May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YGIS - Putative binding protein YgiS
UniProt: Q46863 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13021
Length: 535 (503)
Sequences: 9342
Seq/Len: 18.57
YGIS
Paralog alert: 0.87 [within 20: 0.29] - ratio of genomes with paralogs
Cluster includes: DDPA DPPA GSIB MPPA NIKA OPPA SAPA SGRR YBAE YEJA YGIS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
215_D 226_R 4.617 1.00
307_R 368_Q 4.01 1.00
319_Q 323_Q 3.952 1.00
161_D 164_T 3.873 1.00
160_T 166_E 3.826 1.00
158_K 166_E 3.776 1.00
361_M 364_A 3.735 1.00
99_S 163_R 3.508 1.00
466_A 470_Q 3.36 1.00
213_V 226_R 3.358 1.00
474_I 479_K 3.339 1.00
459_W 494_Q 3.149 1.00
115_V 119_Q 3.14 1.00
115_V 159_A 3.086 1.00
83_R 96_H 3.009 1.00
378_R 407_Q 2.982 1.00
364_A 368_Q 2.932 1.00
317_D 320_L 2.895 1.00
463_Q 466_A 2.867 1.00
312_L 400_W 2.866 1.00
112_E 159_A 2.857 1.00
301_P 304_N 2.817 1.00
85_E 96_H 2.803 1.00
314_L 361_M 2.784 1.00
71_D 75_Q 2.637 1.00
306_V 310_R 2.616 1.00
378_R 409_T 2.569 1.00
479_K 482_A 2.565 1.00
307_R 365_L 2.541 1.00
68_V 84_W 2.53 1.00
307_R 310_R 2.521 1.00
461_N 490_I 2.499 1.00
461_N 494_Q 2.49 1.00
109_L 209_N 2.463 1.00
190_H 194_A 2.444 1.00
87_L 91_K 2.442 1.00
92_R 166_E 2.41 1.00
158_K 168_T 2.384 1.00
401_K 407_Q 2.335 1.00
94_I 166_E 2.311 1.00
92_R 168_T 2.308 1.00
96_H 164_T 2.307 1.00
71_D 77_Q 2.297 1.00
476_D 479_K 2.293 1.00
82_E 99_S 2.292 1.00
118_W 167_V 2.29 1.00
101_L 109_L 2.286 1.00
463_Q 486_Q 2.286 1.00
213_V 229_P 2.285 1.00
102_Q 108_P 2.222 1.00
104_S 228_N 2.214 1.00
114_F 165_L 2.208 1.00
470_Q 483_L 2.199 1.00
102_Q 230_K 2.181 1.00
380_E 409_T 2.172 1.00
224_T 241_Q 2.15 1.00
86_I 93_Y 2.143 1.00
482_A 486_Q 2.131 1.00
450_S 465_D 2.13 1.00
380_E 411_R 2.101 1.00
450_S 460_K 2.087 1.00
296_F 498_I 2.082 1.00
212_F 239_L 2.075 1.00
310_R 361_M 2.042 1.00
107_Q 191_H 2.01 1.00
300_K 428_M 2.008 1.00
112_E 190_H 2.003 1.00
47_D 120_R 1.972 1.00
110_T 113_D 1.971 1.00
65_E 79_A 1.944 1.00
464_Y 487_A 1.938 1.00
100_G 108_P 1.937 1.00
489_V 493_Q 1.916 1.00
467_L 486_Q 1.884 1.00
296_F 429_L 1.884 1.00
112_E 115_V 1.854 1.00
256_R 261_E 1.852 1.00
312_L 406_A 1.849 1.00
34_V 241_Q 1.831 1.00
112_E 162_D 1.83 1.00
216_Q 224_T 1.824 1.00
218_V 221_E 1.822 1.00
471_A 484_Y 1.81 1.00
82_E 96_H 1.8 1.00
113_D 190_H 1.788 1.00
34_V 243_E 1.785 1.00
486_Q 489_V 1.763 1.00
226_R 241_Q 1.752 1.00
332_A 502_Y 1.75 1.00
483_L 486_Q 1.742 1.00
84_W 95_F 1.741 1.00
471_A 483_L 1.74 1.00
313_Y 495_A 1.728 1.00
105_D 189_P 1.714 1.00
397_S 401_K 1.711 1.00
227_K 240_Q 1.706 1.00
216_Q 222_K 1.693 1.00
38_N 262_V 1.692 1.00
306_V 494_Q 1.69 1.00
462_A 466_A 1.672 1.00
68_V 95_F 1.67 1.00
316_V 396_L 1.669 1.00
258_R 274_A 1.661 1.00
303_F 312_L 1.652 1.00
363_K 367_K 1.651 1.00
53_E 56_A 1.649 1.00
303_F 379_F 1.645 1.00
215_D 241_Q 1.629 1.00
111_A 159_A 1.619 1.00
470_Q 479_K 1.614 1.00
463_Q 490_I 1.595 1.00
218_V 222_K 1.59 1.00
360_A 363_K 1.579 1.00
101_L 209_N 1.578 1.00
467_L 483_L 1.577 1.00
107_Q 189_P 1.569 1.00
315_T 404_L 1.557 1.00
110_T 162_D 1.547 1.00
308_V 369_A 1.541 1.00
82_E 98_R 1.537 1.00
482_A 485_Q 1.536 1.00
94_I 164_T 1.531 1.00
479_K 483_L 1.531 1.00
308_V 366_L 1.528 1.00
247_L 256_R 1.525 1.00
104_S 213_V 1.524 1.00
421_A 426_D 1.521 1.00
87_L 92_R 1.512 1.00
167_V 176_F 1.51 1.00
420_D 424_A 1.509 1.00
87_L 94_I 1.509 1.00
36_R 243_E 1.509 1.00
367_K 372_D 1.505 1.00
299_E 458_H 1.496 1.00
365_L 368_Q 1.49 1.00
222_K 243_E 1.473 1.00
460_K 465_D 1.473 1.00
280_P 511_P 1.471 1.00
273_P 276_E 1.47 1.00
160_T 164_T 1.457 1.00
319_Q 331_P 1.442 1.00
108_P 163_R 1.433 1.00
481_N 485_Q 1.427 1.00
414_E 417_T 1.418 1.00
310_R 495_A 1.417 1.00
322_A 331_P 1.416 1.00
65_E 209_N 1.415 1.00
96_H 163_R 1.412 1.00
98_R 101_L 1.408 1.00
306_V 493_Q 1.399 0.99
440_D 480_R 1.39 0.99
33_Q 240_Q 1.378 0.99
364_A 367_K 1.377 0.99
189_P 192_V 1.375 0.99
224_T 243_E 1.362 0.99
490_I 494_Q 1.361 0.99
474_I 483_L 1.348 0.99
93_Y 176_F 1.345 0.99
256_R 262_V 1.326 0.99
376_P 407_Q 1.326 0.99
390_E 394_I 1.325 0.99
111_A 160_T 1.324 0.99
159_A 162_D 1.321 0.99
263_D 510_K 1.317 0.99
65_E 232_R 1.317 0.99
156_G 168_T 1.315 0.99
358_R 361_M 1.313 0.99
467_L 490_I 1.312 0.99
282_E 511_P 1.296 0.99
225_A 244_Y 1.29 0.99
102_Q 228_N 1.286 0.99
227_K 237_T 1.273 0.99
226_R 229_P 1.265 0.99
115_V 157_V 1.26 0.99
399_E 402_K 1.245 0.98
96_H 99_S 1.239 0.98
459_W 464_Y 1.232 0.98
252_T 256_R 1.231 0.98
425_G 458_H 1.23 0.98
104_S 230_K 1.227 0.98
233_D 236_H 1.22 0.98
114_F 187_P 1.22 0.98
411_R 421_A 1.218 0.98
263_D 512_Y 1.218 0.98
104_S 214_L 1.212 0.98
310_R 365_L 1.212 0.98
359_V 404_L 1.206 0.98
300_K 304_N 1.201 0.98
78_P 84_W 1.185 0.98
360_A 364_A 1.183 0.98
463_Q 467_L 1.168 0.97
80_Q 209_N 1.165 0.97
42_D 217_W 1.16 0.97
359_V 363_K 1.159 0.97
470_Q 474_I 1.156 0.97
82_E 163_R 1.152 0.97
215_D 224_T 1.151 0.97
87_L 90_G 1.151 0.97
381_L 408_V 1.151 0.97
466_A 469_N 1.151 0.97
105_D 191_H 1.145 0.97
96_H 161_D 1.142 0.97
395_A 399_E 1.14 0.97
338_P 502_Y 1.135 0.97
467_L 470_Q 1.133 0.97
296_F 312_L 1.129 0.97
397_S 410_L 1.129 0.97
470_Q 486_Q 1.127 0.97
38_N 253_G 1.121 0.97
95_F 167_V 1.109 0.96
171_Q 473_Q 1.106 0.96
36_R 245_L 1.103 0.96
157_V 165_L 1.102 0.96
383_Y 410_L 1.099 0.96
94_I 160_T 1.098 0.96
379_F 408_V 1.094 0.96
108_P 162_D 1.092 0.96
227_K 236_H 1.091 0.96
321_I 392_T 1.088 0.96
400_W 408_V 1.087 0.96
85_E 94_I 1.085 0.96
320_L 399_E 1.084 0.96
69_W 77_Q 1.082 0.96
69_W 79_A 1.081 0.95
415_W 419_L 1.08 0.95
396_L 400_W 1.08 0.95
191_H 195_K 1.079 0.95
257_Y 508_L 1.071 0.95
306_V 495_A 1.069 0.95
155_L 170_E 1.063 0.95
379_F 429_L 1.061 0.95
315_T 400_W 1.06 0.95
140_N 168_T 1.057 0.95
98_R 232_R 1.057 0.95
478_T 481_N 1.056 0.95
281_G 508_L 1.055 0.95
398_S 402_K 1.048 0.94
35_F 513_V 1.048 0.94
459_W 496_P 1.046 0.94
66_G 79_A 1.045 0.94
119_Q 159_A 1.039 0.94
322_A 329_R 1.037 0.94
326_L 329_R 1.035 0.94
115_V 165_L 1.033 0.94
258_R 278_S 1.031 0.94
282_E 509_L 1.026 0.94
285_I 504_P 1.026 0.94
313_Y 318_R 1.023 0.93
295_N 430_S 1.014 0.93
113_D 116_L 1.011 0.93
159_A 166_E 1.01 0.93
213_V 228_N 1.009 0.93
514_G 533_K 1.009 0.93
35_F 239_L 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4fajA10.97571000.093Contact Map0.731
3o9pA10.96071000.104Contact Map0.74
3zs6A10.94021000.11Contact Map0.763
1jetA10.95891000.113Contact Map0.803
4gl8A20.9721000.125Contact Map0.803
1uqwA20.92521000.156Contact Map0.784
1xocA10.9141000.159Contact Map0.757
3m8uA10.91211000.16Contact Map0.79
1dpeA10.90471000.164Contact Map0.794
3drfA10.93461000.166Contact Map0.694
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.2381 seconds.