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CYSP - Thiosulfate-binding protein
UniProt: P16700 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10195
Length: 338 (312)
Sequences: 1719
Seq/Len: 5.51
CYSP
Paralog alert: 0.63 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: CYSP MALE MODA POTD POTF SUBI THIB UGPB YCJN YDCS YNJB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
52_A 59_K 3.621 1.00
167_G 306_F 3.453 1.00
256_Q 261_E 3.32 1.00
182_Q 186_Q 3.319 1.00
136_D 239_K 3.255 1.00
261_E 265_K 3.25 1.00
278_T 295_K 2.939 1.00
317_E 321_T 2.86 1.00
141_V 187_F 2.843 1.00
265_K 269_N 2.81 1.00
162_Y 322_H 2.755 1.00
274_P 289_N 2.69 1.00
46_P 270_W 2.664 1.00
128_K 234_E 2.428 1.00
248_V 268_L 2.337 1.00
27_E 63_K 2.273 1.00
274_P 278_T 2.271 1.00
278_T 296_L 2.266 1.00
60_L 263_A 2.212 1.00
179_K 182_Q 2.176 1.00
74_L 78_Q 2.083 1.00
45_P 49_Q 2.077 1.00
76_I 85_V 2.067 1.00
138_N 172_A 2.048 1.00
254_N 258_N 1.945 1.00
181_E 331_K 1.914 1.00
26_T 263_A 1.87 1.00
50_Q 55_N 1.859 1.00
255_V 261_E 1.849 1.00
49_Q 54_D 1.836 1.00
26_T 58_D 1.803 1.00
48_E 61_T 1.8 1.00
51_W 58_D 1.789 1.00
43_L 270_W 1.718 1.00
262_K 265_K 1.705 1.00
46_P 279_I 1.689 1.00
273_S 276_A 1.683 1.00
42_A 282_D 1.678 1.00
29_L 63_K 1.671 1.00
294_D 297_K 1.631 0.99
46_P 49_Q 1.625 0.99
274_P 292_V 1.62 0.99
186_Q 190_N 1.612 0.99
248_V 271_L 1.599 0.99
171_K 304_E 1.591 0.99
103_I 249_A 1.584 0.99
183_F 187_F 1.575 0.99
123_G 235_V 1.557 0.99
274_P 291_E 1.55 0.99
250_W 264_A 1.549 0.99
186_Q 189_K 1.518 0.99
97_H 103_I 1.5 0.99
321_T 328_E 1.469 0.99
170_D 311_K 1.461 0.98
27_E 61_T 1.444 0.98
185_T 189_K 1.434 0.98
41_A 45_P 1.431 0.98
173_D 180_T 1.423 0.98
148_I 192_E 1.387 0.98
250_W 261_E 1.386 0.98
176_D 179_K 1.365 0.97
104_P 261_E 1.363 0.97
44_N 267_Y 1.359 0.97
96_L 103_I 1.359 0.97
276_A 280_I 1.358 0.97
42_A 283_Y 1.357 0.97
177_K 321_T 1.356 0.97
178_G 182_Q 1.355 0.97
182_Q 185_T 1.35 0.97
141_V 183_F 1.347 0.97
222_N 237_I 1.332 0.97
28_L 264_A 1.326 0.97
46_P 276_A 1.311 0.96
43_L 273_S 1.307 0.96
141_V 190_N 1.3 0.96
113_N 288_N 1.297 0.96
128_K 232_G 1.292 0.96
266_A 269_N 1.283 0.96
28_L 250_W 1.276 0.96
270_W 273_S 1.272 0.96
43_L 280_I 1.27 0.96
173_D 176_D 1.258 0.95
77_L 99_K 1.255 0.95
309_E 314_S 1.253 0.95
250_W 268_L 1.245 0.95
98_D 316_P 1.242 0.95
126_V 234_E 1.238 0.95
76_I 251_V 1.234 0.95
328_E 331_K 1.229 0.94
37_R 41_A 1.22 0.94
167_G 311_K 1.216 0.94
320_K 324_T 1.213 0.94
278_T 292_V 1.197 0.93
252_D 261_E 1.196 0.93
314_S 317_E 1.181 0.93
130_N 212_D 1.181 0.93
58_D 262_K 1.177 0.93
125_L 221_V 1.177 0.93
277_Q 287_V 1.174 0.92
28_L 263_A 1.17 0.92
138_N 168_A 1.168 0.92
124_F 213_V 1.161 0.92
126_V 236_V 1.156 0.92
51_W 263_A 1.152 0.91
125_L 206_A 1.147 0.91
50_Q 58_D 1.144 0.91
50_Q 258_N 1.143 0.91
306_F 311_K 1.14 0.91
43_L 276_A 1.14 0.91
129_G 232_G 1.133 0.91
146_K 190_N 1.129 0.90
56_G 266_A 1.125 0.90
293_M 297_K 1.115 0.90
328_E 334_A 1.114 0.90
324_T 334_A 1.114 0.90
147_L 192_E 1.114 0.90
148_I 211_G 1.11 0.89
137_W 238_P 1.107 0.89
226_K 299_K 1.102 0.89
168_A 183_F 1.098 0.89
229_E 232_G 1.095 0.88
50_Q 275_Q 1.092 0.88
28_L 62_I 1.087 0.88
278_T 281_T 1.084 0.88
31_S 82_A 1.079 0.87
46_P 275_Q 1.078 0.87
55_N 275_Q 1.077 0.87
315_W 319_M 1.077 0.87
47_F 60_L 1.066 0.87
297_K 302_Q 1.062 0.86
252_D 255_V 1.055 0.86
50_Q 54_D 1.055 0.86
52_A 56_G 1.052 0.86
198_G 217_F 1.044 0.85
170_D 180_T 1.037 0.85
152_P 155_S 1.031 0.84
26_T 60_L 1.025 0.84
278_T 282_D 1.024 0.84
77_L 96_L 1.024 0.84
39_L 279_I 1.02 0.83
56_G 59_K 1.019 0.83
139_D 142_R 1.018 0.83
50_Q 311_K 1.018 0.83
106_D 269_N 1.012 0.83
100_G 252_D 1.011 0.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1sbpA10.89051000.488Contact Map0.648
3rpwA10.91721000.51Contact Map0.6
3c9hA20.90241000.518Contact Map0.701
2qryA40.90531000.529Contact Map0.694
4elqA20.89351000.53Contact Map0.714
1y9uA10.85211000.534Contact Map0.631
2vozA20.89641000.542Contact Map0.606
3pu5A10.86391000.547Contact Map0.674
4edpA20.91121000.548Contact Map0.718
4i1dA40.83141000.556Contact Map0.59
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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