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OPENSEQ.org
YAFE - Uncharacterized protein YafE
UniProt: P30866 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11651
Length: 207 (206)
Sequences: 1909
Seq/Len: 9.27
YAFE
Paralog alert: 0.53 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: BIOC CMOA SMTA TAM TEHB UBIE UBIG YAFE YJHP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
83_E 86_R 3.705 1.00
85_N 140_L 3.683 1.00
19_A 46_T 3.376 1.00
30_L 49_Q 2.794 1.00
27_A 31_D 2.723 1.00
27_A 49_Q 2.591 1.00
83_E 87_I 2.397 1.00
22_A 33_V 2.38 1.00
33_V 47_T 2.241 1.00
57_F 62_F 2.159 1.00
88_L 94_L 2.158 1.00
24_D 30_L 2.146 1.00
4_L 22_A 2.011 1.00
67_S 70_S 2.003 1.00
22_A 47_T 2.001 1.00
23_Y 50_G 1.949 1.00
70_S 74_W 1.947 1.00
10_T 20_V 1.856 1.00
76_D 79_A 1.829 1.00
59_D 86_R 1.808 1.00
63_D 89_K 1.803 1.00
84_V 94_L 1.706 1.00
65_V 84_V 1.672 1.00
30_L 47_T 1.647 1.00
21_V 62_F 1.641 1.00
55_L 87_I 1.637 1.00
31_D 35_Q 1.609 1.00
13_A 66_I 1.604 1.00
11_F 36_A 1.568 1.00
80_A 84_V 1.545 1.00
69_Y 73_H 1.523 1.00
50_G 56_P 1.513 1.00
132_L 136_N 1.509 1.00
28_H 31_D 1.503 1.00
59_D 83_E 1.496 1.00
4_L 24_D 1.496 1.00
52_A 74_W 1.484 1.00
11_F 37_A 1.482 1.00
94_L 135_I 1.478 1.00
74_W 80_A 1.473 1.00
55_L 83_E 1.447 1.00
53_E 74_W 1.446 1.00
68_R 97_M 1.42 0.99
51_Y 54_S 1.415 0.99
24_D 29_M 1.385 0.99
52_A 70_S 1.379 0.99
78_G 82_R 1.377 0.99
88_L 140_L 1.333 0.99
21_V 46_T 1.33 0.99
21_V 48_R 1.318 0.99
181_E 184_T 1.293 0.99
61_A 86_R 1.275 0.99
180_T 183_R 1.266 0.98
25_L 51_Y 1.25 0.98
141_I 204_H 1.243 0.98
22_A 45_I 1.203 0.98
135_I 140_L 1.188 0.97
29_M 73_H 1.177 0.97
135_I 201_V 1.167 0.97
68_R 72_H 1.167 0.97
93_R 204_H 1.166 0.97
56_P 83_E 1.158 0.97
52_A 71_A 1.153 0.97
14_A 44_N 1.152 0.97
68_R 73_H 1.139 0.96
187_A 192_G 1.129 0.96
78_G 137_E 1.129 0.96
133_T 136_N 1.126 0.96
70_S 73_H 1.126 0.96
37_A 47_T 1.116 0.96
88_L 92_G 1.105 0.96
62_F 65_V 1.102 0.95
50_G 55_L 1.096 0.95
169_D 173_I 1.096 0.95
145_L 148_D 1.093 0.95
34_A 38_E 1.092 0.95
135_I 203_A 1.088 0.95
3_G 70_S 1.087 0.95
23_Y 48_R 1.078 0.95
79_A 82_R 1.077 0.95
58_A 61_A 1.074 0.95
156_S 159_A 1.07 0.94
69_Y 198_I 1.067 0.94
21_V 57_F 1.067 0.94
26_S 29_M 1.066 0.94
50_G 67_S 1.062 0.94
85_N 139_N 1.057 0.94
4_L 33_V 1.055 0.94
15_Q 40_R 1.039 0.93
56_P 87_I 1.026 0.93
17_V 20_V 1.025 0.93
73_H 98_D 1.023 0.92
9_P 68_R 1.014 0.92
3_G 72_H 1.012 0.92
31_D 34_A 1.008 0.92
81_L 126_Y 1 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1xxlA211000.253Contact Map0.72
1vl5A411000.27Contact Map0.761
3ccfA20.96621000.366Contact Map0.698
2yqzA20.99031000.376Contact Map0.695
2o57A40.97581000.376Contact Map0.751
2p35A20.96621000.38Contact Map0.633
4kriA30.961499.90.391Contact Map0.68
3mggA2199.90.393Contact Map0.766
3ujcA10.956599.90.399Contact Map0.677
3busA20.975899.90.406Contact Map0.674
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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