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SUBI - Sulfate-binding protein
UniProt: P0AG78 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10929
Length: 329 (309)
Sequences: 2864
Seq/Len: 9.27
SUBI
Paralog alert: 0.71 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: CYSP MALE MODA POTD POTF SUBI THIB UGPB YCJN YDCS YNJB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
122_K 228_E 3.985 1.00
42_A 264_Y 3.153 1.00
255_K 259_E 3.153 1.00
130_D 233_S 3.01 1.00
176_D 180_A 2.91 1.00
250_E 255_K 2.763 1.00
242_V 262_L 2.751 1.00
161_G 300_F 2.633 1.00
268_P 283_D 2.613 1.00
173_K 176_D 2.59 1.00
142_I 205_G 2.491 1.00
268_P 272_E 2.464 1.00
25_L 58_R 2.46 1.00
41_K 45_A 2.419 1.00
23_Q 58_R 2.41 1.00
311_K 315_E 2.376 1.00
55_V 257_V 2.349 1.00
37_E 41_K 2.285 1.00
44_S 56_V 2.217 1.00
156_Y 316_H 2.142 1.00
98_D 255_K 2.125 1.00
91_I 97_I 2.092 1.00
121_R 124_N 2.067 1.00
72_I 94_R 2.057 1.00
24_L 257_V 2.056 1.00
122_K 226_K 2.05 1.00
40_N 261_Y 2.029 1.00
272_E 289_K 2.021 1.00
267_S 270_G 1.982 1.00
135_I 181_L 1.936 1.00
22_I 257_V 1.914 1.00
69_T 73_N 1.881 1.00
124_N 206_D 1.87 1.00
42_A 273_I 1.849 1.00
42_A 45_A 1.828 1.00
129_H 133_D 1.826 1.00
43_F 55_V 1.824 1.00
50_Q 267_S 1.811 1.00
140_S 206_D 1.804 1.00
259_E 263_K 1.803 1.00
123_G 226_K 1.786 1.00
272_E 276_K 1.771 1.00
92_A 97_I 1.757 1.00
23_Q 56_V 1.743 1.00
254_T 257_V 1.732 1.00
97_I 243_S 1.709 1.00
24_L 261_Y 1.69 1.00
268_P 286_V 1.667 1.00
272_E 290_Y 1.661 1.00
133_D 136_K 1.66 1.00
42_A 270_G 1.609 1.00
24_L 57_I 1.604 1.00
95_G 246_D 1.591 1.00
71_V 80_V 1.586 1.00
256_E 259_E 1.58 1.00
176_D 179_R 1.575 1.00
257_V 260_A 1.553 1.00
248_V 255_K 1.53 1.00
41_K 44_S 1.519 1.00
50_Q 269_E 1.5 1.00
45_A 49_Q 1.465 1.00
33_R 37_E 1.456 1.00
172_A 176_D 1.452 1.00
196_T 208_L 1.448 1.00
38_Q 276_K 1.446 1.00
268_P 285_E 1.445 1.00
256_E 260_A 1.442 1.00
249_V 255_K 1.432 0.99
175_Q 325_Q 1.426 0.99
146_P 149_S 1.425 0.99
248_V 252_K 1.423 0.99
51_T 55_V 1.422 0.99
39_Y 270_G 1.421 0.99
264_Y 270_G 1.41 0.99
80_V 243_S 1.407 0.99
120_V 228_E 1.397 0.99
120_V 230_V 1.376 0.99
46_H 50_Q 1.36 0.99
177_F 181_L 1.359 0.99
248_V 254_T 1.352 0.99
21_D 54_N 1.345 0.99
40_N 44_S 1.342 0.99
244_V 255_K 1.34 0.99
47_W 53_D 1.339 0.99
132_N 166_H 1.31 0.99
79_V 262_L 1.298 0.99
179_R 183_K 1.296 0.99
192_A 195_S 1.295 0.99
260_A 263_K 1.28 0.99
39_Y 264_Y 1.276 0.99
315_E 322_T 1.269 0.98
42_A 269_E 1.263 0.98
128_I 133_D 1.256 0.98
119_L 215_A 1.252 0.98
98_D 246_D 1.246 0.98
114_S 238_A 1.243 0.98
288_K 291_E 1.24 0.98
141_V 207_V 1.24 0.98
272_E 286_V 1.23 0.98
22_I 53_D 1.219 0.98
171_Q 315_E 1.212 0.98
128_I 230_V 1.21 0.98
62_G 66_K 1.209 0.98
26_N 79_V 1.201 0.98
135_I 184_N 1.196 0.98
165_H 298_K 1.192 0.97
22_I 260_A 1.184 0.97
135_I 180_A 1.181 0.97
117_V 229_I 1.176 0.97
44_S 51_T 1.161 0.97
119_L 227_F 1.153 0.97
137_P 184_N 1.149 0.97
303_D 308_G 1.145 0.97
51_T 260_A 1.134 0.96
300_F 305_E 1.126 0.96
78_D 254_T 1.123 0.96
242_V 265_L 1.122 0.96
269_E 272_E 1.115 0.96
100_E 103_K 1.112 0.96
167_N 170_D 1.111 0.96
170_D 173_K 1.107 0.96
270_G 274_A 1.102 0.95
271_Q 281_P 1.101 0.95
244_V 258_A 1.098 0.95
43_F 51_T 1.097 0.95
180_A 183_K 1.088 0.95
131_W 232_P 1.079 0.95
98_D 248_V 1.077 0.95
308_G 311_K 1.074 0.95
322_T 325_Q 1.068 0.94
146_P 153_R 1.068 0.94
112_Y 240_P 1.066 0.94
180_A 184_N 1.064 0.94
249_V 254_T 1.06 0.94
314_K 318_A 1.059 0.94
166_H 170_D 1.056 0.94
27_V 77_A 1.041 0.93
121_R 226_K 1.03 0.93
68_A 72_I 1.025 0.93
291_E 296_K 1.023 0.92
175_Q 179_R 1.013 0.92
24_L 258_A 1.012 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1sbpA10.91791000.452Contact Map0.649
3rpwA10.9241000.462Contact Map0.693
2qryA40.9211000.482Contact Map0.743
3c9hA20.91491000.482Contact Map0.78
4i1dA40.88751000.488Contact Map0.649
4eqbA20.89971000.492Contact Map0.794
4gl0A10.90581000.502Contact Map0.771
4elqA20.90581000.502Contact Map0.779
4euoA10.86631000.503Contact Map0.71
1potA10.88151000.503Contact Map0.731
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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