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UBIE - Ubiquinone/menaquinone biosynthesis methyltransferase ubiE
UniProt: P0A887 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11473
Length: 251 (233)
Sequences: 4268
Seq/Len: 18.32

UBIE
Paralog alert: 0.62 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: BIOC CMOA SMTA TAM TEHB UBIE UBIG YAFE YJHP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
157_Y 230_F 3.257 1.00
94_A 122_A 3.057 1.00
66_T 90_K 3.053 1.00
150_D 227_D 2.983 1.00
98_E 121_Q 2.963 1.00
217_D 220_T 2.817 1.00
71_A 142_G 2.698 1.00
129_F 134_F 2.677 1.00
30_H 99_S 2.67 1.00
160_L 166_L 2.553 1.00
90_K 118_E 2.537 1.00
155_S 158_R 2.524 1.00
68_L 134_F 2.499 1.00
98_E 102_K 2.45 1.00
72_G 93_L 2.395 1.00
92_V 134_F 2.341 1.00
156_M 166_L 2.329 1.00
160_L 164_G 2.319 1.00
222_K 226_Q 2.299 1.00
150_D 154_R 2.289 1.00
135_D 161_K 2.221 1.00
103_M 106_E 2.127 1.00
102_K 105_R 2.088 1.00
150_D 224_M 2.072 1.00
54_F 236_Y 2.062 1.00
101_L 121_Q 2.033 1.00
160_L 230_F 2.013 1.00
30_H 97_N 1.921 1.00
218_Q 237_N 1.911 1.00
122_A 128_P 1.892 1.00
149_K 224_M 1.842 1.00
72_G 78_T 1.757 1.00
78_T 91_V 1.746 1.00
148_D 151_K 1.746 1.00
223_A 227_D 1.683 1.00
225_M 248_G 1.681 1.00
108_L 119_Y 1.658 1.00
137_I 156_M 1.651 1.00
96_I 123_N 1.649 1.00
104_G 119_Y 1.634 1.00
223_A 226_Q 1.628 1.00
146_V 152_A 1.618 1.00
131_D 158_R 1.603 1.00
130_P 133_T 1.601 1.00
70_L 156_M 1.599 1.00
67_V 81_F 1.58 1.00
83_R 111_I 1.567 1.00
66_T 92_V 1.566 1.00
157_Y 250_K 1.561 1.00
71_A 139_I 1.543 1.00
93_L 119_Y 1.528 1.00
37_D 74_T 1.499 1.00
151_K 154_R 1.497 1.00
59_S 136_C 1.489 1.00
22_A 123_N 1.488 1.00
137_I 160_L 1.465 1.00
155_S 159_V 1.462 1.00
123_N 126_A 1.456 1.00
37_D 107_K 1.451 1.00
94_A 120_V 1.417 1.00
92_V 120_V 1.408 1.00
58_C 236_Y 1.338 0.99
86_G 89_G 1.314 0.99
166_L 225_M 1.308 0.99
101_L 104_G 1.3 0.99
150_D 228_A 1.294 0.99
125_E 148_D 1.293 0.99
57_D 84_L 1.287 0.99
78_T 117_V 1.287 0.99
132_N 250_K 1.279 0.99
97_N 100_M 1.277 0.99
75_G 104_G 1.276 0.99
55_T 167_L 1.271 0.99
62_R 65_Q 1.269 0.99
79_A 108_L 1.266 0.99
105_R 109_R 1.255 0.99
85_V 89_G 1.223 0.98
154_R 227_D 1.219 0.98
92_V 129_F 1.192 0.98
143_L 153_L 1.19 0.98
70_L 124_A 1.162 0.97
66_T 134_F 1.154 0.97
92_V 118_E 1.141 0.97
42_L 198_V 1.139 0.97
75_G 119_Y 1.132 0.97
143_L 221_L 1.111 0.96
79_A 111_I 1.109 0.96
196_S 202_A 1.106 0.96
127_L 159_V 1.099 0.96
41_D 49_R 1.095 0.96
78_T 93_L 1.082 0.96
18_K 148_D 1.08 0.95
20_Q 24_M 1.074 0.95
101_L 119_Y 1.074 0.95
74_T 107_K 1.072 0.95
41_D 48_H 1.068 0.95
239_T 242_V 1.066 0.95
30_H 98_E 1.058 0.95
144_R 170_E 1.058 0.95
106_E 110_N 1.055 0.95
54_F 58_C 1.05 0.94
80_K 84_L 1.049 0.94
128_P 155_S 1.045 0.94
124_A 146_V 1.045 0.94
67_V 91_V 1.044 0.94
20_Q 23_D 1.031 0.94
24_M 27_H 1.025 0.93
69_D 93_L 1.021 0.93
55_T 77_L 1.019 0.93
126_A 151_K 1.013 0.93
113_V 117_V 1.008 0.93
179_L 182_A 1.007 0.93
131_D 155_S 1.002 0.92
185_A 189_H 1 0.92
82_S 116_N 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3dtnA20.88451000.499Contact Map0.738
3bkxA20.87251000.509Contact Map0.556
2o57A40.89641000.511Contact Map0.805
1y8cA10.86061000.515Contact Map0.729
4gekA20.96021000.524Contact Map0.792
3busA20.84861000.526Contact Map0.772
3bxoA20.85261000.528Contact Map0.731
1vl5A40.80881000.53Contact Map0.812
3vc1A120.90441000.53Contact Map0.822
4hgzA60.96411000.534Contact Map0.79

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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