| UniProt: | P52094 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12125 | ||
| Length: | 228 (214) | ||
| Sequences: | 8024 | ||
| Seq/Len: | 37.50 |
| HISQ
Paralog alert: 0.91 [within 20: 0.54] - ratio of genomes with paralogs Cluster includes: ARTM ARTQ GLNP GLTJ GLTK HISM HISQ METI PHNE SSUC TAUC YECS YEHW |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 26_L | 101_G | 3.536 | 1.00 | |
| 96_G | 168_V | 3.389 | 1.00 | |
| 155_G | 212_L | 3.018 | 1.00 | |
| 189_E | 192_Y | 2.892 | 1.00 | |
| 133_T | 136_Q | 2.873 | 1.00 | |
| 127_A | 137_V | 2.808 | 1.00 | |
| 37_G | 49_F | 2.744 | 1.00 | |
| 180_T | 197_C | 2.681 | 1.00 | |
| 14_L | 18_E | 2.583 | 1.00 | |
| 59_V | 64_L | 2.551 | 1.00 | |
| 34_G | 105_G | 2.445 | 1.00 | |
| 124_I | 137_V | 2.343 | 1.00 | |
| 135_G | 139_R | 2.332 | 1.00 | |
| 123_H | 145_S | 2.292 | 1.00 | |
| 44_L | 48_I | 2.257 | 1.00 | |
| 34_G | 109_T | 2.143 | 1.00 | |
| 35_A | 112_F | 2.106 | 1.00 | |
| 20_A | 162_L | 2.094 | 1.00 | |
| 44_L | 47_L | 2.086 | 1.00 | |
| 115_A | 150_A | 2.052 | 1.00 | |
| 53_T | 109_T | 2.017 | 1.00 | |
| 210_G | 214_F | 1.938 | 1.00 | |
| 38_K | 50_E | 1.896 | 1.00 | |
| 118_A | 149_Y | 1.88 | 1.00 | |
| 202_L | 206_T | 1.834 | 1.00 | |
| 91_D | 94_V | 1.792 | 1.00 | |
| 13_A | 204_F | 1.763 | 1.00 | |
| 10_L | 14_L | 1.746 | 1.00 | |
| 124_I | 128_T | 1.723 | 1.00 | |
| 20_A | 165_T | 1.722 | 1.00 | |
| 178_K | 182_L | 1.721 | 1.00 | |
| 22_S | 97_I | 1.71 | 1.00 | |
| 18_E | 93_M | 1.704 | 1.00 | |
| 15_V | 18_E | 1.698 | 1.00 | |
| 128_T | 137_V | 1.696 | 1.00 | |
| 30_I | 105_G | 1.692 | 1.00 | |
| 214_F | 217_R | 1.677 | 1.00 | |
| 108_F | 154_I | 1.668 | 1.00 | |
| 68_I | 99_T | 1.645 | 1.00 | |
| 184_G | 190_P | 1.614 | 1.00 | |
| 206_T | 210_G | 1.598 | 1.00 | |
| 39_L | 116_F | 1.532 | 1.00 | |
| 24_V | 158_W | 1.511 | 1.00 | |
| 19_L | 168_V | 1.509 | 1.00 | |
| 133_T | 137_V | 1.506 | 1.00 | |
| 59_V | 103_I | 1.491 | 1.00 | |
| 210_G | 213_L | 1.462 | 1.00 | |
| 11_Q | 14_L | 1.46 | 1.00 | |
| 211_V | 214_F | 1.453 | 1.00 | |
| 134_R | 138_F | 1.445 | 1.00 | |
| 39_L | 117_M | 1.437 | 1.00 | |
| 43_R | 47_L | 1.429 | 1.00 | |
| 56_I | 102_F | 1.427 | 1.00 | |
| 64_L | 103_I | 1.421 | 1.00 | |
| 180_T | 193_F | 1.42 | 1.00 | |
| 93_M | 97_I | 1.412 | 1.00 | |
| 26_L | 97_I | 1.395 | 0.99 | |
| 32_L | 112_F | 1.39 | 0.99 | |
| 34_G | 49_F | 1.383 | 0.99 | |
| 110_E | 113_R | 1.372 | 0.99 | |
| 37_G | 40_S | 1.366 | 0.99 | |
| 33_I | 37_G | 1.359 | 0.99 | |
| 211_V | 215_L | 1.35 | 0.99 | |
| 65_M | 99_T | 1.345 | 0.99 | |
| 136_Q | 140_R | 1.342 | 0.99 | |
| 132_F | 136_Q | 1.342 | 0.99 | |
| 42_N | 47_L | 1.315 | 0.99 | |
| 43_R | 46_G | 1.29 | 0.99 | |
| 136_Q | 139_R | 1.266 | 0.99 | |
| 214_F | 218_R | 1.25 | 0.99 | |
| 168_V | 175_D | 1.241 | 0.98 | |
| 184_G | 194_A | 1.22 | 0.98 | |
| 15_V | 173_L | 1.185 | 0.98 | |
| 18_E | 22_S | 1.181 | 0.98 | |
| 112_F | 150_A | 1.18 | 0.98 | |
| 128_T | 134_R | 1.178 | 0.98 | |
| 31_G | 108_F | 1.166 | 0.97 | |
| 37_G | 45_S | 1.163 | 0.97 | |
| 22_S | 101_G | 1.162 | 0.97 | |
| 29_I | 33_I | 1.155 | 0.97 | |
| 108_F | 157_N | 1.146 | 0.97 | |
| 27_A | 104_Y | 1.141 | 0.97 | |
| 48_I | 51_G | 1.137 | 0.97 | |
| 38_K | 110_E | 1.134 | 0.97 | |
| 166_A | 201_Y | 1.119 | 0.96 | |
| 174_E | 178_K | 1.103 | 0.96 | |
| 162_L | 208_S | 1.102 | 0.96 | |
| 218_R | 221_V | 1.1 | 0.96 | |
| 119_V | 149_Y | 1.098 | 0.96 | |
| 47_L | 51_G | 1.096 | 0.96 | |
| 46_G | 50_E | 1.093 | 0.96 | |
| 25_V | 29_I | 1.085 | 0.96 | |
| 160_V | 164_S | 1.081 | 0.95 | |
| 75_A | 78_T | 1.08 | 0.95 | |
| 132_F | 140_R | 1.06 | 0.95 | |
| 113_R | 117_M | 1.054 | 0.95 | |
| 54_T | 206_T | 1.052 | 0.95 | |
| 127_A | 141_I | 1.052 | 0.95 | |
| 124_I | 142_M | 1.048 | 0.94 | |
| 162_L | 204_F | 1.045 | 0.94 | |
| 111_T | 157_N | 1.038 | 0.94 | |
| 94_V | 98_I | 1.025 | 0.93 | |
| 23_S | 101_G | 1.018 | 0.93 | |
| 179_A | 182_L | 1.011 | 0.93 | |
| 207_V | 211_V | 1.01 | 0.93 | |
| 182_L | 186_S | 1.004 | 0.93 | |
| 138_F | 143_F | 1.002 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3tuiA | 4 | 0.9211 | 99.9 | 0.622 | Contact Map | 0.778 |
| 2onkC | 4 | 0.9693 | 99.9 | 0.644 | Contact Map | 0.589 |
| 3rlfF | 1 | 0.9693 | 99.9 | 0.647 | Contact Map | 0.62 |
| 3d31C | 2 | 0.9693 | 99.9 | 0.652 | Contact Map | 0.54 |
| 3rlfG | 1 | 0.9561 | 99.8 | 0.681 | Contact Map | 0.5 |
| 3e7lA | 4 | 0.2763 | 5.7 | 0.963 | Contact Map | 0.594 |
| 2m8gX | 1 | 0.2719 | 3.6 | 0.966 | Contact Map | 0.473 |
| 4l5eA | 1 | 0.2018 | 2.5 | 0.969 | Contact Map | 0.519 |
| 1g2hA | 1 | 0.2675 | 2.5 | 0.969 | Contact Map | 0.384 |
| 1umqA | 1 | 0.3114 | 2.4 | 0.969 | Contact Map | 0.486 |
Sequence Conservation (Image Generated using WebLogo v3)