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OPENSEQ.org
ELFA - Fimbrial subunit ElfA
UniProt: P75855 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13709
Length: 179 (176)
Sequences: 1504
Seq/Len: 8.55
ELFA
Paralog alert: 0.95 [within 20: 0.78] - ratio of genomes with paralogs
Cluster includes: ELFA FIMA1 FIMF FIMG FIMI SFMA SFMF YADN YBGD YCBU YCBV YDER YDES YFCP YFCV YGIL YRAH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
122_L 155_V 3.329 1.00
118_T 164_T 2.826 1.00
92_A 176_I 2.821 1.00
123_Q 156_D 2.709 1.00
66_T 69_Q 2.537 1.00
123_Q 158_I 2.513 1.00
125_Y 156_D 2.403 1.00
78_P 150_T 2.353 1.00
157_Y 168_V 2.335 1.00
46_V 82_K 2.21 1.00
46_V 80_E 2.07 1.00
107_A 121_A 2.063 1.00
44_T 83_D 2.005 1.00
110_N 168_V 1.916 1.00
122_L 170_A 1.884 1.00
108_F 172_T 1.85 1.00
108_F 135_P 1.813 1.00
59_V 71_S 1.689 1.00
46_V 49_T 1.684 1.00
65_Q 69_Q 1.675 1.00
126_M 130_T 1.654 1.00
123_Q 132_A 1.648 1.00
56_L 168_V 1.597 1.00
64_L 159_A 1.491 1.00
119_N 161_G 1.474 1.00
78_P 152_T 1.459 0.99
76_D 154_K 1.456 0.99
94_F 151_L 1.446 0.99
40_A 61_A 1.434 0.99
49_T 80_E 1.385 0.99
80_E 150_T 1.384 0.99
56_L 122_L 1.334 0.99
98_G 108_F 1.316 0.99
57_P 168_V 1.311 0.99
52_S 79_I 1.303 0.99
49_T 52_S 1.301 0.99
44_T 82_K 1.291 0.98
56_L 157_Y 1.284 0.98
100_A 106_T 1.284 0.98
16_T 20_M 1.276 0.98
8_A 12_V 1.276 0.98
13_V 18_S 1.258 0.98
8_A 11_T 1.255 0.98
144_L 149_Q 1.25 0.98
134_T 137_T 1.249 0.98
116_A 167_N 1.248 0.98
15_A 19_V 1.245 0.98
52_S 174_F 1.24 0.98
57_P 72_G 1.229 0.98
2_K 5_V 1.213 0.97
101_D 160_T 1.209 0.97
108_F 170_A 1.202 0.97
107_A 158_I 1.188 0.97
120_V 157_Y 1.181 0.97
3_K 6_L 1.18 0.97
117_A 120_V 1.176 0.97
38_V 59_V 1.159 0.96
6_L 14_C 1.13 0.96
76_D 152_T 1.129 0.96
129_G 154_K 1.126 0.95
5_V 8_A 1.124 0.95
37_K 58_D 1.121 0.95
108_F 122_L 1.12 0.95
64_L 120_V 1.107 0.95
64_L 67_N 1.101 0.95
5_V 12_V 1.096 0.94
9_F 12_V 1.092 0.94
16_T 21_A 1.09 0.94
14_C 20_M 1.088 0.94
119_N 163_A 1.072 0.94
7_T 10_I 1.066 0.93
3_K 8_A 1.05 0.93
95_T 177_N 1.05 0.93
3_K 9_F 1.049 0.93
101_D 121_A 1.042 0.92
59_V 168_V 1.04 0.92
14_C 21_A 1.037 0.92
2_K 12_V 1.037 0.92
70_V 158_I 1.031 0.92
42_A 149_Q 1.029 0.92
17_S 20_M 1.029 0.92
99_T 109_A 1.022 0.91
124_M 135_P 1.019 0.91
38_V 155_V 1.016 0.91
107_A 123_Q 1.014 0.91
64_L 160_T 1.011 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2jmrA10.8381000.234Contact Map0.682
2jtyA10.86591000.244Contact Map0.711
2xg5B10.92181000.255Contact Map0.679
2uy6B20.8381000.271Contact Map0.832
1pdkB10.81561000.278Contact Map0.65
4dwhB20.776599.90.329Contact Map0.75
3bwuF10.765499.90.336Contact Map0.775
2w07B10.770999.90.366Contact Map0.693
3bfqG10.720799.90.382Contact Map0.693
3jwnH20.893999.90.413Contact Map0.707
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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