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OPENSEQ.org

GLTK - Glutamate/aspartate transport system permease protein GltK
UniProt: P0AER5 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12662
Length: 224 (212)
Sequences: 8070
Seq/Len: 38.07

GLTK
Paralog alert: 0.91 [within 20: 0.54] - ratio of genomes with paralogs
Cluster includes: ARTM ARTQ GLNP GLTJ GLTK HISM HISQ METI PHNE SSUC TAUC YECS YEHW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
33_I 105_S 3.519 1.00
100_A 172_V 3.414 1.00
159_L 216_V 3.031 1.00
193_T 196_E 2.88 1.00
137_T 140_Q 2.847 1.00
131_A 141_S 2.778 1.00
44_M 56_A 2.76 1.00
184_A 201_A 2.695 1.00
21_V 25_K 2.582 1.00
41_L 109_A 2.465 1.00
66_I 71_V 2.46 1.00
128_S 141_S 2.351 1.00
139_W 143_K 2.298 1.00
127_Q 149_Q 2.284 1.00
51_P 55_F 2.241 1.00
51_P 54_W 2.163 1.00
41_L 113_S 2.159 1.00
42_A 116_I 2.077 1.00
27_T 166_F 2.065 1.00
119_G 154_M 2.035 1.00
60_V 113_S 2.035 1.00
214_L 218_Y 1.928 1.00
45_R 57_K 1.899 1.00
122_S 153_A 1.858 1.00
17_L 21_V 1.777 1.00
87_L 90_S 1.776 1.00
206_F 210_L 1.764 1.00
128_S 132_L 1.736 1.00
29_T 101_M 1.731 1.00
37_W 109_A 1.728 1.00
22_I 25_K 1.715 1.00
27_T 169_T 1.714 1.00
20_L 208_I 1.702 1.00
182_R 186_T 1.684 1.00
132_L 141_S 1.683 1.00
218_Y 221_R 1.677 1.00
112_Y 158_L 1.648 1.00
75_F 103_A 1.64 1.00
188_G 194_Q 1.623 1.00
210_L 214_L 1.548 1.00
137_T 141_S 1.542 1.00
46_L 120_I 1.529 1.00
26_I 172_V 1.515 1.00
138_H 142_M 1.499 1.00
18_D 21_V 1.498 1.00
31_V 162_G 1.495 1.00
66_I 107_F 1.473 1.00
214_L 217_S 1.459 1.00
215_L 218_Y 1.455 1.00
63_F 106_M 1.419 1.00
46_L 121_Q 1.417 1.00
50_A 54_W 1.415 1.00
184_A 197_M 1.413 1.00
71_V 107_F 1.412 1.00
114_E 117_R 1.404 0.99
33_I 101_M 1.39 0.99
41_L 56_A 1.386 0.99
136_M 140_Q 1.378 0.99
215_L 219_L 1.372 0.99
140_Q 144_L 1.367 0.99
39_T 116_I 1.356 0.99
40_M 44_M 1.35 0.99
25_K 89_L 1.34 0.99
44_M 47_S 1.317 0.99
140_Q 143_K 1.304 0.99
50_A 53_A 1.293 0.99
49_F 54_W 1.292 0.99
72_L 103_A 1.291 0.99
172_V 179_D 1.258 0.99
218_Y 222_R 1.244 0.98
89_L 101_M 1.215 0.98
22_I 177_L 1.211 0.98
38_G 112_Y 1.191 0.98
25_K 29_T 1.189 0.98
34_G 108_E 1.182 0.98
44_M 52_V 1.18 0.98
188_G 198_I 1.18 0.98
132_L 138_H 1.178 0.98
55_F 58_A 1.177 0.98
116_I 154_M 1.175 0.98
112_Y 161_Q 1.165 0.97
45_R 114_E 1.161 0.97
29_T 105_S 1.155 0.97
170_S 205_Y 1.152 0.97
54_W 58_A 1.139 0.97
178_A 182_R 1.134 0.97
32_V 36_L 1.12 0.96
164_V 168_D 1.113 0.96
166_F 212_A 1.106 0.96
36_L 40_M 1.102 0.96
123_I 153_A 1.101 0.96
131_A 145_I 1.087 0.96
117_R 121_Q 1.078 0.95
53_A 57_K 1.07 0.95
136_M 144_L 1.066 0.95
128_S 146_I 1.061 0.95
115_I 161_Q 1.048 0.94
203_F 207_V 1.041 0.94
183_T 186_T 1.041 0.94
166_F 208_I 1.036 0.94
61_N 210_L 1.034 0.94
182_R 185_S 1.022 0.93
18_D 22_I 1.02 0.93
211_S 215_L 1.009 0.93
30_A 105_S 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiA40.924199.90.629Contact Map0.786
3rlfF1199.90.644Contact Map0.616
2onkC40.986699.90.645Contact Map0.575
3d31C20.986699.90.651Contact Map0.53
3rlfG10.959899.80.674Contact Map0.497
2kr6A10.27689.20.958Contact Map0.451
3e7lA40.28127.20.96Contact Map0.599
1ciiA10.26795.90.962Contact Map0.347
1a87A10.28574.90.963Contact Map0.315
1rh1A10.27233.70.965Contact Map0.19

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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