OPENSEQ.org - FIMF - ECOLI GREMLIN

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FIMF - Protein FimF

UniProt:	P08189	Sequence MRNKPFYLLCAFLWLAVSHALAADSTITIRGYVRDNGCSVAAESTNFTVDLMENAAKQFNNIGATTPVVPFRILLSPCGNAVSAVKVGFTGVADSHNANLLALENTVSAASGLGIQLLNEQQNQIPLNAPSSALSWTTLTPGKPNTLNFYARLMATQVPVTAGHINATATFTLEYQ	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG10313
Length:	176 (159)
Sequences:	1507
Seq/Len:	9.48

FIMF
Paralog alert: 0.95 [within 20: 0.80] - ratio of genomes with paralogs
Cluster includes: ELFA FIMA1 FIMF FIMG FIMI SFMA SFMF YADN YBGD YCBU YCBV YDER YDES YFCP YFCV YGIL YRAH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
115_I	151_A	3.391	1.00
85_V	173_L	3.033	1.00
111_S	161_T	2.973	1.00
116_Q	152_R	2.889	1.00
116_Q	154_M	2.745	1.00
61_N	64_A	2.72	1.00
72_R	146_T	2.68	1.00
153_L	165_I	2.373	1.00
118_L	152_R	2.363	1.00
100_L	114_G	2.355	1.00
39_S	77_P	2.348	1.00
41_A	76_S	2.25	1.00
103_L	165_I	2.119	1.00
41_A	44_S	2.119	1.00
115_I	167_A	2.09	1.00
41_A	74_L	2.057	1.00
112_G	160_V	2.016	1.00
101_L	169_A	1.996	1.00
101_L	127_L	1.99	1.00
119_N	123_N	1.956	1.00
35_D	56_A	1.753	1.00
51_L	165_I	1.723	1.00
60_N	64_A	1.706	1.00
54_N	66_T	1.669	1.00
116_Q	124_Q	1.641	1.00
87_V	147_L	1.562	1.00
139_L	145_N	1.555	1.00
91_G	101_L	1.519	1.00
93_A	99_N	1.496	1.00
74_L	146_T	1.476	1.00
72_R	148_N	1.473	1.00
113_L	153_L	1.448	1.00
51_L	115_I	1.433	1.00
59_F	155_A	1.429	1.00
94_D	156_T	1.391	0.99
100_L	154_M	1.371	0.99
70_P	150_Y	1.346	0.99
59_F	160_V	1.327	0.99
52_M	67_P	1.322	0.99
39_S	76_S	1.309	0.99
44_S	74_L	1.296	0.99
52_M	165_I	1.286	0.99
59_F	156_T	1.279	0.99
47_F	73_I	1.252	0.98
101_L	167_A	1.247	0.98
68_V	152_R	1.219	0.98
44_S	47_F	1.206	0.98
109_A	164_H	1.189	0.98
47_F	171_F	1.187	0.97
61_N	155_A	1.175	0.97
122_Q	150_Y	1.155	0.97
110_A	113_L	1.147	0.97
65_T	154_M	1.144	0.97
32_Y	53_E	1.134	0.96
19_H	23_A	1.129	0.96
101_L	115_I	1.123	0.96
65_T	116_Q	1.121	0.96
62_I	112_G	1.115	0.96
59_F	113_L	1.102	0.96
94_D	114_G	1.099	0.96
65_T	152_R	1.098	0.96
155_A	160_V	1.096	0.95
33_V	151_A	1.093	0.95
90_T	128_N	1.088	0.95
51_L	153_L	1.088	0.95
126_P	129_A	1.087	0.95
92_V	102_A	1.083	0.95
25_S	171_F	1.076	0.95
88_G	174_E	1.066	0.94
108_S	164_H	1.05	0.94
71_F	117_L	1.033	0.93
28_T	168_T	1.031	0.93
25_S	29_I	1.014	0.92
142_G	145_N	1.01	0.92
54_N	153_L	1.007	0.92
18_S	21_L	1.001	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
2jmrA	1	0.8807	100	0.217	Contact Map	0.66
2xg5B	1	0.9318	100	0.255	Contact Map	0.706
2jtyA	1	0.8864	100	0.26	Contact Map	0.707
2uy6B	2	0.8523	100	0.273	Contact Map	0.825
1pdkB	1	0.8466	100	0.291	Contact Map	0.675
3bwuF	1	0.8068	100	0.317	Contact Map	0.818
4dwhB	2	0.7955	99.9	0.347	Contact Map	0.75
2w07B	1	0.8011	99.9	0.363	Contact Map	0.697
3bfqG	1	0.7386	99.9	0.374	Contact Map	0.714
3jwnH	2	0.8807	99.9	0.414	Contact Map	0.752

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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