	1.00
66_A	69_E	2.856	1.00
122_A	155_K	2.769	1.00
122_A	157_R	2.724	1.00
106_V	120_G	2.534	1.00
77_V	149_S	2.466	1.00
124_F	155_K	2.422	1.00
118_N	163_V	2.32	1.00
46_E	81_R	2.295	1.00
109_V	168_A	2.264	1.00
156_Y	168_A	2.256	1.00
46_E	49_D	2.172	1.00
44_R	82_E	2.16	1.00
46_E	79_H	2.151	1.00
107_L	133_I	2.14	1.00
107_L	172_A	2.138	1.00
121_V	170_A	2.128	1.00
125_D	129_N	2.096	1.00
65_H	69_E	1.965	1.00
122_A	130_L	1.728	1.00
77_V	151_H	1.656	1.00
40_A	61_S	1.579	1.00
56_M	168_A	1.503	1.00
99_A	105_D	1.475	1.00
75_P	153_I	1.43	0.99
59_I	71_S	1.421	0.99
49_D	79_H	1.393	0.99
64_F	158_A	1.384	0.99
79_H	149_S	1.375	0.99
93_V	150_L	1.375	0.99
119_I	156_Y	1.366	0.99
106_V	157_R	1.364	0.99
143_L	148_T	1.336	0.99
100_D	159_T	1.319	0.99
57_G	168_A	1.303	0.99
56_M	121_V	1.302	0.99
116_A	119_I	1.3	0.99
49_D	52_M	1.292	0.99
64_F	159_T	1.284	0.99
19_A	23_W	1.261	0.98
97_G	107_L	1.25	0.98
107_L	121_V	1.244	0.98
44_R	81_R	1.236	0.98
26_T	29_G	1.224	0.98
70_D	122_A	1.193	0.98
57_G	72_A	1.184	0.97
73_P	155_K	1.183	0.97
128_G	153_I	1.178	0.97
37_V	58_Q	1.178	0.97
20_G	23_W	1.174	0.97
107_L	170_A	1.172	0.97
52_M	78_I	1.172	0.97
56_M	156_Y	1.148	0.97
38_I	59_I	1.136	0.96
30_G	174_F	1.12	0.96
52_M	174_F	1.119	0.96
64_F	163_V	1.118	0.96
96_H	134_N	1.111	0.96
64_F	119_I	1.1	0.96
94_A	177_T	1.077	0.95
76_F	123_L	1.075	0.95
158_A	163_V	1.062	0.94
33_Q	171_Q	1.054	0.94
70_D	155_K	1.047	0.94
98_V	108_S	1.045	0.94
66_A	158_A	1.043	0.94
115_I	167_I	1.039	0.93
67_V	118_N	1.03	0.93
123_L	133_I	1.029	0.93
21_N	24_N	1.024	0.93
70_D	124_F	1.023	0.93
101_G	120_G	1.016	0.92
42_T	148_T	1.014	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
2jmrA	1	0.8492	100	0.283	Contact Map	0.638
2jtyA	1	0.8715	100	0.295	Contact Map	0.716
2xg5B	1	0.9274	100	0.308	Contact Map	0.699
2uy6B	2	0.8436	100	0.31	Contact Map	0.822
1pdkB	1	0.8268	100	0.324	Contact Map	0.663
3bwuF	1	0.7765	99.9	0.373	Contact Map	0.782
4dwhB	2	0.7821	99.9	0.375	Contact Map	0.746
2w07B	1	0.7821	99.9	0.402	Contact Map	0.697
3bfqG	1	0.7263	99.9	0.413	Contact Map	0.688
3jwnH	2	0.8994	99.9	0.443	Contact Map	0.726

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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