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MALE - Maltose-binding periplasmic protein
UniProt: P0AEX9 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10554
Length: 396 (380)
Sequences: 8017
Seq/Len: 21.10
MALE
Paralog alert: 0.81 [within 20: 0.16] - ratio of genomes with paralogs
Cluster includes: CYSP MALE MODA POTD POTF SUBI THIB UGPB YCJN YDCS YNJB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
382_T 385_E 4.277 1.00
215_K 384_D 4.047 1.00
146_D 267_N 3.795 1.00
103_A 299_K 3.718 1.00
222_V 226_K 3.501 1.00
32_K 62_T 3.457 1.00
219_T 223_D 3.427 1.00
47_A 51_K 3.084 1.00
145_K 269_G 3.076 1.00
104_E 128_K 2.943 1.00
210_D 388_K 2.87 1.00
384_D 388_K 2.83 1.00
53_F 304_E 2.818 1.00
159_P 223_D 2.774 1.00
59_I 301_L 2.75 1.00
143_Y 269_G 2.674 1.00
54_E 60_K 2.634 1.00
298_N 301_L 2.498 1.00
52_K 55_K 2.495 1.00
52_K 308_N 2.494 1.00
163_K 227_N 2.494 1.00
124_R 129_L 2.485 1.00
388_K 392_T 2.482 1.00
48_E 51_K 2.465 1.00
148_L 250_M 2.457 1.00
160_A 164_E 2.435 1.00
32_K 60_K 2.428 1.00
154_T 157_E 2.401 1.00
34_V 62_T 2.393 1.00
117_P 121_D 2.366 1.00
311_L 314_E 2.36 1.00
51_K 55_K 2.352 1.00
114_K 330_L 2.33 1.00
304_E 307_E 2.304 1.00
381_Q 389_D 2.294 1.00
223_D 227_N 2.293 1.00
157_E 160_A 2.252 1.00
212_A 216_A 2.228 1.00
145_K 149_P 2.159 1.00
219_T 383_V 2.138 1.00
50_G 305_F 2.016 1.00
84_D 298_N 2.004 1.00
50_G 54_E 1.984 1.00
86_I 293_N 1.978 1.00
375_N 381_Q 1.961 1.00
53_F 59_I 1.959 1.00
102_L 291_G 1.949 1.00
219_T 384_D 1.911 1.00
385_E 389_D 1.909 1.00
30_E 60_K 1.908 1.00
106_T 128_K 1.898 1.00
344_A 348_E 1.879 1.00
375_N 380_R 1.864 1.00
391_Q 395_T 1.863 1.00
296_S 299_K 1.854 1.00
160_A 163_K 1.848 1.00
300_E 304_E 1.836 1.00
85_I 306_L 1.826 1.00
215_K 383_V 1.822 1.00
376_A 386_A 1.801 1.00
51_K 54_E 1.765 1.00
57_T 304_E 1.746 1.00
123_V 289_S 1.745 1.00
43_Y 47_A 1.727 1.00
216_A 219_T 1.715 1.00
163_K 167_A 1.714 1.00
165_L 249_A 1.707 1.00
50_G 63_V 1.703 1.00
68_K 71_E 1.696 1.00
174_M 248_T 1.692 1.00
52_K 317_E 1.687 1.00
77_A 82_G 1.65 1.00
210_D 391_Q 1.65 1.00
163_K 229_H 1.636 1.00
292_I 306_L 1.627 1.00
141_L 271_T 1.624 1.00
385_E 388_K 1.621 1.00
121_D 124_R 1.615 1.00
36_W 76_V 1.602 1.00
156_E 159_P 1.59 1.00
52_K 56_D 1.582 1.00
159_P 227_N 1.579 1.00
145_K 267_N 1.568 1.00
59_I 304_E 1.566 1.00
222_V 376_A 1.557 1.00
143_Y 271_T 1.555 1.00
34_V 64_E 1.545 1.00
317_E 321_K 1.53 1.00
153_K 157_E 1.526 1.00
159_P 163_K 1.52 1.00
243_F 268_Y 1.501 1.00
54_E 57_T 1.501 1.00
389_D 392_T 1.483 1.00
53_F 308_N 1.476 1.00
147_L 249_A 1.468 1.00
48_E 52_K 1.461 1.00
161_L 164_E 1.46 1.00
372_A 381_Q 1.458 1.00
372_A 389_D 1.456 1.00
305_F 309_Y 1.451 1.00
166_K 172_A 1.447 1.00
108_D 303_K 1.428 1.00
141_L 250_M 1.418 1.00
376_A 383_V 1.41 1.00
103_A 294_A 1.408 1.00
388_K 391_Q 1.4 0.99
367_Y 371_T 1.399 0.99
316_L 320_N 1.384 0.99
235_D 238_I 1.381 0.99
381_Q 386_A 1.375 0.99
196_K 206_D 1.374 0.99
147_L 165_L 1.366 0.99
131_A 289_S 1.365 0.99
54_E 58_G 1.363 0.99
159_P 224_L 1.355 0.99
164_E 168_K 1.353 0.99
368_A 393_R 1.346 0.99
213_G 216_A 1.333 0.99
215_K 219_T 1.326 0.99
158_I 173_L 1.325 0.99
61_V 305_F 1.323 0.99
162_D 250_M 1.322 0.99
159_P 220_F 1.316 0.99
97_A 130_I 1.314 0.99
72_K 76_V 1.304 0.99
389_D 393_R 1.301 0.99
303_K 307_E 1.298 0.99
187_I 192_G 1.296 0.99
103_A 296_S 1.292 0.99
348_E 351_Q 1.275 0.99
292_I 303_K 1.274 0.99
140_S 346_T 1.271 0.99
242_A 247_E 1.25 0.99
53_F 301_L 1.248 0.99
223_D 226_K 1.247 0.99
50_G 61_V 1.239 0.98
131_A 291_G 1.239 0.98
148_L 165_L 1.228 0.98
44_N 48_E 1.228 0.98
382_T 386_A 1.223 0.98
85_I 302_A 1.222 0.98
156_E 160_A 1.219 0.98
152_P 157_E 1.216 0.98
312_T 316_L 1.214 0.98
19_M 22_A 1.202 0.98
242_A 248_T 1.197 0.98
301_L 304_E 1.19 0.98
85_I 305_F 1.182 0.98
104_E 107_P 1.18 0.98
372_A 390_A 1.17 0.97
196_K 203_D 1.167 0.97
371_T 393_R 1.165 0.97
114_K 328_V 1.164 0.97
375_N 389_D 1.158 0.97
293_N 296_S 1.148 0.97
166_K 229_H 1.147 0.97
161_L 250_M 1.143 0.97
220_F 223_D 1.14 0.97
31_G 301_L 1.138 0.97
292_I 302_A 1.135 0.97
308_N 314_E 1.13 0.97
97_A 125_Y 1.124 0.97
219_T 222_V 1.117 0.96
73_F 86_I 1.116 0.96
162_D 229_H 1.116 0.96
294_A 299_K 1.115 0.96
218_L 376_A 1.104 0.96
220_F 224_L 1.099 0.96
260_N 263_T 1.095 0.96
134_I 290_A 1.093 0.96
224_L 229_H 1.092 0.96
31_G 298_N 1.092 0.96
70_E 92_R 1.091 0.96
381_Q 385_E 1.089 0.96
88_W 291_G 1.087 0.96
305_F 308_N 1.087 0.96
144_N 266_V 1.082 0.96
53_F 305_F 1.078 0.95
147_L 170_K 1.073 0.95
299_K 303_K 1.072 0.95
123_V 129_L 1.071 0.95
215_K 387_L 1.069 0.95
77_A 101_L 1.046 0.94
165_L 168_K 1.04 0.94
52_K 313_D 1.039 0.94
84_D 296_S 1.038 0.94
117_P 329_A 1.037 0.94
148_L 161_L 1.034 0.94
107_P 303_K 1.028 0.94
314_E 317_E 1.023 0.93
372_A 375_N 1.018 0.93
44_N 47_A 1.01 0.93
150_N 153_K 1.009 0.93
140_S 270_V 1.004 0.93
190_D 216_A 1.004 0.93
216_A 220_F 1.004 0.93
58_G 304_E 1.004 0.93
345_A 348_E 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3uorA20.97981000.168Contact Map0.756
2zyoA10.94441000.191Contact Map0.704
3iotA30.92931000.205Contact Map0.699
3waiA10.93941000.205Contact Map0.701
3oaiA20.92931000.206Contact Map0.734
3mq9A80.95711000.207Contact Map0.723
3f5fA10.92931000.207Contact Map0.7
4logA20.93431000.208Contact Map0.681
2xd3A10.98231000.209Contact Map0.681
1hsjA20.92931000.209Contact Map0.697
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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