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YCJN - Putative ABC transporter periplasmic-binding protein YcjN
UniProt: P76042 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13911
Length: 430 (414)
Sequences: 7432
Seq/Len: 17.95
YCJN
Paralog alert: 0.81 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: CYSP MALE MODA POTD POTF SUBI THIB UGPB YCJN YDCS YNJB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
411_D 414_T 4.731 1.00
228_M 413_S 4.335 1.00
30_S 63_K 3.733 1.00
232_T 236_D 3.718 1.00
155_D 281_N 3.617 1.00
57_N 317_K 3.55 1.00
105_I 312_T 3.548 1.00
235_R 239_A 3.524 1.00
47_S 51_A 3.244 1.00
53_F 317_K 3 1.00
413_S 417_Q 2.996 1.00
154_K 283_G 2.977 1.00
223_D 417_Q 2.944 1.00
60_I 314_A 2.802 1.00
30_S 61_T 2.761 1.00
54_E 61_T 2.71 1.00
157_L 262_M 2.655 1.00
172_L 236_D 2.642 1.00
176_Q 240_N 2.58 1.00
152_Y 283_G 2.571 1.00
52_R 321_F 2.549 1.00
417_Q 421_K 2.537 1.00
124_D 128_R 2.537 1.00
106_D 136_S 2.534 1.00
48_K 51_A 2.526 1.00
173_D 177_K 2.522 1.00
311_E 314_A 2.52 1.00
51_A 55_K 2.502 1.00
52_R 55_K 2.453 1.00
410_A 418_A 2.447 1.00
317_K 320_T 2.427 1.00
32_E 63_K 2.368 1.00
167_N 170_Q 2.334 1.00
121_A 345_A 2.333 1.00
324_Q 327_N 2.33 1.00
420_Q 424_D 2.325 1.00
162_L 174_V 2.316 1.00
236_D 240_N 2.3 1.00
34_M 79_L 2.287 1.00
225_P 229_Q 2.272 1.00
155_D 159_K 2.257 1.00
154_K 158_A 2.216 1.00
170_Q 173_D 2.185 1.00
232_T 412_L 2.176 1.00
53_F 60_I 2.159 1.00
28_N 61_T 2.14 1.00
132_T 137_A 2.139 1.00
309_T 312_T 2.131 1.00
50_I 318_F 2.079 1.00
89_I 304_T 2.077 1.00
228_M 412_L 2.026 1.00
50_I 54_E 2.011 1.00
232_T 413_S 1.983 1.00
173_D 176_Q 1.973 1.00
52_R 330_D 1.944 1.00
404_N 410_A 1.944 1.00
71_A 74_T 1.916 1.00
414_T 418_A 1.889 1.00
404_N 409_K 1.883 1.00
87_E 311_E 1.858 1.00
130_V 300_S 1.85 1.00
405_V 415_T 1.805 1.00
424_D 428_E 1.789 1.00
51_A 54_E 1.769 1.00
359_K 363_E 1.766 1.00
88_V 319_V 1.765 1.00
223_D 420_Q 1.761 1.00
313_E 317_K 1.737 1.00
50_I 64_Q 1.732 1.00
215_N 219_K 1.727 1.00
177_K 181_P 1.726 1.00
414_T 417_Q 1.724 1.00
178_L 261_P 1.695 1.00
176_Q 180_D 1.683 1.00
229_Q 232_T 1.682 1.00
179_N 187_G 1.674 1.00
80_S 85_L 1.662 1.00
303_I 319_V 1.644 1.00
60_I 317_K 1.638 1.00
110_V 316_E 1.633 1.00
52_R 56_E 1.612 1.00
108_K 136_S 1.612 1.00
235_R 405_V 1.609 1.00
169_Q 172_L 1.603 1.00
32_E 65_V 1.583 1.00
329_A 333_M 1.579 1.00
247_D 250_E 1.564 1.00
397_V 422_K 1.549 1.00
150_I 285_V 1.547 1.00
421_K 425_E 1.545 1.00
48_K 52_R 1.544 1.00
189_A 260_A 1.543 1.00
318_F 322_M 1.542 1.00
104_L 302_T 1.538 1.00
171_L 188_I 1.537 1.00
401_M 410_A 1.522 1.00
401_M 418_A 1.517 1.00
172_L 176_Q 1.509 1.00
53_F 321_F 1.497 1.00
396_G 400_S 1.484 1.00
54_E 58_P 1.473 1.00
152_Y 285_V 1.462 1.00
206_A 211_A 1.458 1.00
405_V 412_L 1.454 1.00
157_L 162_L 1.45 1.00
154_K 281_N 1.449 1.00
175_A 262_M 1.447 1.00
417_Q 420_Q 1.439 1.00
410_A 415_T 1.431 1.00
418_A 421_K 1.419 1.00
226_E 229_Q 1.417 1.00
18_I 21_C 1.417 1.00
172_L 237_L 1.414 1.00
150_I 262_M 1.408 1.00
156_V 261_P 1.404 0.99
166_K 170_Q 1.394 0.99
228_M 232_T 1.389 0.99
62_V 318_F 1.387 0.99
165_P 170_Q 1.378 0.99
140_G 302_T 1.357 0.99
68_E 71_A 1.349 0.99
140_G 300_S 1.337 0.99
255_F 282_V 1.329 0.99
156_V 178_L 1.315 0.99
156_V 159_K 1.314 0.99
50_I 62_V 1.311 0.99
75_K 79_L 1.306 0.99
236_D 239_A 1.304 0.99
48_K 330_D 1.301 0.99
159_K 185_K 1.289 0.99
105_I 305_A 1.288 0.99
174_V 177_K 1.284 0.99
162_L 177_K 1.283 0.99
401_M 419_S 1.28 0.99
53_F 57_N 1.276 0.99
254_A 259_T 1.271 0.99
321_F 327_N 1.266 0.99
121_A 343_N 1.265 0.99
404_N 418_A 1.259 0.99
128_R 132_T 1.255 0.99
418_A 422_K 1.254 0.99
303_I 316_E 1.254 0.99
54_E 57_N 1.253 0.99
172_L 240_N 1.247 0.99
169_Q 173_D 1.238 0.98
44_A 48_K 1.238 0.98
411_D 415_T 1.228 0.98
53_F 314_A 1.222 0.98
88_V 315_A 1.222 0.98
212_N 216_A 1.221 0.98
29_V 314_A 1.219 0.98
172_L 233_Y 1.211 0.98
52_R 326_D 1.21 0.98
303_I 315_A 1.2 0.98
160_A 178_L 1.199 0.98
305_A 312_T 1.199 0.98
312_T 316_E 1.199 0.98
53_F 318_F 1.196 0.98
17_L 20_G 1.194 0.98
157_L 178_L 1.19 0.98
54_E 59_G 1.188 0.98
233_Y 237_L 1.176 0.98
330_D 336_P 1.171 0.98
314_A 317_K 1.169 0.97
28_N 59_G 1.169 0.97
91_T 302_T 1.167 0.97
316_E 320_T 1.166 0.97
35_H 64_Q 1.164 0.97
105_I 309_T 1.159 0.97
88_V 318_F 1.158 0.97
153_R 280_K 1.158 0.97
325_A 329_A 1.142 0.97
29_V 311_E 1.14 0.97
143_V 301_L 1.139 0.97
422_K 425_E 1.131 0.97
76_V 89_I 1.118 0.96
13_V 16_A 1.117 0.96
410_A 414_T 1.109 0.96
318_F 321_F 1.106 0.96
400_S 422_K 1.099 0.96
209_N 229_Q 1.098 0.96
228_M 416_L 1.098 0.96
254_A 260_A 1.098 0.96
59_G 317_K 1.091 0.96
174_V 262_M 1.09 0.96
401_M 404_N 1.089 0.96
232_T 235_R 1.087 0.96
106_D 109_A 1.084 0.96
87_E 309_T 1.081 0.95
33_F 88_V 1.078 0.95
304_T 308_K 1.075 0.95
99_M 133_E 1.074 0.95
124_D 344_K 1.07 0.95
109_A 316_E 1.069 0.95
231_L 405_V 1.062 0.95
325_A 345_A 1.061 0.95
175_A 187_G 1.056 0.95
327_N 330_D 1.054 0.95
206_A 227_M 1.046 0.94
305_A 308_K 1.046 0.94
220_I 424_D 1.044 0.94
149_G 361_L 1.039 0.94
401_M 415_T 1.038 0.94
118_G 121_A 1.03 0.94
185_K 259_T 1.025 0.93
130_V 137_A 1.021 0.93
162_L 178_L 1.018 0.93
233_Y 236_D 1.011 0.93
229_Q 233_Y 1.008 0.93
48_K 336_P 1.005 0.93
343_N 346_V 1.002 0.92
149_G 284_F 1.002 0.92
43_Q 47_S 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3uorA20.93721000.166Contact Map0.742
3vxbA10.92791000.234Contact Map0.691
2w7yA20.93491000.244Contact Map0.586
4g68A10.93261000.247Contact Map0.776
4c1uA10.91000.252Contact Map0.666
3k01A10.9141000.262Contact Map0.747
4ovjA10.89771000.266Contact Map0.653
1eu8A10.89071000.266Contact Map0.757
2zyoA10.86281000.271Contact Map0.695
2xd3A10.90231000.275Contact Map0.665
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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