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FIMA1 - Type-1 fimbrial protein, A chain
UniProt: P04128 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10308
Length: 182 (176)
Sequences: 1481
Seq/Len: 8.41
FIMA1
Paralog alert: 0.95 [within 20: 0.77] - ratio of genomes with paralogs
Cluster includes: ELFA FIMA1 FIMF FIMG FIMI SFMA SFMF YADN YBGD YCBU YCBV YDER YDES YFCP YFCV YGIL YRAH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
124_V 158_A 3.261 1.00
92_A 179_V 2.862 1.00
125_Q 159_R 2.779 1.00
120_T 167_T 2.673 1.00
67_Q 70_A 2.606 1.00
125_Q 161_F 2.539 1.00
78_N 153_T 2.337 1.00
160_Y 171_A 2.251 1.00
127_L 159_R 2.192 1.00
47_D 82_N 2.127 1.00
108_V 123_G 2.111 1.00
45_A 83_D 2.096 1.00
47_D 80_Q 1.969 1.00
47_D 50_S 1.955 1.00
124_V 173_A 1.953 1.00
111_L 171_A 1.929 1.00
128_D 132_A 1.89 1.00
109_L 175_A 1.887 1.00
109_L 136_L 1.865 1.00
66_A 70_A 1.781 1.00
60_V 72_S 1.595 1.00
98_G 109_L 1.57 1.00
57_L 171_A 1.52 1.00
125_Q 133_A 1.51 1.00
2_K 6_L 1.479 1.00
101_I 104_G 1.471 0.99
65_L 162_A 1.451 0.99
41_N 62_T 1.44 0.99
94_V 154_I 1.426 0.99
78_N 155_P 1.407 0.99
50_S 53_Q 1.362 0.99
50_S 80_Q 1.359 0.99
80_Q 153_T 1.313 0.99
58_G 171_A 1.299 0.98
53_Q 79_I 1.295 0.98
76_G 157_Q 1.272 0.98
45_A 82_N 1.249 0.98
58_G 73_S 1.247 0.98
122_V 160_Y 1.242 0.98
147_L 152_N 1.236 0.98
109_L 124_V 1.2 0.97
57_L 124_V 1.19 0.97
4_K 9_V 1.189 0.97
3_I 8_I 1.183 0.97
57_L 160_Y 1.181 0.97
119_A 122_V 1.16 0.96
118_S 170_A 1.152 0.96
131_G 157_Q 1.15 0.96
108_V 161_F 1.141 0.96
6_L 9_V 1.141 0.96
109_L 173_A 1.131 0.95
3_I 6_L 1.131 0.95
5_T 9_V 1.127 0.95
101_I 163_T 1.108 0.95
3_I 9_V 1.107 0.95
65_L 163_T 1.103 0.95
5_T 8_I 1.093 0.94
31_G 177_F 1.091 0.94
7_A 17_S 1.082 0.94
38_E 59_Q 1.08 0.94
68_E 121_N 1.078 0.94
77_F 126_I 1.077 0.94
14_L 17_S 1.073 0.93
53_Q 177_F 1.067 0.93
11_L 16_L 1.06 0.93
64_S 72_S 1.059 0.93
108_V 125_Q 1.056 0.93
71_T 159_R 1.05 0.92
100_A 107_N 1.049 0.92
34_H 174_D 1.044 0.92
39_V 158_A 1.039 0.92
8_I 11_L 1.036 0.92
43_A 152_N 1.035 0.92
60_V 160_Y 1.032 0.92
121_N 164_G 1.029 0.91
27_T 30_G 1.026 0.91
156_F 177_F 1.021 0.91
4_K 7_A 1.018 0.91
71_T 161_F 1.017 0.91
11_L 18_S 1.015 0.91
117_G 170_A 1.013 0.91
7_A 12_S 1.012 0.91
142_S 147_L 1.002 0.90
39_V 60_V 1 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2jtyA10.87361000.237Contact Map0.713
2jmrA10.83521000.242Contact Map0.694
2xg5B10.90661000.269Contact Map0.69
2uy6B20.82421000.27Contact Map0.833
1pdkB10.81321000.286Contact Map0.665
4dwhB20.785799.90.326Contact Map0.758
3bwuF10.763799.90.342Contact Map0.808
2w07B10.769299.90.363Contact Map0.696
3bfqG10.708899.90.376Contact Map0.703
3jwnH20.884699.90.429Contact Map0.733
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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