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OPENSEQ.org
SMTA - Protein SmtA
UniProt: P36566 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12167
Length: 261 (254)
Sequences: 1263
Seq/Len: 4.97
SMTA
Paralog alert: 0.12 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: BIOC CMOA SMTA TAM TEHB UBIE UBIG YAFE YJHP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
134_T 137_S 3.527 1.00
136_W 200_W 3.421 1.00
47_R 68_Q 3.215 1.00
53_G 71_L 3.17 1.00
139_L 145_L 3.125 1.00
134_T 138_V 2.632 1.00
116_I 139_L 2.489 1.00
52_G 121_V 2.409 1.00
129_R 197_E 1.974 1.00
135_L 145_L 1.898 1.00
192_Y 196_E 1.814 1.00
49_L 113_V 1.787 1.00
7_D 75_S 1.786 1.00
110_E 137_S 1.762 1.00
70_I 98_I 1.758 1.00
76_A 99_H 1.758 1.00
139_L 200_W 1.756 1.00
48_V 62_M 1.691 0.99
79_I 97_F 1.674 0.99
187_D 190_Q 1.663 0.99
66_G 69_V 1.654 0.99
68_Q 96_Q 1.645 0.99
112_P 137_S 1.639 0.99
53_G 73_D 1.627 0.99
72_C 100_C 1.619 0.99
71_L 82_A 1.617 0.99
193_L 197_E 1.606 0.99
107_S 113_V 1.599 0.99
139_L 143_G 1.587 0.99
79_I 99_H 1.578 0.99
127_D 130_S 1.554 0.99
70_I 113_V 1.551 0.99
145_L 200_W 1.544 0.99
71_L 97_F 1.535 0.99
14_S 85_A 1.514 0.99
76_A 80_D 1.484 0.98
86_A 90_G 1.478 0.98
125_V 131_V 1.459 0.98
77_Q 80_D 1.445 0.98
195_L 252_A 1.444 0.98
120_A 124_W 1.433 0.98
130_S 133_Q 1.418 0.98
129_R 194_W 1.412 0.98
51_A 135_L 1.4 0.97
135_L 139_L 1.376 0.97
86_A 91_V 1.355 0.97
110_E 134_T 1.342 0.96
120_A 123_E 1.32 0.96
42_G 122_L 1.313 0.96
128_P 194_W 1.311 0.96
47_R 83_K 1.3 0.95
193_L 196_E 1.293 0.95
62_M 66_G 1.291 0.95
151_N 207_G 1.288 0.95
114_D 140_R 1.288 0.95
149_F 191_V 1.288 0.95
116_I 145_L 1.282 0.95
203_M 253_R 1.278 0.95
4_R 7_D 1.272 0.95
122_L 191_V 1.264 0.94
14_S 55_E 1.236 0.94
43_P 46_L 1.212 0.93
27_Q 30_L 1.212 0.93
56_G 82_A 1.211 0.93
248_I 252_A 1.21 0.93
152_A 190_Q 1.207 0.92
116_I 135_L 1.204 0.92
78_M 124_W 1.204 0.92
55_E 85_A 1.2 0.92
102_A 134_T 1.196 0.92
101_A 104_D 1.196 0.92
8_D 11_E 1.181 0.91
124_W 150_Y 1.177 0.91
6_F 123_E 1.173 0.91
86_A 97_F 1.171 0.91
13_F 123_E 1.167 0.91
75_S 78_M 1.163 0.90
53_G 59_A 1.162 0.90
129_R 133_Q 1.157 0.90
32_Q 233_T 1.155 0.90
59_A 69_V 1.155 0.90
49_L 138_V 1.154 0.90
135_L 147_L 1.143 0.89
50_D 105_V 1.136 0.89
80_D 83_K 1.131 0.89
60_I 64_E 1.131 0.89
50_D 117_L 1.13 0.89
60_I 85_A 1.122 0.88
120_A 247_Y 1.122 0.88
26_R 30_L 1.117 0.88
62_M 117_L 1.117 0.88
196_E 199_G 1.115 0.88
47_R 111_T 1.115 0.88
50_D 124_W 1.111 0.88
211_F 214_Y 1.09 0.86
46_L 67_H 1.059 0.84
123_E 149_F 1.053 0.84
218_K 221_Q 1.051 0.83
59_A 71_L 1.049 0.83
112_P 134_T 1.041 0.83
119_H 124_W 1.039 0.82
237_R 253_R 1.037 0.82
83_K 87_E 1.034 0.82
224_C 227_A 1.025 0.81
18_Y 22_K 1.019 0.81
230_E 234_R 1.019 0.81
111_T 140_R 1.019 0.81
102_A 121_V 1.017 0.81
6_F 180_L 1.011 0.80
240_P 243_T 1.006 0.80
26_R 123_E 1.004 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4htfA10.99621000.304Contact Map0.641
2avnA20.91571000.432Contact Map0.682
2gs9A20.80841000.483Contact Map0.624
2o57A40.9311000.489Contact Map0.703
1vl5A40.9311000.489Contact Map0.724
2yqzA20.9311000.493Contact Map0.63
3busA20.92721000.493Contact Map0.685
4hgzA60.85821000.497Contact Map0.695
3ccfA20.91951000.499Contact Map0.708
2p7iA20.9081000.5Contact Map0.754
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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