| UniProt: | P12999 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10119 | ||
| Length: | 251 (247) | ||
| Sequences: | 2412 | ||
| Seq/Len: | 9.77 |
| BIOC
Paralog alert: 0.46 [within 20: 0.01] - ratio of genomes with paralogs Cluster includes: BIOC CMOA SMTA TAM TEHB UBIE UBIG YAFE YJHP |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 45_H | 66_Q | 3.357 | 1.00 | |
| 99_L | 104_F | 3.103 | 1.00 | |
| 125_E | 128_R | 3.083 | 1.00 | |
| 130_V | 136_V | 2.773 | 1.00 | |
| 47_L | 104_F | 2.68 | 1.00 | |
| 125_E | 129_V | 2.668 | 1.00 | |
| 51_C | 69_A | 2.616 | 1.00 | |
| 105_D | 131_R | 2.538 | 1.00 | |
| 66_Q | 88_H | 2.514 | 1.00 | |
| 77_L | 91_A | 2.36 | 1.00 | |
| 109_S | 112_A | 2.293 | 1.00 | |
| 74_P | 78_V | 2.287 | 1.00 | |
| 48_D | 69_A | 2.248 | 1.00 | |
| 68_T | 104_F | 2.157 | 1.00 | |
| 193_D | 196_S | 2.089 | 1.00 | |
| 21_E | 53_P | 2.078 | 1.00 | |
| 130_V | 134_G | 2.042 | 1.00 | |
| 126_L | 136_V | 2.016 | 1.00 | |
| 70_L | 92_G | 2.011 | 1.00 | |
| 107_A | 126_L | 2.005 | 1.00 | |
| 45_H | 68_T | 1.926 | 1.00 | |
| 77_L | 89_Y | 1.905 | 1.00 | |
| 69_A | 89_Y | 1.899 | 1.00 | |
| 177_G | 180_Y | 1.849 | 1.00 | |
| 107_A | 130_V | 1.753 | 1.00 | |
| 118_N | 121_T | 1.75 | 1.00 | |
| 50_G | 112_A | 1.74 | 1.00 | |
| 46_V | 106_L | 1.736 | 1.00 | |
| 49_A | 94_I | 1.717 | 1.00 | |
| 49_A | 126_L | 1.701 | 1.00 | |
| 138_F | 246_G | 1.695 | 1.00 | |
| 94_I | 116_C | 1.657 | 1.00 | |
| 29_Q | 33_A | 1.64 | 1.00 | |
| 219_T | 222_Q | 1.623 | 1.00 | |
| 110_N | 139_T | 1.601 | 1.00 | |
| 175_L | 248_I | 1.598 | 1.00 | |
| 95_E | 116_C | 1.574 | 1.00 | |
| 114_Q | 206_A | 1.536 | 1.00 | |
| 101_T | 128_R | 1.519 | 1.00 | |
| 8_A | 12_A | 1.518 | 1.00 | |
| 141_L | 145_S | 1.5 | 1.00 | |
| 34_L | 137_A | 1.467 | 1.00 | |
| 31_A | 56_M | 1.463 | 1.00 | |
| 195_L | 227_Q | 1.46 | 1.00 | |
| 80_A | 89_Y | 1.444 | 1.00 | |
| 225_R | 228_L | 1.431 | 1.00 | |
| 142_V | 244_F | 1.422 | 1.00 | |
| 74_P | 91_A | 1.421 | 1.00 | |
| 6_K | 93_D | 1.418 | 1.00 | |
| 33_A | 185_Q | 1.41 | 0.99 | |
| 101_T | 125_E | 1.387 | 0.99 | |
| 111_L | 141_L | 1.369 | 0.99 | |
| 127_Y | 250_R | 1.354 | 0.99 | |
| 68_T | 90_L | 1.353 | 0.99 | |
| 30_S | 110_N | 1.352 | 0.99 | |
| 220_R | 224_Q | 1.351 | 0.99 | |
| 97_L | 129_V | 1.349 | 0.99 | |
| 27_Q | 115_W | 1.347 | 0.99 | |
| 51_C | 80_A | 1.341 | 0.99 | |
| 23_H | 203_G | 1.337 | 0.99 | |
| 186_P | 242_H | 1.33 | 0.99 | |
| 6_K | 95_E | 1.328 | 0.99 | |
| 97_L | 125_E | 1.323 | 0.99 | |
| 58_R | 83_K | 1.309 | 0.99 | |
| 71_D | 77_L | 1.299 | 0.99 | |
| 71_D | 76_M | 1.293 | 0.99 | |
| 30_S | 111_L | 1.286 | 0.99 | |
| 98_P | 125_E | 1.276 | 0.99 | |
| 14_G | 73_S | 1.261 | 0.99 | |
| 70_L | 90_L | 1.247 | 0.98 | |
| 119_L | 171_I | 1.241 | 0.98 | |
| 47_L | 107_A | 1.241 | 0.98 | |
| 45_H | 131_R | 1.24 | 0.98 | |
| 218_L | 222_Q | 1.237 | 0.98 | |
| 78_V | 82_Q | 1.231 | 0.98 | |
| 57_S | 89_Y | 1.228 | 0.98 | |
| 50_G | 115_W | 1.223 | 0.98 | |
| 95_E | 117_G | 1.221 | 0.98 | |
| 14_G | 75_P | 1.216 | 0.98 | |
| 43_Y | 65_A | 1.211 | 0.98 | |
| 172_E | 176_N | 1.205 | 0.98 | |
| 95_E | 112_A | 1.202 | 0.98 | |
| 192_D | 196_S | 1.193 | 0.98 | |
| 48_D | 54_G | 1.171 | 0.97 | |
| 30_S | 243_L | 1.171 | 0.97 | |
| 92_G | 98_P | 1.168 | 0.97 | |
| 148_E | 240_T | 1.168 | 0.97 | |
| 33_A | 37_M | 1.158 | 0.97 | |
| 57_S | 69_A | 1.147 | 0.97 | |
| 127_Y | 178_V | 1.147 | 0.97 | |
| 14_G | 17_A | 1.146 | 0.97 | |
| 101_T | 129_V | 1.141 | 0.97 | |
| 104_F | 107_A | 1.14 | 0.97 | |
| 37_M | 183_H | 1.139 | 0.97 | |
| 100_A | 103_T | 1.139 | 0.97 | |
| 79_Q | 82_Q | 1.137 | 0.97 | |
| 228_L | 232_Q | 1.134 | 0.97 | |
| 33_A | 245_L | 1.121 | 0.96 | |
| 116_C | 122_A | 1.113 | 0.96 | |
| 71_D | 93_D | 1.11 | 0.96 | |
| 20_Y | 27_Q | 1.11 | 0.96 | |
| 202_K | 205_G | 1.101 | 0.96 | |
| 107_A | 129_V | 1.1 | 0.96 | |
| 167_P | 170_E | 1.096 | 0.96 | |
| 191_F | 200_S | 1.09 | 0.96 | |
| 137_A | 247_V | 1.088 | 0.95 | |
| 179_H | 249_A | 1.077 | 0.95 | |
| 48_D | 52_G | 1.075 | 0.95 | |
| 24_A | 27_Q | 1.061 | 0.95 | |
| 139_T | 243_L | 1.055 | 0.94 | |
| 94_I | 112_A | 1.049 | 0.94 | |
| 48_D | 67_V | 1.045 | 0.94 | |
| 50_G | 109_S | 1.035 | 0.94 | |
| 48_D | 70_L | 1.026 | 0.93 | |
| 111_L | 114_Q | 1.022 | 0.93 | |
| 221_S | 225_R | 1.02 | 0.93 | |
| 13_F | 20_Y | 1.019 | 0.93 | |
| 185_Q | 245_L | 1.018 | 0.93 | |
| 51_C | 71_D | 1.016 | 0.93 | |
| 44_T | 65_A | 1.004 | 0.92 | |
| 200_S | 204_I | 1.004 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2p35A | 2 | 0.9402 | 100 | 0.384 | Contact Map | 0.654 |
| 3ccfA | 2 | 0.9721 | 100 | 0.402 | Contact Map | 0.732 |
| 2yqzA | 2 | 0.9442 | 100 | 0.421 | Contact Map | 0.719 |
| 4hg2A | 2 | 0.9522 | 100 | 0.441 | Contact Map | 0.634 |
| 4fsdA | 1 | 0.9641 | 100 | 0.444 | Contact Map | 0.65 |
| 1vl5A | 4 | 0.9402 | 100 | 0.448 | Contact Map | 0.797 |
| 3busA | 2 | 0.9641 | 100 | 0.459 | Contact Map | 0.728 |
| 3egeA | 1 | 0.9243 | 100 | 0.46 | Contact Map | 0.689 |
| 1xxlA | 2 | 0.9004 | 100 | 0.469 | Contact Map | 0.744 |
| 2o57A | 4 | 0.9482 | 100 | 0.471 | Contact Map | 0.772 |
Sequence Conservation (Image Generated using WebLogo v3)